Neurobehavioural changes in rats after neonatal anoxia: Effect of antioxidant stobadine pretreatment

Neuroendocrinology Letters

Volumn 27, Issue SUPPL. 2, 2006, Pages 82-85

  Ujházy, Eduard ^a   Schmidtová, Miroslava ^a   Dubovický, Michal ^a   Navarová, Jana ^a   Brunkerová, Ingrid ^b   Vvv, Mojmír ^a  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

Author keywords

Antioxidant; Behaviour; Neonatal anoxia; Rat; Stobadine

Indexed keywords

STOBADINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; BEHAVIOR CHANGE; BODY GROWTH; COGNITION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG TOLERABILITY; FEMALE; GESTATIONAL AGE; HYPERACTIVITY; MALE; MATURATION; MOTONEURON; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; OPEN FIELD TEST; PERINATAL PERIOD; POSTNATAL CARE; PRENATAL DRUG EXPOSURE; RAT; REFLEX; RISK REDUCTION; WISTAR RAT;

EID: 34047241392     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (18)

1. Balonová T, Zeljenková D, Ďurišová M, Nosál' R, Jakubovský J, Líška J, Štolc S. Reproductive toxicity studies with cis-(-)-2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-1 H-pyrido-[4,3-b]indole dipalmitate in rats. Arzneimittelforschung. 1991; 1:1-5.
2. Barkov NK The mechanism of action of carbidine. Farmakol Toksikol. 1973; 2:154-7.
3. van Bel F, Shadid M, Moison RM, Dorrepaal CA, Fontijn J, Monteiro L. Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity. Pediatrics. 1998; 10:185-93.
4. Clancy RR, McGaurn SA, Goin JE, Hirtz DG, Norwood WI, Gaynor JW. Allopurinol neurocardiac protection trial in infants undergoing heart surgery using deep hypothermic circulatory arrest. Pediatrics. 2001; 108:61-70.
5. Dubovický M, Mach M, Ujházy E, Juránek I, Navarová J, Kovačovský P, Rychlík I, Sadloňová I. Effect of neonatal anoxia on neurobehavioral development of rats. Biologia. 2000; 55(Suppl. 8):27-32.
6. Dubovický M, Ujházy E, Kovačovský P, Rychlík I, Navarová J, Janšák J. Antioxidant stobadine and neurobehavioural development of the rat offspring. Gen. Physiol Biophys. 1999; 18:41-7.
7. Horáková L, Štolc S. Antioxidant and pharmacodynamic effects of pyridoindole stobadine. Gen Pharmacol. 1998; 5:627-38.
8. Chemical Abstracts, Index Guide, American Chemical Society, Columbus, Ohio, USA, 1987.
9. Krištofová A, Ujházy E, Bezek Š, Balonová T, Nosál' R. Stobadine toxicity and transplacental movement. Arch Toxicol Suppl. 1991; 14:280-3.
10. Low JA. Determining the contribution of asphyxia to brain damage in the neonate. J Obstet Gynaecol Res. 2004; 30(4):276-86.
11. Mach M. Ethological approaches in pharmacology and toxicology: prenatal antioxidant supplementation during intrauterine hypoxia in rats and behavioral effects of acetylcholinesterase inhibitors in mice. Inst. Exp. Pharmacol. SASc. Bratislava, Slovakia. 2006, PhD. Thesis, p. 134.
12. Manson JM, Kang YJ. Test methods for assessing female reproductive and developmental toxicology. In. Hayes AW, editor. Principles and Methods in Toxicology, Raven Press, New York, 1989; 311-59.
13. Metyš J, Metyšová J, Valchař M, Dlhonožková M. Effect of stobadine (-)-cis base on nervous system. Stobadine, a new medicine with antiarrhythmic, protective and antihypoxic effect on myocardium. Inst. Exp. Pharmacol. SASc., Bratislava, Slovakia. 1985; 450-75, 794-6.
14. Miháliková K, Ujházy E, Braxatorisová E, Kučera P. Comparative teratological study of stobadine in vivo and in vitro. Toxicol in Vitro. 1993; 7:803-7.
15. Nakai A, Shibazaki Y,Taniuchi Y, Oya A, Asakura H, KoshinoT. Vitamins ameliorate secondary mitochondrial failure in neonatal rat brain. Ped Neurol. 2002; 27:30-5.
16. Štolc S, Vlkolinský R, Pavlásek J. Neuroprotection by the pyridoindole stobadine: a minireview. Brain Res Bull. 1997; 5:335-40.
17. Ujházy E, Dubovický M, Fáberová V, Zemánek M, Šoltés L, Gajdošík A, Eybl V. Placental transfer of the antioxidant stobadine at different gestational stages in rabbits. Methods Find Exp Clin Pharmacol. 2000; 22(9):683-8.
18. Ujházy E, Mach M, Dubovický M, Navarová J, Brucknerová I, Juránek I. Effect of pyridoindole stobadine on maternal and embryo-foetal toxicity induced by phenytoin in rats. Biologia. 2005; 60(Suppl. 17):57-60.