Postinjury immune monitoring: Can multiple organ failure be predicted?

Current Opinion in Critical Care

Volumn 14, Issue 6, 2008, Pages 666-672

  Visser, Tjaakje ^a   Pillay, Janesh ^a   Koenderman, Leo ^a   Leenen, Luke P H ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cytokine; Injury; Multiple organ failure; Polymorphonuclear leukocyte; Predictive marker

Indexed keywords

CYTOKINE; MARKER;

DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE MARKER; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; INJURY; MONITORING; MULTIPLE ORGAN FAILURE; PARAMETER; PREDICTION; PROGNOSIS; REVIEW; SENSITIVITY AND SPECIFICITY; SURVIVAL;

BIOLOGICAL MARKERS; CRITICAL ILLNESS; CYTOKINES; HUMANS; IMMUNE SYSTEM; INFLAMMATION; MULTIPLE ORGAN FAILURE; NEUTROPHILS; PROGNOSIS; RISK FACTORS; SURVIVAL ANALYSIS; TIME FACTORS; WOUNDS AND INJURIES;

EID: 57149104401     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e3283196522     Document Type: Review

References (50)

1. Maier B, Lefering R, Lehnen M, Laurer HL. Early versus late onset of multiple organ failure is associated with differing patterns of plasma cytokine biomarker expression and outcome after severe trauma. Shock 2007; 28:668-674. The authors in this study meticulously describe the immunological events after trauma and it should be considered as a baseline study for everyone interested in the immunological reaction after trauma.
2. Sauaia A, Moore FA, Moore EE. Multiple organ failure can be predicted as early as 12 h after injury. J Trauma 1998; 45:291-301; discussion 301-293.
3. Acosta JA, Yang JC, Winchell RJ. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg 1998; 186:528-533.
4. Gennarelli TA, Champion HR, Copes WS, Sacco WJ. Comparison of mortality, morbidity, and severity of 59713 head injured patients with 114447 patients with extracranial injuries. J Trauma 1994; 37:962-968.
5. Sauaia A, Moore FA, Moore EE. Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38:185-193.
6. Goris RJ, te Boekhorst TP, Nuytinck JK, Gimbrere JS. Multiple-organ failure. Generalized autodestructive inflammation? Arch Surg 1985; 120:1109-1115.
7. Nuytinck HK, Offermans XJ, Kubat K, Goris RJ. Whole body inflammation in trauma patients; an autopsy study. Prog Clin Biol Res 1987; 236A:55-61.
8. Moore FA, Sauaia A, Moore EE. Postinjury multiple organ failure: a bimodal phenomenon. J Trauma 1996; 40:501-510; discussion 510-502.
9. Lausevic Z, Lausevic M, Trbojevic-Stankovic J. Predicting multiple organ failure in patients with severe trauma. Can J Surg 2008; 51:97-102. In this prospective study the authors evaluated several immunological and clinical factors in patients after trauma. They identify several parameters with a high correlation for subsequent MOF. First day high levels of IL-6 and fourth day clinical SIRS score are highly related with the development of MOF.
10. Nyman KM, Uhl W, Forsstrom J. Serum phospholipase A2 in patients with multiple organ failure. J Surg Res 1996; 60:7-14.
11. Waydhas C, Nast-Kolb D, Trupka A. Posttraumatic inflammatory response, secondary operations, and late multiple organ failure. J Trauma 1996; 40:624-630; discussion 630-621.
12. Roumen RM, Redl H, Schlag G. Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma. Crit Care Med 1995; 23:474-480.
13. Wanner GA, Keel M, Steckholzer U. Relationship between procalcitonin plasma levels and severity of injury, sepsis, organ failure, and mortality in injured patients. Crit Care Med 2000; 28:950-957.
14. Meisner M, Adina H, Schmidt J. Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 2006; 10:R1.
15. Nast-Kolb D, Waydhas C, Gippner-Steppert C. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997; 42:446-454; discussion 454-445.
16. Pape HC, van Griensven M, Rice J. Major secondary surgery in blunt trauma patients and perioperative cytokine liberation: determination of the clinical relevance of biochemical markers. J Trauma 2001; 50:989-1000.
17. Neidhardt R, Keel M, Steckholzer U. Relationship of interleukin-10 plasma levels to severity of injury and clinical outcome in injured patients. J Trauma 1997; 42:863-870; discussion 870-861.
18. Giannoudis PV. Current concepts of the inflammatory response after major trauma: an update. Injury 2003; 34:397-404.
19. Keel M, Trentz O. Pathophysiology of polytrauma. Injury 2005; 36:691-709.
20. Gosling P, Dickson GR. Serum C-reactive protein in patients with serious trauma. Injury 1992; 23:483-486.
21. Mimoz O, Benoist JF, Edouard AR. Procalcitonin and C-reactive protein during the early posttraumatic systemic inflammatory response syndrome. Intensive Care Med 1998; 24:185-188.
22. Dorizzi RM, Polati E, Sette P. Procalcitonin in the diagnosis of inflammation in intensive care units. Clin Biochem 2006; 39:1138-1143.
23. Luzzani A, Polati E, Dorizzi R. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 2003; 31:1737-1741.
24. Mokart D, Merlin M, Sannini A. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anaesth 2005; 94:767-773.
25. Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth 2005; 95:130-139.
26. Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy: its pathophysiology and treatment in the injured patient. World J Surg 2007; 31:1055-1064.
27. Park MS, Saunas J, Wade CE, et al. Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients. J Trauma 2008; 64 (2 Suppl):S188-S194.
28. Siegel JH, Rivkind Al, Dalai S, Goodarzi S. Early physiologic predictors of injury severity and death in blunt multiple trauma. Arch Surg 1990; 125:498-508.
29. Perl M, Gebhard F, Knoferl MW. The pattern of preformed cytokines in tissues frequently affected by blunt trauma. Shock 2003; 19:299-304.
30. Hildebrand F, Pape HC, Krettek C. The importance of cytokines in the posttraumatic inflammatory reaction. Unfallchirurg 2005; 108:793-794; 796-803.
31. Giannoudis PV, Smith RM, Banks RE. Stimulation of inflammatory markers after blunt trauma. Br J Surg 1998; 85:986-990.
32. Strecker W, Gebhard F, Perl M. Biochemical characterization of individual injury pattern and injury severity. Injury 2003; 34:879-887.
33. Ogura H, Tanaka H, Koh T. Priming, second-hit priming, and apoptosis in leukocytes from trauma patients. J Trauma 1999; 46:774-781; discussion 781-773.
34. Harwood PJ, Giannoudis PV, van Griensven M. Alterations in the systemic inflammatory response after early total care and damage control procedures for femoral shaft fracture in severely injured patients. J Trauma 2005; 58:446-452; discussion 452-444.
35. Pape H, Stalp M, v Griensven M. Optimal timing for secondary surgery in polytrauma patients: an evaluation of 4314 serious-injury cases. Chirurg 1999; 70:1287-1293.
36. Takala A, Jousela I, Takkunen O. A prospective study of inflammation markers in patients at risk of indirect acute lung injury. Shock 2002; 17:252-257.
37. Matsushima A, Ogura H, Fujita K. Early activation of gammadelta T lymphocytes in patients with severe systemic inflammatory response syndrome. Shock 2004; 22:11-15.
38. Botha AJ, Moore FA, Moore EE. Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failure. J Trauma 1995; 39:411-417.
39. Pallister I, Dent C, Topley N. Increased neutrophil migratory activity after major trauma: a factor in the etiology of acute respiratory distress syndrome? Crit Care Med 2002; 30:1717-1721.
40. Biffl WL, Moore EE, Zallen G. Neutrophils are primed for cytotoxicity and resist apoptosis in injured patients at risk for multiple organ failure. Surgery 1999; 126:198-202.
41. Pallister I, Bhatia R, Katpalli G. Alteration of polymorphonuclear neutrophil surface receptor expression and migratory activity after isolation: comparison of whole blood and isolated PMN preparations from normal and postfracture trauma patients. J Trauma 2006; 60:844-850.
42. Pallister I, Topley N. Chemiluminescence: comparison of whole blood with isolated polymorphonuclear leukocytes after major trauma. J Trauma 2004; 57:347-351.
43. Pacher R, Redl H, Woloszczuk W. Plasma levels of granulocyte elastase and neopterin in patients with MOF. Prog Clin Biol Res 1989; 308:683-688.
44. Bhatia R, Dent C, Topley N, Pallister I. Neutrophil priming for elastase release in adult blunt trauma patients. J Trauma 2006; 60:590-596.
45. Bhatia RK, Pallister I, Dent C. Enhanced neutrophil migratory activity following major blunt trauma. Injury 2005; 36:956-962.
46. Pillay J, Hietbrink F, Koenderman L, Leenen LP. The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils. Injury 2007; 38:1365-1372. This study correlates different leukocyte phenotypes with the severity of the immunological reaction after trauma. It is suggested that the phenotype readout can be indicative for the immunological state, when using them together in a single overview.
47. Botha AJ, Moore FA, Moore EE. Postinjury neutrophil priming and activation: an early vulnerable window. Surgery 1995; 118:358-364; discussion 364-355.
48. Hietbrink F, Oudijk EJ, Braams R. Aberrant regulation of polymorphonuclear phagocyte responsiveness in multitrauma patients. Shock 2006; 26:558-564.
49. Coffer PJ, Koenderman L. Granulocyte signal transduction and priming: cause without effect? Immunol Lett 1997; 57:27-31.
50. Donnelly SC, Haslett C, Dransfield I. Role of selectins in development of adult respiratory distress syndrome. Lancet 1994; 344:215-219.