Age dependence of cerebrovascular response mechanisms in domestic pigs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 2 40-2, 1996, Pages

  Zuckerman, S L ^a   Armstead, W M ^b   Hsu, P ^b   Shibata, M ^b   Leffler, C W ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b NONE

Author keywords

acetylcholine; cerebral circulation; hypercapnia; indomethacin; nitric oxide; nitric oxide synthase inhibition; prostanoids

Indexed keywords

ACETYLCHOLINE; INDOMETACIN; NITRIC OXIDE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; ATTENUATION; BRAIN BLOOD FLOW; BRAIN CIRCULATION; CONTROLLED STUDY; FEMALE; HYPERCAPNIA; NEWBORN; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; SWINE; VASODILATATION;

EID: 33750688895     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.2.h535     Document Type: Article

References (31)

1. Armstead, W. M., R. Mirro, D. W. Busija, and C. W. Leffler. Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction. J. Pharmacol. Exp. Ther. 251: 1012-1019, 1989.
2. Armstead, W. M., R. Mirro, C. W. Leffler, and D. W. Busija. Acetylcholine produces cerebrovascular constriction through activation of muscarinic-1 receptors in the newborn pig. J. Pharmacol. Exp. Ther. 247: 926-933, 1988.
3. Armstead, W. M., S. L. Zuckerman, M. Shibata, H. Parfenova, and C. W. Leffler. Different pial arteriolar responses to acetylcholine in the newborn and juvenile pig. J. Cereb. Blood Flow Metab. 14: 1008-1095, 1994.
4. Faraci, F. M. Role of nitric oxide in regulation of basilar artery tone in vivo. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1216-H1221, 1990.
5. Faraci, F. M., K. R. Breese, and D. D. Heistad. Cerebral vasodilation during hypercapnia: role of glibencamide-sensitive potassium channels and nitric oxide. Stroke 25: 1679-1683, 1994.
6. Faraci, F. M., K. R. Breese, and D. D. Heistad. Nitric oxide contributes to dilatation of cerebral arterioles during seizures. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H2209-H2212, 1993.
7. 2 in newborn pig brain microvascular endothelial cells. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1485-H1492, 1993.
8. Iadecola, C., and X. Xiaohong. Nitro-L-arginine attenuates hypercapnic cerebrovasodilation without affecting cerebral metabolism. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol 35): R518-R525, 1994.
9. Iadecola, C., and F. Zhang. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R546-R552, 1994.
10. Iadecola, C., F. Zhang, and X. Xu. SEN-1 reverses attenuation of hypercapnic cerebrovasodilation by nitric oxide synthase inhibitors. Am. J. Physiol. 267 (Regulatory Integrative Comp. Physiol. 36): R228-R235, 1994.
11. 2 inhalation in Sprague-Dawley rats. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H837-H843, 1994.
12. Leffler, C. W., and D. W. Busija. Arachidonic acid metabolites and perinatal cerebral hemodynamics. Sem. Perinatol. 11: 31-42, 1987.
13. Leffler, C. W., D. W. Busija, A. M. Fletcher, J. R. Beasley, J. R. Hessler, and R. S. Green. Effects of indomethacin upon cerebral hemodynamics of newborn pigs. Pediat. Res. 19: 1160-1164, 1985.
14. Leffler, C. W., R. Mirro, L. J. Pharris, and M. Shibata. Permissive role of prostacyclin in cerebral vasodilation to hypercapnia in newborn pigs. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H285-H291, 1994.
15. Leffler, C. W., R. Mirro, D. R. Shanklin, W. M. Armstead, and M. Shibata. Light/dye microvascular injury selectively eliminates hypercapnia-induced pial arteriolar dilation in newborn pigs. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H623-H630, 1994.
16. Liu, S. F., A. A. Hislop, S. G. Haworth, and P. J. Barnes. Developmental changes in endothelium-dependent pulmonary vasodilation in pigs. Br. J. Pharmacol. 106: 324-330, 1992.
17. Pearce, W. J., A. D. Hull, D. M. Long, and L. D. Longo. Developmental changes in ovine cerebral artery composition and reactivity. Am. J. Physiol. 261 (Regulatory Integrative Comp. Physiol. 30): R458-R465, 1991.
18. Pearce, W. J., A. D. Hull, D. M. Long, and C. R. White. Effects of maturation on cyclic GMP-dependent vasodilation in ovine basilar and carotid arteries. Pediat. Res. 36: 25-33, 1994.
19. Pelligrino, D. A., H. M. Koenig, and R. F. Albrecht. Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat. J. Cereb. Blood Flow Metab. 13: 80-87, 1993.
20. Phillis, J. W., and R. E. DeLong. An involvement of adenosine in cerebral blood flow regulation during hypercapnia. Gen. Pharmacol. 18: 133-139, 1987.
21. Rosenblum, W. I., H. Nishimura, and G. H. Nelson. Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1396-H1401, 1990.
22. 2 responsiveness. J. Cereb. Blood Flow Metab. 14: 49-58, 1994.
23. Simpson, R. E., and J. W. Phillis. Adenosine deaminase reduces hypoxic and hypercapnic dilation of rat pial arterioles: evidence for mediation by adenosine. Brain Res. 553: 305-308, 1991.
24. Wagerle, L. C., and D. W. Busija. Cholinergic mechanisms in the cerebral circulation of the newborn piglet: effect of inhibitors of arachidonic acid metabolism. Circ. Res. 64: 1030-1036, 1989.
25. 2 reactivity of cerebral arterioles is restored by vasodilator prostaglandin. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1332-H1338, 1994.
26. Wagerle, L. C., C. D. Kurth, and R. A. Roth. Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H1432-H1438, 1990.
27. 2 responses in cerebral arteries of the newborn pig: role of phospholipase, cyclooxygenase, and lipoxygenase pathways. Circ. Res. 62: 1019-1026, 1988.
28. Wang, Q., D. A. Pelligrino, V. L. Baughman, H. M. Koenig, and R. F. Albrecht. The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J. Cereb. Blood Flow Metab. 15: 774-778, 1995.
29. 2 in vivo. J. Cereb. Blood Flow Metab. 14: 944-951, 1994.
30. G-nitro-L-arginine and indomethacin on the hypercapnic cerebral blood flow increase in rats. Brain Res. 641: 257-264, 1994.
31. Zellers, T. M., and P. M. Vanhoutte. Endothelium-dependent relaxations of piglet pulmonary arteries augment with maturation. Pediat. Res. 30: 176-180, 1991.