Obesity and excessive daytime sleepiness in prepubertal children with obstructive sleep apnea

Pediatrics

Volumn 123, Issue 1, 2009, Pages 13-18

  Gozal, David ^a   Kheirandish Gozal, Leila ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Excessive daytime sleepiness; Hypoxia; Obesity; Sleep apnea; Sleep fragmentation

Indexed keywords

AROUSAL; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DAYTIME SOMNOLENCE; FEMALE; FOLLOW UP; HUMAN; MALE; OBESITY; OXYGEN SATURATION; POLYSOMNOGRAPHY; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SLEEP; SLEEP APNEA SYNDROME; SLEEP TIME; SNORING; AGE; COHORT ANALYSIS; COMPARATIVE STUDY; METHODOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; SOMNOLENCE;

AGE FACTORS; CHILD; COHORT STUDIES; DISORDERS OF EXCESSIVE SOMNOLENCE; FEMALE; HUMANS; MALE; OBESITY; POLYSOMNOGRAPHY; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE;

EID: 57149084244     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-0228     Document Type: Article

References (55)

1. Magarey AM, Daniels LA, Boulton TJ. Prevalence of overweight and obesity in Australian children and adolescents: reassessment of 1985 and 1995 data against new standard international definitions. Med J Aust. 2001;174(11):561-564
2. Lobstein T, Baur L, Uauy R; IASO International Obesity TaskForce. Obesity in children and young people: a crisis in public health. Obes Rev. 2004;5(suppl 1):4-104
3. Malecka-Tendera E, Mazur A. Childhood obesity: a pandemic of the twenty-first century. Int J Obes (Lond). 2006;30(suppl 2):S1-S3
4. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002;109(1):45-60
5. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA. 2002;288(14):1728-1732
6. Kaditis AG, Finder J, Alexopoulos EI, et al. Sleep-disordered breathing in 3680 Greek children. Pediatr Pulmonol. 2004;37(6):499-509
7. Blunden S, Lushington K, Lorenzen B, Wong J, Balendran R, Kennedy D. Symptoms of sleep breathing disorders in children are underreported by parents at general practice visits. Sleep Breath. 2003;7(4):167-176
8. Castronovo V, Zucconi M, Nosetti L, et al. Prevalence of habitual snoring and sleep-disordered breathing in preschool-aged children in an Italian community. J Pediatr. 2003;142(4):377-382
9. O'Brien LM, Holbrook CR, Mervis CB, et al. Sleep and neu- robehavioral characteristics of 5- to 7-year-old children with parentally reported symptoms of attention-deficit/hyperactivity disorder. Pediatrics. 2003;111(3):554-563
10. Montgomery-Downs HE, O'Brien LM, Holbrook CR, Gozal D. Snoring and sleep-disordered breathing in young children: subjective and objective correlates. Sleep. 2004;27(1):87-94
11. Eitner S, Urschitz MS, Guenther A, et al. Sleep problems and daytime somnolence in a German population-based sample of snoring school-aged children. J Sleep Res. 2007;16(1):96-101
12. Arens R, Marcus CL. Pathophysiology of upper airway obstruction: a developmental perspective. Sleep. 2004;27(5):997-1019
13. Bell LM, Byrne S, Thompson A, et al. Increasing body mass index z score is continuously associated with complications of overweight in children, even in the healthy weight range. J Clin Endocrinol Metab. 2007;92(2):517-522
14. Ievers-Landis CE, Redline S. Pediatric sleep apnea: implications of the epidemic of childhood overweight. Am J Respir Crit Care Med. 2007;175(5):436-441
15. Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep-disordered breathing and the metabolic syndrome in overweight and obese children and adolescents. J Pediatr. 2007;150(6):608-612
16. Tauman R, Gozal D. Obesity and obstructive sleep apnea in children. Paediatr Respir Rev. 2006;7(4):247-259
17. Verhulst SL, Schrauwen N, Haentjens D, et al. Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution. Arch Dis Child. 2007;92(3):205-208
18. Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children: associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 1999;159(5):1527-1532
19. Carroll JL, McColley SA, Marcus CL, Curtis S, Loughlin GM. Inability of clinical history to distinguish primary snoring from obstructive sleep apnea syndrome in children. Chest. 1995; 108(3):610-618
20. Chervin RD, Weatherly RA, Ruzicka DL, et al. Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical care. Sleep. 2006; 29(4):495-503
21. Gozal D, Wang M, Pope DW Jr. Objective sleepiness measures in pediatric obstructive sleep apnea. Pediatrics. 2001;108(3):693-697
22. Melendres MC, Lutz JM, Rubin ED, Marcus CL. Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing. Pediatrics. 2004;114(3):768-775
23. Montgomery-Downs HE, O'Brien LM, Gulliver TE, Gozal D. Polysomnographic characteristics in normal preschool and early school-age children. Pediatrics. 2006;117(3):741-753
24. Rechtschaffen A, Kales A. A Manual of Standardized Terminology, Techniques and Scoring Systems for Sleep Stages of Human Subjects. Washington, DC: National Institutes of Health; 1968. Publication 204
25. American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med. 1996;153(2):866-878
26. American Sleep Disorders Association, Sleep Disorders Atlas Task Force. EEG arousals: scoring rules and examples. Sleep. 1992;15(2):173-184
27. Mograss MA, Ducharme FM, Brouillette RT. Movement/arousals: description, classification, and relationship to sleep apnea in children. Am J Respir Crit Care Med. 1994;150(6):1690 -1696
28. Tauman R, O'Brien LM, Holbrook CR, Gozal D. Sleep pressure score: a new index of sleep disruption in snoring children. Sleep. 2004;27(2):274-278
29. O'Brien LM, Tauman R, Gozal D. Sleep pressure correlates of cognitive and behavioral morbidity in snoring children. Sleep. 2004;27(2):279-282
30. Littner MR, Kushida C, Wise M, et al. Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep. 2005;28(1):113-121
31. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data. 2000;(314):1-27
32. Dayyat E, Kheirandish-Gozal L, Gozal D. Childhood OSA: one or two distinct disease entities? Clin Sleep Med. 2007;2(3):433-444
33. Capdevila OS, Kheirandish-Gozal L, Dayyat E, Gozal D. Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc. 2008;5(2):274-282
34. Mitchell RB, Kelly J. Outcome of adenotonsillectomy for obstructive sleep apnea in obese and normal-weight children. Otolaryngol Head Neck Surg. 2007;137(1):43-48
35. Tauman R, Gulliver TE, Krishna J, et al. Persistence of obstructive sleep apnea syndrome in children after adenotonsillectomy. J Pediatr. 2006;149(6):803-808
36. Chervin RD, Burns JW, Ruzicka DL. Electroencephalographic changes during respiratory cycles predict sleepiness in sleep apnea. Am J Respir Crit Care Med. 2005;171(6):652-658
37. Kapás L, Krueger JM. Tumor necrosis factor-β induces sleep, fever, and anorexia. Am J Physiol. 1992;263(3):R703-R707
38. Takahashi S, Tooley DD, Kapás L, Fang J, Seyer JM, Krueger JM. Inhibition of tumor necrosis factor in the brain suppresses rabbit sleep. Pflugers Arch. 1995;431(2):155-160
39. El-Sheikh M, Buckhalt JA, Granger DA, Erath SA, Acebo C. The association between children's sleep disruption and salivary interleukin-6. J Sleep Res. 2007;16(2):188-197
40. Yasuda T, Yoshida H, Garcia-Garcia F, Kay D, Krueger JM. Interleukin-1 β has a role in cerebral cortical state-dependent electroencephalographic slow-wave activity. Sleep. 2005;28(2):177-184
41. Hogan D, Morrow JD, Smith EM, Opp MR. Interleukin-6 alters sleep of rats. J Neuroimmunol. 2003;137(1-2):59-66
42. Barceló A,delaPeña M, Barbé F, Pierola J, Bosch M, Agustí AG. Prostaglandin D synthase ( β trace) levels in sleep apnea patients with and without sleepiness. Sleep Med. 2007;8(5): 509-511
43. Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, Chrousos GP. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-α antagonist. J Clin Endocrinol Metab. 2004;89(9):4409-4413
44. Vgontzas AN, Bixler EO, Chrousos GP. Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance. JIntern Med. 2003;254(1):32-44
45. Vgontzas AN, Bixler EO, Chrousos GP. Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann N Y Acad Sci. 2006;1083:329-344
46. Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A. Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. J Clin Endocrinol Metab. 2005;90(8):4510 -4515
47. Körner A, Kratzsch J, Gausche R, Schaab M, Erbs S, Kiess W. New predictors of the metabolic syndrome in children: role of adipocytokines. Pediatr Res. 2007;61(6):640-645
48. Williams A, Scharf SM. Obstructive sleep apnea, cardiovascular disease, and inflammation: is NF-κB the key? Sleep Breath. 2007;11(2):69-76
49. Kheirandish-Gozal L, Capdevila OS, Tauman R, Gozal D. Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy. J Clin Sleep Med. 2006;2(3):301-304
50. Tauman R, O'Brien LM, Gozal D. Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing. Sleep Breath. 2007;11(2):77-84
51. Tauman R, Ivanenko A, O'Brien LM, Gozal D. Plasma C-reactive protein levels among children with sleep-disordered breathing. Pediatrics. 2004;113(6). Available at: www.pediatrics.org/cgi/content/full/113/6/e564
52. Gozal D, Serpero LD, Sans Capdevila O, Kheirandish-Gozal L. Systemic inflammation in non-obese children with obstructive sleep apnea. Sleep Med. 2008;9(3):254-259
53. Khalyfa A, Capdevila OS, Buazza MO, Serpero LD, Kheiran- dish-GozalL, Gozal D. Genome-wide gene expression profiling in children with non-obese obstructive sleep apnea. Sleep Med. 2008; In press
54. Vgontzas AN, Bixler EO, Tan TL, Kantner D, Martin LF, Kales A. Obesity without sleep apnea is associated with daytime sleepiness. Arch Intern Med. 1998;158(12):1333-1337
55. Snow A, Gozal E, Malhotra A, et al. Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms. Pediatrics. 2002; 110(6). Available at: www.pediatrics.org/cgi/content/full/110/6/e74