Th17 cells, a novel proinflammatory effector CD4 T cell population;Les cellules Th17 Une nouvelle population de cellules T CD4 effectrices pro-inflammatoires

Medecine/Sciences

Volumn 24, Issue 11, 2008, Pages 972-976

  Leung Theung Long, Stéphane ^a   Guerder, Sylvie ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; INTERLEUKIN 22;

AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; EFFECTOR CELL; EPITHELIUM; EXTRACELLULAR SPACE; HUMAN; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; NEUTROPHIL; PATHOPHYSIOLOGY; PROTEIN FUNCTION; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

EID: 57149091150     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20082411972     Document Type: Review

References (29)

1. Bettelli E, Sullivan B, Szabo SJ, et al. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med 2004 ; 200 : 79-87.
2. Ferber IA, Brocke S, Taylor-Edwards C, et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996 ; 156 : 5-7.
3. Chitnis T, Najafian N, Benou C, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 2001 ; 108 : 739-47.
4. Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000 ; 13 : 715-25.
5. Cua DJ, Sherlock J, Chen Y, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003 ; 421 : 744-8.
6. Aggarwal S, Ghilardi N, Xie MH, et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003 ; 278 : 1910-4.
7. Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006 ; 441 : 235-8.
8. McGeachy MJ, Bak-Jensen KS, Chen Y, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol 2007 ; 8 : 1390-7.
9. Batten M, Li J, Yi S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006 ; 7 : 929-36.
10. Kleinschek MA, Owyang AM, Joyce-Shaikh B, et al. IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 2007 ; 204 : 161-70.
11. Laurence A, Tato CM, Davidson TS, et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 2007 ; 26 : 371-81.
12. + T helper cells. Cell 2006 ; 126 : 1121-33.
13. Harris TJ, Grosso JF, Yen HR, et al. Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol 2007 ; 179 : 4313-7.
14. Brustle A, Heink S, Huber M, et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 2007 ; 8 : 958-66.
15. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007 ; 8 : 942-9.
16. Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007 ; 8 : 950-7.
17. Van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, et al. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 2007 ; 27 : 660-9.
18. Yang L, Anderson DE, Baecher-Allan C, et al. IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature 2008 ; 454 : 350-2.
19. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008 ; 9 : 641-9.
20. Volpe E, Servant N, Zollinger R, et al. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008 ; 9 : 650-7.
21. Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity 2004 ; 21 : 467-76.
22. Chakravarti A, Allaeys I, Poubelle PE. Neutrophile et immunité : Est-ce inné ou acquis ? Med Sci (Paris) 2007 ; 23 : 862-7.
23. Happel KI, Dubin PJ, Zheng M, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005 ; 202 : 761-9.
24. Huang W, Na L, Fidel PL, Schwarzenberger P. Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice. J Infect Dis 2004 ; 190 : 624-31.
25. Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 2006 ; 18 : 349-56.
26. Schnyder-Candrian S, Togbe D, Couillin I, et al. Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med 2006 ; 203 : 2715-25.
27. Anjuère F, Czerkinsky C. Immunité muqueuse et vaccination. Med Sci (Paris) 2007 ; 23 : 371-8.
28. Michel ML, Keller AC, Paget C, et al. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. J Exp Med 2007 ; 204 : 995-1001.
29. Hill JA, Feuerer M, Tash K, et al. Foxp3 transcription-factor- dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007 ; 27 : 786-800.