메뉴 건너뛰기




Volumn 28, Issue 4, 2008, Pages 553-567

Pharmacogenomics of Tamoxifen and Irinotecan Therapies

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; 7 ETHYL 10 HYDROXYCAMPTOTHECIN GLUCURONIDE; ANTHRACYCLINE; ANTIDEPRESSANT AGENT; CYTOCHROME P450 2D6; DRUG METABOLITE; ENDOXIFEN; ENZYME INHIBITOR; ESTROGEN RECEPTOR; FLUOROURACIL; FLUOXETINE; FOLINIC ACID; GLUCURONOSYLTRANSFERASE 1A1; IRINOTECAN; NORTAMOXIFEN; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; TAMOXIFEN; UNCLASSIFIED DRUG;

EID: 57149085290     PISSN: 02722712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cll.2008.05.004     Document Type: Review
Times cited : (8)

References (69)
  • 2
    • 57149093749 scopus 로고    scopus 로고
    • Available at:Accessed March 3, 2008
    • US clinical trials registry. http://clinicaltrials.gov/ Available at:Accessed March 3, 2008
    • US clinical trials registry
  • 3
    • 39049143026 scopus 로고    scopus 로고
    • An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
    • Wierdl M., Tsurkan L., Hyatt J.L., et al. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11. Cancer Gene Ther 15 3 (2008) 183-192
    • (2008) Cancer Gene Ther , vol.15 , Issue.3 , pp. 183-192
    • Wierdl, M.1    Tsurkan, L.2    Hyatt, J.L.3
  • 4
    • 0036207927 scopus 로고    scopus 로고
    • Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes
    • Hanioka N., Ozawa S., Jinno H., et al. Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. Drug Metab Dispos 30 4 (2002) 391-396
    • (2002) Drug Metab Dispos , vol.30 , Issue.4 , pp. 391-396
    • Hanioka, N.1    Ozawa, S.2    Jinno, H.3
  • 5
    • 2342558617 scopus 로고    scopus 로고
    • Irinotecan pharmacogenetics: is it time to intervene?
    • McLeod H.L., and Watters J.W. Irinotecan pharmacogenetics: is it time to intervene?. J Clin Oncol 22 8 (2004) 1356-1359
    • (2004) J Clin Oncol , vol.22 , Issue.8 , pp. 1356-1359
    • McLeod, H.L.1    Watters, J.W.2
  • 6
    • 33845759934 scopus 로고    scopus 로고
    • *28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity
    • *28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity. J Clin Pharmacol 47 1 (2007) 78-86
    • (2007) J Clin Pharmacol , vol.47 , Issue.1 , pp. 78-86
    • Ramchandani, R.P.1    Wang, Y.2    Booth, B.P.3
  • 7
    • 34347371390 scopus 로고    scopus 로고
    • Insights, challenges, and future directions in irinogenetics
    • Kim T.W., and Innocenti F. Insights, challenges, and future directions in irinogenetics. Ther Drug Monit 29 3 (2007) 265-270
    • (2007) Ther Drug Monit , vol.29 , Issue.3 , pp. 265-270
    • Kim, T.W.1    Innocenti, F.2
  • 8
    • 33645120407 scopus 로고    scopus 로고
    • Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer
    • Nagar S., and Remmel R.P. Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. Oncogene 25 11 (2006) 1659-1672
    • (2006) Oncogene , vol.25 , Issue.11 , pp. 1659-1672
    • Nagar, S.1    Remmel, R.P.2
  • 9
    • 2342459714 scopus 로고    scopus 로고
    • Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan
    • Innocenti F., Undevia S.D., Iyer L., et al. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan. J Clin Oncol 22 8 (2004) 1382-1388
    • (2004) J Clin Oncol , vol.22 , Issue.8 , pp. 1382-1388
    • Innocenti, F.1    Undevia, S.D.2    Iyer, L.3
  • 10
    • 33845893608 scopus 로고    scopus 로고
    • Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping
    • Innocenti F., and Ratain M.J. Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping. Pharmacogenomics 7 8 (2006) 1211-1221
    • (2006) Pharmacogenomics , vol.7 , Issue.8 , pp. 1211-1221
    • Innocenti, F.1    Ratain, M.J.2
  • 11
    • 33750583902 scopus 로고    scopus 로고
    • Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: practical pharmacogenomics arrives in cancer therapy
    • O'Dwyer P.J., and Catalano R.B. Uridine diphosphate glucuronosyltransferase (UGT) 1A1 and irinotecan: practical pharmacogenomics arrives in cancer therapy. J Clin Oncol 24 28 (2006) 4534-4538
    • (2006) J Clin Oncol , vol.24 , Issue.28 , pp. 4534-4538
    • O'Dwyer, P.J.1    Catalano, R.B.2
  • 12
    • 33751103939 scopus 로고    scopus 로고
    • Adding pharmacogenetics information to drug labels: lessons learned
    • Haga S.B., Thummel K.E., and Burke W. Adding pharmacogenetics information to drug labels: lessons learned. Pharmacogenet Genomics 16 12 (2006) 847-854
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.12 , pp. 847-854
    • Haga, S.B.1    Thummel, K.E.2    Burke, W.3
  • 13
  • 14
    • 39149141390 scopus 로고    scopus 로고
    • *)6 for irinotecan toxicities in Japanese cancer patients
    • *)6 for irinotecan toxicities in Japanese cancer patients. Cancer Lett 261 2 (2008) 165-171
    • (2008) Cancer Lett , vol.261 , Issue.2 , pp. 165-171
    • Sai, K.1    Saito, Y.2    Sakamoto, H.3
  • 15
    • 0038275905 scopus 로고    scopus 로고
    • Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D
    • Jinno H., Tanaka-Kagawa T., Hanioka N., et al. Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan (CPT-11), by human UGT1A1 variants, G71R, P229Q, and Y486D. Drug Metab Dispos 31 1 (2003) 108-113
    • (2003) Drug Metab Dispos , vol.31 , Issue.1 , pp. 108-113
    • Jinno, H.1    Tanaka-Kagawa, T.2    Hanioka, N.3
  • 16
    • 0036765309 scopus 로고    scopus 로고
    • Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)
    • Gagne J.F., Montminy V., Belanger P., et al. Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38). Mol Pharmacol 62 3 (2002) 608-617
    • (2002) Mol Pharmacol , vol.62 , Issue.3 , pp. 608-617
    • Gagne, J.F.1    Montminy, V.2    Belanger, P.3
  • 17
    • 34548598459 scopus 로고    scopus 로고
    • *28 genotype and irinotecan-induced neutropenia: dose matters
    • *28 genotype and irinotecan-induced neutropenia: dose matters. J Natl Cancer Inst 99 17 (2007) 1290-1295
    • (2007) J Natl Cancer Inst , vol.99 , Issue.17 , pp. 1290-1295
    • Hoskins, J.M.1    Goldberg, R.M.2    Qu, P.3
  • 18
    • 34447285021 scopus 로고    scopus 로고
    • UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan
    • Stewart C.F., Panetta J.C., O'Shaughnessy M.A., et al. UGT1A1 promoter genotype correlates with SN-38 pharmacokinetics, but not severe toxicity in patients receiving low-dose irinotecan. J Clin Oncol 25 18 (2007) 2594-2600
    • (2007) J Clin Oncol , vol.25 , Issue.18 , pp. 2594-2600
    • Stewart, C.F.1    Panetta, J.C.2    O'Shaughnessy, M.A.3
  • 19
    • 35648981948 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group Study
    • Bomgaars L.R., Bernstein M., Krailo M., et al. Phase II trial of irinotecan in children with refractory solid tumors: a Children's Oncology Group Study. J Clin Oncol 25 29 (2007) 4622-4627
    • (2007) J Clin Oncol , vol.25 , Issue.29 , pp. 4622-4627
    • Bomgaars, L.R.1    Bernstein, M.2    Krailo, M.3
  • 20
    • 36348963081 scopus 로고    scopus 로고
    • Combining chemotherapy and targeted therapies in metastatic colorectal cancer
    • Rodriguez J., Zarate R., Bandres E., et al. Combining chemotherapy and targeted therapies in metastatic colorectal cancer. World J Gastroenterol 13 44 (2007) 5867-5876
    • (2007) World J Gastroenterol , vol.13 , Issue.44 , pp. 5867-5876
    • Rodriguez, J.1    Zarate, R.2    Bandres, E.3
  • 21
    • 0345734082 scopus 로고    scopus 로고
    • Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives
    • Cummings J., Ethell B.T., Jardine L., et al. Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives. Cancer Res 63 23 (2003) 8443-8450
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8443-8450
    • Cummings, J.1    Ethell, B.T.2    Jardine, L.3
  • 22
    • 33744802935 scopus 로고    scopus 로고
    • Irinogenetics: what is the right star?
    • Innocenti F., Vokes E.E., and Ratain M.J. Irinogenetics: what is the right star?. J Clin Oncol 24 15 (2006) 2221-2224
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2221-2224
    • Innocenti, F.1    Vokes, E.E.2    Ratain, M.J.3
  • 23
    • 0141519502 scopus 로고    scopus 로고
    • Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs
    • Villeneuve L., Girard H., Fortier L.C., et al. Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs. J Pharmacol Exp Ther 307 1 (2003) 117-128
    • (2003) J Pharmacol Exp Ther , vol.307 , Issue.1 , pp. 117-128
    • Villeneuve, L.1    Girard, H.2    Fortier, L.C.3
  • 24
    • 3242769758 scopus 로고    scopus 로고
    • Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38
    • Paoluzzi L., Singh A.S., Price D.K., et al. Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38. J Clin Pharmacol 44 8 (2004) 854-860
    • (2004) J Clin Pharmacol , vol.44 , Issue.8 , pp. 854-860
    • Paoluzzi, L.1    Singh, A.S.2    Price, D.K.3
  • 25
    • 0036313887 scopus 로고    scopus 로고
    • Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients
    • Ando M., Ando Y., Sekido Y., et al. Genetic polymorphisms of the UDP-glucuronosyltransferase 1A7 gene and irinotecan toxicity in Japanese cancer patients. Jpn J Cancer Res 93 5 (2002) 591-597
    • (2002) Jpn J Cancer Res , vol.93 , Issue.5 , pp. 591-597
    • Ando, M.1    Ando, Y.2    Sekido, Y.3
  • 26
    • 12944329893 scopus 로고    scopus 로고
    • UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan
    • Carlini L.E., Meropol N.J., Bever J., et al. UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res 11 3 (2005) 1226-1236
    • (2005) Clin Cancer Res , vol.11 , Issue.3 , pp. 1226-1236
    • Carlini, L.E.1    Meropol, N.J.2    Bever, J.3
  • 27
    • 34250665419 scopus 로고    scopus 로고
    • *6 is associated with reduced activity for SN-38 in Japanese patients with cancer
    • *6 is associated with reduced activity for SN-38 in Japanese patients with cancer. Cancer Chemother Pharmacol 60 4 (2007) 515-522
    • (2007) Cancer Chemother Pharmacol , vol.60 , Issue.4 , pp. 515-522
    • Fujita, K.1    Ando, Y.2    Nagashima, F.3
  • 28
    • 34249727317 scopus 로고    scopus 로고
    • Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism
    • Baudhuin L.M., Highsmith W.E., Skierka J., et al. Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism. Clin Biochem 40 9-10 (2007) 710-717
    • (2007) Clin Biochem , vol.40 , Issue.9-10 , pp. 710-717
    • Baudhuin, L.M.1    Highsmith, W.E.2    Skierka, J.3
  • 29
    • 34247582780 scopus 로고    scopus 로고
    • Validation of rapid polymerase chain reaction-based detection of all length polymorphisms in the UGT 1A1 gene promoter
    • Huang C.K., Dulau A., Su-Rick C.J., et al. Validation of rapid polymerase chain reaction-based detection of all length polymorphisms in the UGT 1A1 gene promoter. Diagn Mol Pathol 16 1 (2007) 50-53
    • (2007) Diagn Mol Pathol , vol.16 , Issue.1 , pp. 50-53
    • Huang, C.K.1    Dulau, A.2    Su-Rick, C.J.3
  • 30
    • 33748925080 scopus 로고    scopus 로고
    • Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer
    • Araki K., Fujita K., Ando Y., et al. Pharmacogenetic impact of polymorphisms in the coding region of the UGT1A1 gene on SN-38 glucuronidation in Japanese patients with cancer. Cancer Sci 97 11 (2006) 1255-1259
    • (2006) Cancer Sci , vol.97 , Issue.11 , pp. 1255-1259
    • Araki, K.1    Fujita, K.2    Ando, Y.3
  • 31
    • 39749156447 scopus 로고    scopus 로고
    • Irinophore C: a liposome formulation of irinotecan with substantially improved therapeutic efficacy against a panel of human xenograft tumors
    • Ramsay E.C., Anantha M., Zastre J., et al. Irinophore C: a liposome formulation of irinotecan with substantially improved therapeutic efficacy against a panel of human xenograft tumors. Clin Cancer Res 14 4 (2008) 1208-1217
    • (2008) Clin Cancer Res , vol.14 , Issue.4 , pp. 1208-1217
    • Ramsay, E.C.1    Anantha, M.2    Zastre, J.3
  • 32
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study
    • Fisher B., Costantino J.P., Wickerham D.L., et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90 18 (1998) 1371-1388
    • (1998) J Natl Cancer Inst , vol.90 , Issue.18 , pp. 1371-1388
    • Fisher, B.1    Costantino, J.P.2    Wickerham, D.L.3
  • 33
    • 33645459056 scopus 로고    scopus 로고
    • Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: International Breast Cancer Study Group Trial 13-93
    • Colleoni M., Gelber S., Goldhirsch A., et al. Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: International Breast Cancer Study Group Trial 13-93. J Clin Oncol 24 9 (2006) 1332-1341
    • (2006) J Clin Oncol , vol.24 , Issue.9 , pp. 1332-1341
    • Colleoni, M.1    Gelber, S.2    Goldhirsch, A.3
  • 34
    • 19344364880 scopus 로고    scopus 로고
    • Early Breast Cancer Trialists Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Early Breast Cancer Trialists Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365 9472 (2005) 1687-1717
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 35
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne C.K. Tamoxifen in the treatment of breast cancer. N Engl J Med 339 22 (1998) 1609-1618
    • (1998) N Engl J Med , vol.339 , Issue.22 , pp. 1609-1618
    • Osborne, C.K.1
  • 36
    • 0017665570 scopus 로고
    • A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
    • Jordan V.C., Collins M.M., Rowsby L., et al. A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol 75 2 (1977) 305-316
    • (1977) J Endocrinol , vol.75 , Issue.2 , pp. 305-316
    • Jordan, V.C.1    Collins, M.M.2    Rowsby, L.3
  • 37
    • 0024584001 scopus 로고
    • Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment
    • Lien E.A., Solheim E., Lea O.A., et al. Distribution of 4-hydroxy-N-desmethyltamoxifen and other tamoxifen metabolites in human biological fluids during tamoxifen treatment. Cancer Res 49 8 (1989) 2175-2183
    • (1989) Cancer Res , vol.49 , Issue.8 , pp. 2175-2183
    • Lien, E.A.1    Solheim, E.2    Lea, O.A.3
  • 38
    • 0036325773 scopus 로고    scopus 로고
    • Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4′-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen
    • Crewe H.K., Notley L.M., Wunsch R.M., et al. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4′-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos 30 8 (2000) 869-874
    • (2000) Drug Metab Dispos , vol.30 , Issue.8 , pp. 869-874
    • Crewe, H.K.1    Notley, L.M.2    Wunsch, R.M.3
  • 39
    • 0037976797 scopus 로고    scopus 로고
    • Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial
    • Stearns V., Beebe K.L., Iyengar M., et al. Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial. JAMA 289 21 (2003) 2827-2834
    • (2003) JAMA , vol.289 , Issue.21 , pp. 2827-2834
    • Stearns, V.1    Beebe, K.L.2    Iyengar, M.3
  • 40
    • 4243063941 scopus 로고    scopus 로고
    • Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6
    • Desta Z., Ward B.A., Soukhova N.V., et al. Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther 310 3 (2004) 1062-1075
    • (2004) J Pharmacol Exp Ther , vol.310 , Issue.3 , pp. 1062-1075
    • Desta, Z.1    Ward, B.A.2    Soukhova, N.V.3
  • 41
    • 18544389188 scopus 로고    scopus 로고
    • The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver
    • Coller J.K., Krebsfaenger N., Klein K., et al. The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver. Br J Clin Pharmacol 54 2 (2002) 157-167
    • (2002) Br J Clin Pharmacol , vol.54 , Issue.2 , pp. 157-167
    • Coller, J.K.1    Krebsfaenger, N.2    Klein, K.3
  • 42
    • 0019411776 scopus 로고
    • Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
    • Borgna J.L., and Rochefort H. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J Biolumin Chemilumin 256 2 (1981) 859-868
    • (1981) J Biolumin Chemilumin , vol.256 , Issue.2 , pp. 859-868
    • Borgna, J.L.1    Rochefort, H.2
  • 43
    • 0020033521 scopus 로고
    • Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen
    • Robertson D.W., Katzenellenbogen J.A., Long D.J., et al. Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen. J Steroid Biochem 16 1 (1982) 1-13
    • (1982) J Steroid Biochem , vol.16 , Issue.1 , pp. 1-13
    • Robertson, D.W.1    Katzenellenbogen, J.A.2    Long, D.J.3
  • 44
    • 0020003085 scopus 로고
    • Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth
    • Coezy E., Borgna J.L., and Rochefort H. Tamoxifen and metabolites in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res 42 1 (1982) 317-323
    • (1982) Cancer Res , vol.42 , Issue.1 , pp. 317-323
    • Coezy, E.1    Borgna, J.L.2    Rochefort, H.3
  • 45
    • 3342932419 scopus 로고    scopus 로고
    • Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen
    • Johnson M.D., Zuo H., Lee K.H., et al. Pharmacological characterization of 4-hydroxy-N-desmethyl tamoxifen, a novel active metabolite of tamoxifen. Breast Cancer Res Treat 85 2 (2004) 151-159
    • (2004) Breast Cancer Res Treat , vol.85 , Issue.2 , pp. 151-159
    • Johnson, M.D.1    Zuo, H.2    Lee, K.H.3
  • 46
    • 17644387537 scopus 로고    scopus 로고
    • Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen
    • Lim Y.C., Desta Z., Flockhart D.A., et al. Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen. Cancer Chemother Pharmacol 55 5 (2005) 471-478
    • (2005) Cancer Chemother Pharmacol , vol.55 , Issue.5 , pp. 471-478
    • Lim, Y.C.1    Desta, Z.2    Flockhart, D.A.3
  • 47
    • 19444376971 scopus 로고    scopus 로고
    • Drug metabolism and variability among patients in drug response
    • Wilkinson G.R. Drug metabolism and variability among patients in drug response. N Engl J Med 352 21 (2005) 2211-2221
    • (2005) N Engl J Med , vol.352 , Issue.21 , pp. 2211-2221
    • Wilkinson, G.R.1
  • 48
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M., Sim S.C., Gomez A., et al. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116 3 (2007) 496-526
    • (2007) Pharmacol Ther , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3
  • 49
    • 19944434201 scopus 로고    scopus 로고
    • CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment
    • Jin Y., Desta Z., Stearns V., et al. CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment. J Natl Cancer Inst 97 1 (2005) 30-39
    • (2005) J Natl Cancer Inst , vol.97 , Issue.1 , pp. 30-39
    • Jin, Y.1    Desta, Z.2    Stearns, V.3
  • 50
    • 33745347897 scopus 로고    scopus 로고
    • Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment
    • Borges S., Desta Z., Li L., et al. Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment. Clin Pharmacol Ther 80 1 (2006) 61-74
    • (2006) Clin Pharmacol Ther , vol.80 , Issue.1 , pp. 61-74
    • Borges, S.1    Desta, Z.2    Li, L.3
  • 51
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • Goetz M.P., Rae J.M., Suman V.J., et al. Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23 36 (2005) 9312-9318
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 52
    • 33747045564 scopus 로고    scopus 로고
    • Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial
    • [author reply: 3709]
    • Bonanni B., Macis D., Maisonneuve P., et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian Tamoxifen Trial. J Clin Oncol 24 22 (2006) 3708-3709 [author reply: 3709]
    • (2006) J Clin Oncol , vol.24 , Issue.22 , pp. 3708-3709
    • Bonanni, B.1    Macis, D.2    Maisonneuve, P.3
  • 53
    • 21344467511 scopus 로고    scopus 로고
    • Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    • Nowell S.A., Ahn J., Rae J.M., et al. Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients. Breast Cancer Res Treat 91 3 (2005) 249-258
    • (2005) Breast Cancer Res Treat , vol.91 , Issue.3 , pp. 249-258
    • Nowell, S.A.1    Ahn, J.2    Rae, J.M.3
  • 54
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • Wegman P., Elingarami S., Carstensen J., et al. Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 9 1 (2007) R7
    • (2007) Breast Cancer Res , vol.9 , Issue.1
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3
  • 55
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • Wegman P., Vainikka L., Stal O., et al. Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 7 3 (2005) R284-R290
    • (2005) Breast Cancer Res , vol.7 , Issue.3
    • Wegman, P.1    Vainikka, L.2    Stal, O.3
  • 56
    • 37549006389 scopus 로고    scopus 로고
    • Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response
    • Goetz M.P., Kamal A., and Ames M.M. Tamoxifen pharmacogenomics: the role of CYP2D6 as a predictor of drug response. Clin Pharmacol Ther 83 1 (2008) 160-166
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.1 , pp. 160-166
    • Goetz, M.P.1    Kamal, A.2    Ames, M.M.3
  • 57
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen
    • Goetz M.P., Knox S.K., Suman V.J., et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen. Breast Cancer Res Treat 101 1 (2007) 113-121
    • (2007) Breast Cancer Res Treat , vol.101 , Issue.1 , pp. 113-121
    • Goetz, M.P.1    Knox, S.K.2    Suman, V.J.3
  • 58
    • 34047124311 scopus 로고    scopus 로고
    • Venlafaxine is superior to clonidine as treatment of hot flashes in breast cancer patients - a double-blind, randomized study
    • Loibl S., Schwedler K., von Minckwitz G., et al. Venlafaxine is superior to clonidine as treatment of hot flashes in breast cancer patients - a double-blind, randomized study. Ann Oncol 18 4 (2007) 689-693
    • (2007) Ann Oncol , vol.18 , Issue.4 , pp. 689-693
    • Loibl, S.1    Schwedler, K.2    von Minckwitz, G.3
  • 59
    • 33845190830 scopus 로고    scopus 로고
    • Genetics examined in tamoxifen's effectiveness: recurrence warning urged for labeling
    • Young D. Genetics examined in tamoxifen's effectiveness: recurrence warning urged for labeling. Am J Health Syst Pharm 63 23 (2006) 2286-2296
    • (2006) Am J Health Syst Pharm , vol.63 , Issue.23 , pp. 2286-2296
    • Young, D.1
  • 60
    • 11444251764 scopus 로고    scopus 로고
    • Results of the ATAC (Arimidex, Tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for breast cancer
    • Howell A., Cuzick J., Baum M., et al. Results of the ATAC (Arimidex, Tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for breast cancer. Lancet 365 9453 (2005) 60-62
    • (2005) Lancet , vol.365 , Issue.9453 , pp. 60-62
    • Howell, A.1    Cuzick, J.2    Baum, M.3
  • 61
    • 34047176388 scopus 로고    scopus 로고
    • Raloxifene and the prevention of breast cancer
    • Bevers T.B. Raloxifene and the prevention of breast cancer. Expert Opin Pharmacother 7 16 (2006) 2301-2307
    • (2006) Expert Opin Pharmacother , vol.7 , Issue.16 , pp. 2301-2307
    • Bevers, T.B.1
  • 62
    • 33745249570 scopus 로고    scopus 로고
    • Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial
    • Vogel V.G., Costantino J.P., Wickerham D.L., et al. Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP study of tamoxifen and raloxifene (STAR) P-2 trial. JAMA 295 23 (2006) 2727-2741
    • (2006) JAMA , vol.295 , Issue.23 , pp. 2727-2741
    • Vogel, V.G.1    Costantino, J.P.2    Wickerham, D.L.3
  • 63
    • 10444221019 scopus 로고    scopus 로고
    • Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients
    • Tucker A.N., Tkaczuk K.A., Lewis L.M., et al. Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett 217 1 (2005) 61-72
    • (2005) Cancer Lett , vol.217 , Issue.1 , pp. 61-72
    • Tucker, A.N.1    Tkaczuk, K.A.2    Lewis, L.M.3
  • 64
    • 0036786382 scopus 로고    scopus 로고
    • Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
    • Koch I., Weil R., Wolbold R., et al. Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Dispos 30 10 (2002) 1108-1114
    • (2002) Drug Metab Dispos , vol.30 , Issue.10 , pp. 1108-1114
    • Koch, I.1    Weil, R.2    Wolbold, R.3
  • 65
    • 0037518214 scopus 로고    scopus 로고
    • Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism
    • Westlind-Johnsson A., Malmebo S., Johansson A., et al. Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism. Drug Metab Dispos 31 6 (2003) 755-761
    • (2003) Drug Metab Dispos , vol.31 , Issue.6 , pp. 755-761
    • Westlind-Johnsson, A.1    Malmebo, S.2    Johansson, A.3
  • 66
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
    • Schroth W., Antoniadou L., Fritz P., et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol 25 33 (2007) 5187-5193
    • (2007) J Clin Oncol , vol.25 , Issue.33 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3
  • 67
    • 0036947726 scopus 로고    scopus 로고
    • 4-Hydroxytamoxifen sulfation metabolism
    • Chen G., Yin S., Maiti S., et al. 4-Hydroxytamoxifen sulfation metabolism. J Biochem Mol Toxicol 16 6 (2002) 279-285
    • (2002) J Biochem Mol Toxicol , vol.16 , Issue.6 , pp. 279-285
    • Chen, G.1    Yin, S.2    Maiti, S.3
  • 68
    • 0037032497 scopus 로고    scopus 로고
    • Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
    • Nowell S., Sweeney C., Winters M., et al. Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy. J Natl Cancer Inst 94 21 (2002) 1635-1640
    • (2002) J Natl Cancer Inst , vol.94 , Issue.21 , pp. 1635-1640
    • Nowell, S.1    Sweeney, C.2    Winters, M.3
  • 69
    • 37849000864 scopus 로고    scopus 로고
    • Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism
    • Gjerde J., Hauglid M., Breilid H., et al. Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol 19 1 (2008) 56-61
    • (2008) Ann Oncol , vol.19 , Issue.1 , pp. 56-61
    • Gjerde, J.1    Hauglid, M.2    Breilid, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.