Deposition-dependent normal ranges for radioaerosol assessment of lung mucus clearance

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 21, Issue 4, 2008, Pages 371-380

  Agnew, John E ^a   Hasani, Amir ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Aerosol deposition; Mucociliary clearance; Tracheobronchial clearance

Indexed keywords

PLACEBO;

ADULT; AEROSOL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; HUMAN; INHALATION; LUNG CLEARANCE; MUCUS; RESPIRATORY TRACT MUCOSA;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AEROSOLS; AGE FACTORS; AGED; AREA UNDER CURVE; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; MUCOCILIARY CLEARANCE; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 57149091612     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2007.0642     Document Type: Article

References (44)

1. Agnew JE, Sutton PP, Pavia D, and Clarke SW: Radioaerosol assessment of mucociliary clearance: towards definition of a normal range. Br J Radiol. 1986;59:147-151.
2. Ilowite JS, Smaldone GC, Perry RJ, Bennett WD, and Foster WM: Relationship between tracheobronchial particle clearance rates and sites of initial deposition in man. Arch Environ Health. 1989;44: 267-273.
3. Agnew JE: Characterizing lung aerosol penetration. J Aerosol Med. 1991;4:237-249.
4. Hasani A, Toms N, Agnew JE, Sarno M, Harrison AJ, and Dilworth P: The effect of inhaled tiotropium bromide on lung mucociliary clearance in patients with COPD. Chest. 2004;125:1726-1734.
5. Smaldone GC, and Messina MS: Enhancement of particle deposition by flow-limiting segments in humans. J Appl Physiol. 1985;59:509-514.
6. Agnew JE, Bateman JRM, Pavia D, and Clarke SW: A model for assessing bronchial mucus transport. J Nuclear Med. 1984;24:170-176.
7. International Commission on Radiological Protection: Human respiratory tract model for radiological protection. Ann ICRP. 1994;24:1-482.
8. Snedecor GW, and Cochran WG. Statistical Methods (6th ed.). Iowa State University Press, Ames, IA, pp. 135-171, 1967.
9. Altman DG, and Gardner MJ: Regression and correlation In: DG Altman, D Machin, TN Bryant, and MJ Gardner (eds). Statistics with Confidence. BMJ Books, London, pp. 73-92, 2000.
10. Fisher RA: Statistical methods for research workers (13th ed.). Oliver and Boyd, Edinburgh, pp. 197-204, 1958.
11. Pavia D, Bateman JRM, Lennard-Jones AM, Agnew JE, and Clarke SW: Effect of selective and non-selective beta blockade on pulmonary function and tracheobronchial mucociliary clearance in healthy subjects. Thorax. 1986;41:301-305.
12. Lai CK, Polosa R, Pavia D, Hasani A, Agnew JE, and Clarke SW: Effect of inhaled 15-(s)-hydroxyeicosatetraenoic acid on tracheobronchial clearance in normal human airways. Thorax. 1991;46:446-448.
13. Hasani A, Spiteri MA, Pavia D, Lopez-Vidriero MT, Agnew JE, and Clarke SW: Effect of temazepam on tracheobronchial mucus clearance. Thorax. 1992;47:298-300.
14. Polosa R, Hasani A, Pavia D, Agnew JE, Lai CK, Clarke SW, and Holgate ST: Acute effect of inhaled bradykinin on tracheobronchial clearance in normal humans. Thorax. 1992;47:952-956.
15. Hasani A, Pavia D, Spiteri MA, Yeo CT, Agnew JE, Clarke SW, and Chung KF: Inhaled frusemide does not affect lung mucociliary clearance in healthy and asthmatic subjects. Eur Respir J. 1994;7:1497-1500.
16. Yeates DB, Gerrity TR, and Garrard CS: Characteristics of tracheobronchial deposition and clearance in man. Ann Occup Hyg. 1982;26:245-257.
17. Stahlhofen W, Scheuch G, and Bailey MR: Measurement of the tracheobronchial clearance of particles after aerosol bolus inhalation. Ann Occup Hyg. 1994;38:189-196.
18. Fleming JS, Epps BP, Conway JH, and Martonen TB: Comparison of SPECT aerosol deposition data with a human respiratory tract model. J Aerosol Med. 2006;19:268-278.
19. Tossici-Bolt L, Fleming JS, Conway JH, and Martonen TB: An analytical technique to recover the third dimension in planar imaging of inhaled aerosols-(2) estimation of the deposition per airway generation. J Aerosol Med. 2007;20:127-140.
20. Im Hof V, and Patrick G: Particle retention and clearance. J Aerosol Med. 1994;7:39-47.
21. Anderson M, Philipson K, Svartengren M, and Camner P: Human deposition and clearance of 6-μm particles inhaled with an extremely low flow rate. Exp Lung Res. 1995;21:187-195.
22. Scheuch G, Stahlhofen W, and Heyder J: An approach to deposition and clearance measurements in human airways. J Aerosol Med. 1996;9:35-41.
23. Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Häussinger H, and Kreyling WG. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med. 2008;177:426-432.
24. Möller W, Häussinger H, Winkler-Heil R, Stahlhofen W, Meyer T, Hofmann W, and Heyder J. Mucociliary and longterm particle clearance in the airways of healthy non-smoker subjects. J Appl. Physiol. 2004;97:2200-2206.
25. Lippmann M, and Albert RE: The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. Am Ind Hyg Assoc J. 1969;30:257-275.
26. Sanchis J, Dolovich M, Chalmers R, and Newhouse M: Quantitation of regional aerosol clearance in the normal human lung. J Appl Physiol. 1972;33:757-762.
27. Camner P, and Philipson K: Human alveolar deposition of 4μm Teflon particles. Arch Environ Health. 1978;36:181-185.
28. Stahlhofen W, Gebhart J, and Heyder J: Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am Ind Hyg Assoc J. 1980;41:385-398.
29. Wilkey DD, Lee PS, Hass FJ, Gerrity TR, Yeates DB, and Lourenco RV: Mucociliary clearance of deposited particles from the human lung: intra- and inter-subject reproductivity, total and regional lung clearance, and model comparisons. Arch Environ. Health. 1980;35:294-303.
30. Smaldone GC, Perry RJ, Bennett WD, Messina MS, Zwang J, and Ilowite J: Interpretation of "24 hour lung retention" in studies of mucociliary clearance. J Aerosol Med. 1988;1:11-20.
31. Fazio F, and Jones T: Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m. Br Med J. 1975;3:673-676.
32. Secker-Walker RH: Pulmonary physiology, pathology, and ventilation-perfusion studies. J Nuclear Med. 1978;19:961-968.
33. Modell HI, and Graham MM: Limitations of Kr-81m for quantification of ventilation scans. J Nucleic Med. 1982;23:301-305.
34. Lythgoe MF, Davies H, Kuba A, Toth-Abonyi M, and Gordon I: Can dynamic krypton-81m imaging separate regional ventilation and volume? J Nuclear Med. 1992;33:1935-1939.
35. Peters AM, and Myers MJ: Regional ventilation. In: Physiological Measurement with Radionuclides in Clinical Practice. Oxford University Press, New York. pp. 152-153, 1998.
36. Schor RA, Shames DM, Weber PM, and DosRemedios IV: Regional ventilation studies with Kr-81m and Xe-133: A comparative analysis. J Nuclear Med. 1978;719:348-353.
37. Magnant J, Vecellio L, de Monte M, Grimbert D, Valat C, Boissinot E, Guilloteau D, Lemarie E, Diot P: Comparative analysis of different scintigraphic approaches to assess pulmonary ventilation. J Aerosol Med. 2006;19:148-159.
38. Ebert RV and Terracio MJ: The bronchiolar epithelium in cigarette smokers: observations with the scanning electron microscope. Am Rev Respir Dis. 1975;111:4-11.
39. Boers JE, Ambergen AW, and Thunnissen FBJM: Number and proliferation of Clara cells in normal human airway epithelium. Am J Respir Crit Care Med. 1999;159:1582-1591.
40. Tyner JW, Kim EY, Ide K, Pelletier MR, Roswit WT, Morton JD, Battaile JT, Patel AC, Patterson GA, Castro M, Spoor MS, You Y, Brody SL, and Holtzman MJ: Blocking airway mucous cell metaplasia by inhibiting antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest. 2006;116:309-321.
41. Agnew JE, Lopez-Vidriero MT, Pavia D, and Clarke SW: Functional small airways defence in symptomless cigarette smokers. Thorax. 1986;41:524-530.
42. Sturm R, and Hoffmann W. Stochastic modelling predictions for the clearance of insoluble particles from the tracheobronchial tree of the human lung. Bull Math Biol. 2007;69:395-415.
43. Foster WM, Langenback EG, Bergofsky EH. Dissociation in the mucociliary function of central and peripheral airways of asymptomatic smokers. Am Rev Respir Dis. 1985;132:633-639.
44. Del Donno M, Pavia D, Agnew JE, Lopez-Vidriero MT, and Clarke SW. Variability and reproducibility in the measurement of tracheobronchial clearance in healthy subjects and patients with different obstructive lung diseases. Eur Respir J. 1988;1:613-620.