Urokinase plasminogen activator impairs SNP and PGE2 cerebrovasodilation after brain injury through activation of LRP and ERK MAPK

Journal of Neurotrauma

Volumn 25, Issue 11, 2008, Pages 1375-1381

  Armstead, William M ^a   Christine, Amy J ^a   Higazi, Abd Al Roof ^a,b   Cines, Douglas B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cerebral circulation; Newborn; Plasminogen activators; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; IMMUNOGLOBULIN G; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NITROPRUSSIDE SODIUM; PAPAVERINE; PROSTAGLANDIN E2; UROKINASE; UROKINASE RECEPTOR;

ANIMAL EXPERIMENT; ARTERY DILATATION; ARTICLE; BLOOD CHEMISTRY; BRAIN INJURY; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; MALE; NONHUMAN; PIA ARTERY; PIGLET; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; CEREBRAL ARTERIES; CEREBROVASCULAR CIRCULATION; DINOPROSTONE; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; LIPOPROTEIN LIPASE; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE DONORS; NITROPRUSSIDE; PAPAVERINE; PLASMINOGEN ACTIVATORS; SWINE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASODILATION; VASODILATOR AGENTS;

EID: 57349131018     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2008.0666     Document Type: Article

References (28)

1. Adelson, P.D., Clyde, B., Kochanek, P.M., Wisniewski, S.R., Marion, D.W., and Yonas, H. (1997). Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report. Pediatr. Neurosurg. 26, 200-207.
2. Akkawi, S., Nassar, T., Tarshis, M., Cines, D.B., and Higazi, A.A.R. (2006). LRP and avB3 mediate tPA-activation of smooth muscle cells. Am. J. Physiol. Heart Circ. 291, H1351-H1359.
3. Armstead, W.M. (2003). PTK, ERK, and p38 MAPK contribute to impaired NMDA vasodilation after brain injury. Eur. J. Pharmacol. 474, 249-254.
4. Armstead, W.M. (1998). Brain injury impairs prostaglandin cerebrovasodilation. J. Neurotrauma 15, 721-729.
5. + channel function in piglet cerebral arteries. Stroke 28, 2273-2280.
6. + channels in cGMP-mediated pial artery vaso-dilation. Am. J. Physiol. 270, H423-H426.
7. Armstead, W.M., Cines, D., Bdeir, K., Stein, S., and Higazi, A. (2006). uPA contributes to initial age-dependent cerebrovascular hyperemia after brain injury through LRP and ERK MAPK. J. Neurosurg. Anesthesio.l 18, 290-291.
8. Armstead, W.M., Cines, D.B., and Higazi, A.A.R. (2005). Plasminogen activators contribute to age-dependent impairment of NMDA cerebrovasodilation after brain injury. Dev. Brain Res. 156, 139-146.
9. Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and - independent mechanisms. Science 286, 1358-1362.
10. Bruce, D.A., Alavi, A., Bilaniuk, L., Dolinskas, C., Obrist, W., and Uzzell, B. (1981). Diffuse cerebral swelling following head injuries in children; the syndrome of malignant brain edema. Neurosurgery 54, 170-178.
11. Bu, G., Williams, S., Strickland, D.R., and Schwartz, A.L. (1992). Low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc. Natl. Acad. Sci. USA 89, 7427-7431.
12. Collen, D., and Lijnen, H.R. (1991). Basic and clinical aspects of fibrinolysis and thrombolysis. Blood 78, 3114-3124.
13. Faraci, F.M., and Heistad, D.B. (1998). Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol. Rev. 78, 53-97.
14. Gennarelli, T.A. (1994). Animate models of human head injury. J. Neurotrauma 11, 357-368.
15. Hicks, R.R., Martin, V.B., Zhang, L., and Seroogy, K.B. (1999). Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp. Neurol. 160, 469-478.
16. Higazi, A.A., Bdeir, K., Hiss, E., Arad, S., Kuo, A., Barghouti, C., and Cines, D.B. (1998). Lysis of plasma clots by urokinase-soluble urokinase receptor complexes. Blood 92, 2075-2083.
17. Higazi, A.A., Mazar, A., Wang, J., Reilly, R., Henkin, J., Kniss, D., and Cines, D. (1996a). Single chain urokinase-type plasminogen activator bound to its receptor is relatively resistant to plasminogen activator inhibitor type 1. Blood 87, 3545-3549.
18. Higazi, A.A., Upson, R.H., Cohen, R.L., Manuppello, J., Bognacki, J., Henkin, J., McCrae, K.R., Kounnas, M.Z., Strickland, D.K., Preissner, K.T., Lawler, J., and Cines, D.B. (1996b). Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins. Blood 88, 542-551.
19. Hymel, K.P., Abshire, T.C., Luckey, D.W., and Jenny, C. (1997). Coagulopathy in pediatric abusive head trauma. Pediatrics 99, 371-375.
20. Laher, I., and Zhang, J.H. (2001). Protein kinase C and cerebral vasospasm. J. Cereb. Blood Flow Metab. 21, 887-906.
21. Leffler, C.W., Armstead, W.M., and Shibata, M. (1993). Role of the eicosanoids in cerebral hemodynamics, in: The Regulation of Cerebral Blood Flow. J.W. Phyllis (ed), CRC Press: Boca Raton, FL, pps. 297-313.
22. Nassar, T., Akkawi, S., Shin, A., Haj-Yehia, A., Bdeir, K., Tarshis, M., Heyman, S.N., and Higazi, A.A. (2004). In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone. Blood 103, 897-202.
23. Otani, N., Nawashiro, H., Fukui, S., Nomura, N., and Shima, K., (2002). Temporal and spatial profile of phosphorylated mitogen-activated protein kinase pathways after lateral fluid percussion injury in the cortex of the rat brain. J. Neurotrauma 19, 1587-1596.
24. Richards, H.K., Simac, S., Piechnik, S., and Pickard, J.D. (2001). Uncoupling of cerebral blood flow and metabolism after cerebral contusion in the rat. J. Cereb. Blood Flow Metab. 21, 779-781.
25. Rodriguez, J.G. (1990). Childhood injuries in the United States. A priority issue. Am. J. Dis. Child. 144, 625-626.
26. Wei, E.P., Dietrich, W.D., Povlishock, J.T., Navari, R.M., and Kontos, H.A. (1980). Functional, morphological, and metabolic abnormalities of the cerebral microcirculation after concussive brain injury in cats. Circ. Res. 46, 37-47.
27. Willis, A.P., and Leffler, C.W. (1999). NO and prostanoids: age dependence of hypercapnia and histamine-induced dilations of pig pial arterioles. Am. J. Physiol. 277, H299-H307.
28. Zuckerman, S.L., Armstead, W.M., Hsu, P., Shibata, M., and Leffler, C.W. (1996). Age dependence of cerebrovascular response mechanisms in domestic pigs. Am. J. Physiol. 271, H535-H540.