Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS)

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 854, Issue 1-2, 2007, Pages 345-349

  Ekhart, Corine ^a   Gebretensae, Abadi ^a   Rosing, Hilde ^a   Rodenhuis, Sjoerd ^b   Beijnen, Jos H ^a,b,c   Huitema, Alwin D R ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

^b ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

4 Hydroxycyclophosphamide; Cyclophosphamide; LC MS MS

Indexed keywords

CONCENTRATION (PROCESS); CYTOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMALS; MASS SPECTROMETRY; METABOLITES;

4-HYDROXYCYCLOPHOSPHAMIDE; CYCLOPHOSPHAMIDE; PHARMACOLOGY;

DRUG PRODUCTS;

4 HYDROXYCYCLOPHOSPHAMIDE; ACETONITRILE; AMMONIUM HYDROXIDE; CYCLOPHOSPHAMIDE; METHANOL; SEMICARBAZIDE; WATER;

ACCURACY; ARTICLE; BLOOD SAMPLING; BLOOD SMEAR; COHORT ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PARTICLE SIZE; PRIORITY JOURNAL; STANDARD;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOPHOSPHAMIDE; HUMANS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34250699447     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.04.024     Document Type: Article

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