Altered cyclophosphamide and thiotepa pharmacokinetics in a patient with moderate renal insufficiency

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 2, 2009, Pages 375-379

  Ekhart, Corine ^a   Kerst, J Martijn ^b   Rodenhuis, Sjoerd ^b   Beijnen, Jos H ^a,c   Huitema, Alwin D R ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cyclophosphamide; Pharmacokinetics; Renal insufficiency; Thiotepa

Indexed keywords

4 HYDROXYCYCLOPHOSPHAMIDE; CARBOPLATIN; CYCLOPHOSPHAMIDE; TEPA; THIOTEPA;

ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CANCER CHEMOTHERAPY; CASE REPORT; CREATININE CLEARANCE; DIARRHEA; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; DRUG EXPOSURE; DRUG MEGADOSE; EWING SARCOMA; HUMAN; KIDNEY FAILURE; MALE; MUCOSA INFLAMMATION; PRIORITY JOURNAL; SIDE EFFECT;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CYCLOPHOSPHAMIDE; DRUG INTERACTIONS; HUMANS; MALE; METABOLIC CLEARANCE RATE; RENAL INSUFFICIENCY; SARCOMA, EWING'S; THIOTEPA;

EID: 57149145037     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0757-z     Document Type: Article

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