Formulation optimization of an indomethacin-containing photocrosslinked polyacrylic acid hydrogel as an anti-inflammatory patch

AAPS PharmSciTech

Volumn 9, Issue 3, 2008, Pages 1038-1045

  Nishikawa, Masato ^a   Onuki, Yoshinori ^a   Isowa, Koichi ^b   Takayama, Kozo ^a  

^a HOSHI UNIVERSITY   (Japan)

^b Center of Japan Biological Chemistry Co Ltd   (Japan)

Author keywords

Dermatological patch adhesive; Formulation optimization; Indomethacin; Multivariate spline interpolation; Photocross linked hydrogel

Indexed keywords

INDOMETACIN; MENTHOL; POLYACRYLIC ACID; POLYMACON; POLYSORBATE 80;

ADHESION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG PENETRATION; DRUG STABILITY; MALE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PROCESS OPTIMIZATION; RAT; SKIN PERMEABILITY; TRANSDERMAL PATCH; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ACRYLIC RESINS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; HYDROGELS; INDOMETHACIN; MALE; PHOTOCHEMISTRY; RATS; SKIN; ULTRAVIOLET RAYS;

EID: 57149131810     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9141-x     Document Type: Article

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