The disposition and pharmacokinetics of Dioscorea nipponica Makino extract in rats

African Journal of Biotechnology

Volumn 7, Issue 22, 2008, Pages 4015-4018

  Ren, Hong ^a   Jian Ping, Chen ^a,b   Bin Yan, Tan ^a   Dong Mei, Wang ^a   Shu Hai, Lin ^a   Zhang, Y P ^b   Yang, D P ^a   Loo, T Y Wings ^c   Yeung, H S Barry ^d   Jin, Miaozhen ^e   Li, Xiaofang ^e  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

^c TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

3H labeled; Disposition; Pharmacokinetics; Total saponins of dioscorea

Indexed keywords

DIOSCOREA NIPPONICA EXTRACT; PLANT EXTRACT; TRITIUM; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; DIOSCOREA NIPPONICA; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; FECES ANALYSIS; HEART; INTESTINE WALL; KIDNEY; LIVER; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; NONHUMAN; RADIATION DETECTION; RAT; SINGLE DRUG DOSE; SMALL INTESTINE; SPRAGUE DAWLEY RAT; STOMACH WALL; TIME TO MAXIMUM PLASMA CONCENTRATION;

DIOSCOREA; DIOSCOREA NIPPONICA; RATTUS;

EID: 57149120541     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Cao X, Yao Z, Chen H, Dai Y, Sun P, Ye W, Yao X (2007). Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study. J. Biomed. Chromatogr. Nov 14.
2. Chiang HC, Wang JJ, Wu RT (1992). Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. J. Anticancer Res. 5: 1475-1478.
3. Han GZ (1999). Drug metabolism and pharmacokinetics of Chinese herbal medicine. Press of Science and Technology of Chinese Medicine: Beijing, China.
4. He X, Qiao A, Wang X, Liu B, Jiang M, Su L, Yao X (2006). Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines. J. Steroids. 9: 828-833.
5. Li K, Tang Y, Fawcett JP, Gu J, Zhong D (2005). Characterization of the pharmacokinetics of dioscin in rat. J. Steroids. 8: 525-530.
6. Li K, Wang Gu Y, J, Chen X, Zhong D (2005). Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 817(2): 271-5.
7. Lin SH, Wang DM, Yang DP, Yao J, Tong Y, Chen JP (2007). Characterization of steroidal saponins in crude extract form Dioscorea Nipponica Makino by liquid chromatography tandem multistage mass spectrometry. J. Analyt. Chim. Acta 9: 98-106.
8. Liu ZR, Zou WJ, Wang RZ, Zhou ZZ (2004). Clinic application of Di'ao Xin Xue Kang capsule for ten years in China. Chin. J. Tradit. Chin. Med. Pharm. 19: 620-622.
9. Ma HY, Zhao ZT, Wang LJ, Wang Y, Zhou QL, Wang BX (2002). comparative study on anti-Hypercholesterol activity od diosgenin and total saponin of Dioscorea panthaica. China J. Chin. Mat. Med. 7: 528-531.
10. Mi Q, Lantvit D, Reyes-Lim E, Chai H, Zhao W, Lee IS, Peraza-Sánchez S, Ngassapa O, Kardono LB, Riswan S, Hollingshead MG, Mayo JG, Farnsworth NR, Cordell GA, Kinghorn AD, Pezzuto JM (2002). Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests. J. Nat. Prod. 6: 842-850.
11. Yoshikawa M, Xu F, Morikawa T, Pongpiriyadacha Y, Nakamura S, Asao Y, Kumahara A, Matsuda H (2007). Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer. J. Chem. Pharm. Bull. 2: 308-316.