Stochastic modeling predictions for the clearance of insoluble particles from the tracheobronchial tree of the human lung

Bulletin of Mathematical Biology

Volumn 69, Issue 1, 2007, Pages 395-415

  Sturm, Robert ^a   Hofmann, W ^b  

^a University of Salzburg ^*  (Austria)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Bronchial airways; Mucus layer; Particle deposition; Slow bronchial clearance; Stochastic model

Indexed keywords

ARTICLE; BIOLOGICAL MODEL; BRONCHUS; COMPARATIVE STUDY; HUMAN; MUCOCILIARY CLEARANCE; PARTICULATE MATTER; PHYSIOLOGY; STATISTICS;

BRONCHI; HUMANS; MODELS, BIOLOGICAL; MUCOCILIARY CLEARANCE; PARTICULATE MATTER; STOCHASTIC PROCESSES;

EID: 33846471896     PISSN: 00928240     EISSN: 15229602     Source Type: Journal    
DOI: 10.1007/s11538-006-9143-3     Document Type: Article

References (37)

1. Albert, R.E., Arnett, L.C., 1955. Clearance of radioactive dust from the human lung. AMA Arch. Ind. Health 12, 99-106.
2. Albert, R.E., Lippmann, M., Briscoe, W., 1969. The characteristics of bronchial clearance in humans and the effects of cigarette smoking. Arch. Env. Health 18, 738-755.
3. Anjilvel, S., Asgharian, B., 1995. A multiple-path model of particle deposition in the rat lung. Fund. Appl. Toxicol. 28, 41-50.
4. Asgharian, B., Hofmann, W., Miller, F.J., 2001. Mucociliary clearance of insoluble particles from the tracheobronchial airways of the human lung. J. Aerosol Sci. 32, 817-832.
5. Brain, J.D., Gehr, P., Karvet, R.I., 1984. Airway macrophages: The importance of the fixation method. Ann. Rev. Resp. Dis. 129, 823-826.
6. Cuddihy, R.G., Yeh, H.C., 1988. Respiratory tract clearance of particles and substances dissociated from particles. In: Mohr, U. (Ed.), Inhalation Toxicology: The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment. Springer, Berlin, pp. 169-193.
7. Gehr, P., Im Hof, V., Geiser, M., Schürch, S., 1991. The fate of particles deposited in the intrapulmonary conducting airways. J. Aerosol Med. 4, 349-361.
8. Geiser, M., Cruz-Orive, L., Im Hof, V., Gehr, P., 1990. Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionator. J. Microsc. 160, 75-88.
9. Hofmann, W., Martonen, T., Menaché, M., 1990. A dosimetric model for localised radon progeny accumulations at tracheobronchial bifurcations. Rad. Prot. Dosim. 30, 245-259.
10. Hofmann, W., Koblinger, L., 1992. Monte Carlo modeling of aerosol deposition in human lungs. Part III: Comparison with experimental data. J. Aerosol Sci. 23, 51-63.
11. Hofmann, W., Asgharian, B., Winkler-Heil, R., 2001a. Modeling intersubject variability of particle deposition in human lungs. J. Aerosol Sci. 33, 219-35.
12. Hofmann, W., Sturm, R., Asgharian, B., 2001b. Stochastic simulation of particle clearance in human bronchial airways. J. Aerosol Sci. 32(Suppl.), S807-S808.
13. Hofmann, W., Asgharian, B., 2003. The effect of lung structure on mucociliary clearance and particle retention in human and rat lungs. Toxicol. Sci. 73, 448-456.
14. Hofmann, W., Sturm, R., 2004. Stochastic model of particle clearance in human bronchial airways. J. Aerosol Med. 17, 73-89.
15. International Commission on Radiological Protection (ICRP), 1994. Human respiratory tract model for radiological protection. Publication 66. Ann. ICRP, Pergamon Press, Oxford, UK.
16. Iravani, J.D., Van As, A., 1972. Mucus transport in the tracheobronchial tree of normal and bronchitic rats. J. Pathol. 106, 81-93.
17. Koblinger, L., Hofmann, W., 1985. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys. Med. Biol. 30, 541-556.
18. Koblinger, L., Hofmann, W., 1990. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure. J. Aerosol Sci. 21, 661-674.
19. Lee, P.S., Gerrity, T.R., Hass, F.J., Lourenco, R.V., 1979. A model for tracheobronchial clearance of inhaled particles in man and a comparison with data. IEEE Trans. Biomed. Eng. 26, 624-630
20. Luchtel, D.L., 1976. Ultrastructural observations on the mucous layer in pulmonary airways. J. Cell Biol. 70, 350a.
21. Mercer, R.R., Russell M.L., Crapo, J.D., 1992. Mucous lining layers in human and rat airways. Ann. Rev. Resp. Dis. 145, 355.
22. Mercer, R.R., Russell, M.L., Roggli, V.L., Crapo, J.D., 1994. Cell number and distribution in human and rat airways. Am. J. Resp. Cell Mol. Biol. 10, 613-624.
23. Mussatto, D.J., Garrard, C.S., Lourenco, R.V., 1988. The effect of inhaled histamine on human tracheal mucus velocity and bronchial mucociliary clearance. Am. Rev. Resp. Dis. 138, 774-779.
24. National Council on Radiation Protection and Measurements (NCRP), 1997. Deposition, retention, and dosimetry of inhaled radioactive substances, Report No. 125, Oxford.
25. Oberdörster, G., 1988. Lung clearance of inhaled insoluble and soluble particles. J. Aerosol Med. 1, 289-330.
26. Raabe, O.G., Yeh, H.C., Schum, G.M., Phalen, R.F., 1976. Tracheobronchial geometry: Human, dog, rat, hamster - A compilation of selected data from the project respiratory tract deposition models. Report LF-53. Lovelace Foundation, Albuquerque, New Mexico.
27. Scheuch, G., Stahlhofen, W., Heyder, J., 1996. An approach to deposition and clearance measurements in human airways. J. Aerosol Med. 9, 35-41.
28. Stahlhofen, W., Gebhart, J., Rudolf, G., Scheuch, G., 1986. Measurement of lung clearance with pulses of radioactivity-labelled aerosols. J. Aerosol Sci. 17, 330-336.
29. Stahlhofen, W., Koebrich, R., Rudolf, G., Scheuch, G., 1990. Short-term and long-term clearance of particles from the upper human respiratory tract as a function of particle size. J. Aerosol Sci. 21(Suppl.), S407-S410.
30. Sturgess, J.M., 1977. The mucous lining of major bronchi in the rabbit lung. Am. Rev. Resp. Dis. 115, 819-827.
31. Sturm, R., Hofmann, W., 2003. Mechanistic interpretation of the slow bronchial clearance phase. Rad. Prot. Dosim. 105, 101-104.
32. Sturm, R., Hofmann, W., Scheuch, G., Sommerer, K., Svartengren, M., Camner, P., 2002. Particle clearance in human bronchial airways: Comparison of stochastic model predictions with experimental data. Ann. Occ. Hyg. 46(Suppl.), 329-333.
33. Weibel, E.R., 1963. Morphometry of the Human Lung. Academic Press, New York.
34. Wolff, R.K., 1989. Mucociliary function. In: Parent, R.A. (Ed.), Comparative Biology of the Normal Lung. CRC Press, New York, pp. 659-680.
35. Yeates, D.B., Gerrity, T.R., Garrard, C.S., 1982. Characteristics of tracheobronchial deposition and clearance in man. Ann. Occ. Hyg. 26, 245-257.
36. Yeh, H., Schum, G.M., 1980. Models of Human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42, 461-80.
37. Yu, C.P., Hu, J.P., Yen, B.M., Spektor, D.M., Lippmann, M., 1986. Models for mucociliary particle clearance in lung airways. In: Lee, S.D., Schneider, T., Grant, L.D., Verkerk, P.J. (Eds.), Aerosols: Research, Risk Assessment and Control Strategies, MI, Lewis, Chelsea, pp. 569-578.