Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs

International Journal of Pharmaceutics

Volumn 365, Issue 1-2, 2009, Pages 190-199

  Lee, Kathy W Y ^a   Nguyen, Tri Hung ^a   Hanley, Tracey ^b   Boyd, Ben J ^a  

^a MONASH UNIVERSITY   (Australia)

^b AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

Cubic phase; Hexagonal phase; Hydrophilic drug; Liquid crystal; Oral absorption; Phytantriol; Sustained release

Indexed keywords

ALLURA RED AC; ALPHA TOCOPHEROL; CARBON 14; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GLUCOSE; GLYCEROL OLEATE; HEXADECANE; NANOMATERIAL; PHYTANTRIOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DIFFUSION; DRUG ABSORPTION; DRUG RELEASE; HYDROPHILICITY; LIQUID CRYSTAL; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; AZO COMPOUNDS; DELAYED-ACTION PREPARATIONS; DEXTRANS; DIFFUSION; DRUG DELIVERY SYSTEMS; FATTY ALCOHOLS; FLUORESCEIN-5-ISOTHIOCYANATE; GLUCOSE; GLYCERIDES; LIQUID CRYSTALS; MALE; MOLECULAR WEIGHT; NANOSTRUCTURES; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN E;

EID: 57149138029     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.08.022     Document Type: Article

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