Severe obesity confounds the interpretation of low-dose dexamethasone test combined with the administration of ovine corticotrophin-releasing hormone in childhood cushing syndrome

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 11, 2008, Pages 4323-4330

  Batista, Dalia L ^a,b   Courcoutsakis, Nikos ^a,c   Riar, Jehan ^a,b   Keil, Margaret F ^a   Stratakis, Constantine A ^a,b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; HYDROCORTISONE;

ADOLESCENT; ARTICLE; BODY MASS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CUSHING SYNDROME; CUSHINGOID SYNDROME; DISEASE SEVERITY; FEMALE; HISTOPATHOLOGY; HUMAN; HYDROCORTISONE BLOOD LEVEL; MALE; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; URINARY EXCRETION;

OVIS;

EID: 57349115639     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0985     Document Type: Article

References (33)

1. Lindholm JF, Juul S, Jorgensen JO, Astrup J, Bjerre P, Feldt-Rasmussen U, Hagen C, Jorgensen J, Kosteljanetz M, Kristensen L, Launberg P, Schmidt K, Weeke J 2001 Incidence and late prognosis of Cushing's syndrome: a population-based study. J Clin Endocrinol Metab 86:117-123
2. Newell-Price JF, Trainer PF, Besser MF, Grossman AB 1998 The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 19:647-672
3. Magiakou MA, Mastorakos G, Oldfield EH, Gomez MT, Doppman JL, Cutler Jr GB, Nieman LK, Chrousos GP 1994 Cushing's syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med 331:629-636
4. Savage MO, Lienhardt AF, Lebrethon MC, Johnston LB, Huebner A, Grossman AB, Afsher F, Plowman PN, Besser GM 2001 Cushing's disease in childhood: presentation, investigation, treatment and long-term outcome. Horm Res 55:24-30
5. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, Fava GA, Findling JW, Gaillard RC, Grossman AB, Kola B, Lacroix A, Mancini T, Mantero F, Newell-Price J, Nieman LK, Sonino N, Vance ML, Giustina A, Boscaro M 2003 Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 88:5593-5602
6. Nieman LK 2002 Diagnostic tests for Cushing's syndrome. Ann NY Acad Sci 970:112-118
7. Boscaro MF, Barzon L, Fallo F, Sonino N 2001 Cushing's syndrome. Lancet 357:783-791
8. Findling JW, Raff H 2005 Screening and diagnosis of Cushing's syndrome. Endocrinol Metab Clin North Am 34:385-402
9. Gafni RI, Papanicolau DA, Nieman LK 2000 Nighttime salivary cortisol measurement as a simple, noninvasive, outpatient screening test for Cushing's syndrome in children and adolescents. J Pediatr 137:30-35
10. Martinelli Jr CE, Sade SL, Oliveira EB, Daneluzzi JC, Moreira AC 1999 Salivary cortisol for screening of Cushing's syndrome in children. Clin Endocrinol 51:67-71
11. Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK 1993 Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states. JAMA 269:2232-2238
12. Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK 1998 The dexamethasone-suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology. J Clin Endocrinol Metab 83:348-352
13. Pecori Giraldi F, Pivonello R, Ambrogio AG, De Martino MC, De Martin M, Scacchi M, Colao A, Toja PM, Lombardi G, Cavagnini F 2007 The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. Clin Endocrinol (Oxf) 66:251-257
14. Martin N, Dhillo W, Banerjee A, Abdulali A, Jayasena CN, Donaldson M, Todd JF, Meeran K 2006 Comparison of the dexamethasone-suppressed corticotropin-releasing hormone test and low dose dexamethasone suppression test in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 91:2582-2586
15. Erickson D, Natt N, Nippoldt N, Young Jr WF, Carpenter PC, Petterson T, Christianson T 2007 Dexamethasone-suppressed corticotropin-releasing hormone stimulation test for diagnosis of mild hypercortisolism. J Clin Endocrinol Metab 92:2972-2976
16. Gatta B, Chabre O, Cortet C, Martinie M, Corcuff JB, Roger P, Tabarin A 2007 Reevaluation of the combined dexamethasone suppression-corticotropin- releasing hormone test for differentiation of mild Cushing's disease from pseudo-Cushing's syndrome. J Clin Endocrinol Metab 92:4290-4293
17. Hammer LD, Kraener HC, Wilson DM, Ritter PL, Dornbusch SM 1991 Standardized percentile curves for body-mass index for children and adolescents. Am J Dis Childhood 145:259-263
18. Pietrobelli A, Faith MS, Allison DB, Gallagher D, Chiurnello G, Heymsfield SB 1998 Body mass index as a measure of adiposity among children and adolescents: a validation study. J Pediatr 132:204-210
19. Dhuper S, Cohen HW, Daniel J, Gumidyala P, Agarwalla V, St Victor R, Dhuper S 2007 Utility of the modified ATP III defined metabolic syndrome and severe obesity as predictors of insulin resistance in overweight children and adolescents: a cross-sectional study. Cardiovasc Diabetol 6:1-9
20. Caprio S 2005 Definitions and pathophysiology of the metabolic syndrome in obese children and adolescents. Int J Obes 29(Suppl 2):S24-S25
21. Gomez MT, Malozowski S, Winterer J, Vamvakopoulos NC, Chrousos GP 1991 Urinary-free cortisol values in normal children and adolescents. J Pediatr 118:256-258
22. Streeten DH, Faas FH, Elders MJ, Dalakos TG, Voorhess M 1975 Hypercortisolism in childhood: shortcomings of conventional diagnostic criteria. Pediatrics 56:797-803
23. Papanicolaou DA, Yanovski JA, Cutler Jr GB, Chrousos GP, Nieman LK 1998 A single midnight serum cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing states. J Clin Endocrinol Metab 83:1163-1167
24. Nieman LK, Oldfield EH, Wesley R, Chrousos GP, Loriaux DL, Cutler Jr GB 1993 A simplified morning ovine corticotropin-releasing hormone stimulation test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 77:1308-1312
25. Batista DL, Riar R, Keil MF, Stratakis CA 2007 Diagnostic tests for children who are referred for the investigation of Cushing syndrome. Pediatrics 120:e575-e86
26. Dichek HL, Nieman LK, Oldfield EH, Pass HI, Malley JD, Cutler Jr GB 1994 A comparison of the standard high-dose dexamethasone suppression test and the overnight 8-mg dexamethasone suppression test for the differential diagnosis of adrenocorticotropin-dependent Cushing's syndrome. J Clin Endocrinol Metab 78:418-422
27. Pasquali R, Vicennati V, Cacciaru M, Pagotto U 2006 The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome. Ann NY Acad Sci 1083:111-128
28. Ljung T, Andersson B, Bengtsson BA, Bjorntorp P, Marin P 1996 Inhibition of cortisol secretion by dexamethasone in relation to body fat distribution: a dose-response study. Obes Res 4:277-282
29. Fernandez-Real JM, Grasa M, Casamitjana R, Pugeat M, Barret C, Ricart W 2002 Corticosteroid binding globulin: a new target for cortisol-driven obesity. J Clin Endocrinol Metab 87:4686-4690
30. Gorges R, Knappe G, Gerl H, Ventz M, Stahl F 1999 Diagnosis of Cushing's syndrome: re-evaluation of midnight plasma cortisol vs urinary free cortisol and low-dose dexamethasone suppression test in a large patient group. J Endocrinol Invest 22:241-249
31. Barrou Z, Guiban D, Maroufi A, Fournier C, Dugue M-A, Luton J-P, Thomopoulos P 1996 Overnight dexamethasone suppression test: comparison of plasma and salivary cortisol measurement for the screening of Cushing's syndrome. Eur J Endocrinol 134:93-96
32. Cronin C, Igoe D, Duffy MJ, Cunningham SK, McKenna TJ 1990 The overnight dexamethasone test is a worthwhile screening procedure. Clin Endocrinol (Oxf) 33:27-33
33. Findling JM, Raff H, Aron DC 2004 The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing's syndrome. J Clin Endocrinol Metab 289:1222-1226