Plasma levels of nitrite/nitrate and inflammation markers in elderly individuals

Bratislava Medical Journal

Volumn 109, Issue 7, 2008, Pages 289-292

  Alusik, Stefan ^a   Jedlickova, V ^a   Paluch, Z ^a   Zecova, S ^a  

^a IPVZ   (Czech Republic)

Author keywords

Inflammation; Nitrate; Nitric oxide; Nitrite; Old age

Indexed keywords

AUTACOID; C REACTIVE PROTEIN; NITRATE; NITRITE; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BLOOD; FEMALE; HUMAN; INFLAMMATION; MALE;

AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; FEMALE; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; NITRATES; NITRITES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57049177667     PISSN: 00069248     EISSN: 13360345     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142.
2. Benz D, Cadet P, Mantione K, Zhu W, Stefano G. Tonal nitric oxide and health - a free radical and scavenger of free radicals. Med Sci Monit 2002; 8: RA1-RA4.
3. Ellis G, Adatia I, Yazdanpanah M, Makela SK. Nitrite and nitrate analyses: a clinical perspective. Clin Biochem 1998; 31: 195-220.
4. Tsikas D. Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Rad Res 2005; 39: 797-815.
5. Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Godecke A, Schrader J, Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 2003; 35: 790-796.
6. Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 2001; 98: 12814-12819.
7. Dejam A, Hunter CJ, Schechter AN, Gladwin MT. Emerging role of nitrite in human biology. Blood Cells Mol Dis 2004; 32: 423-429.
8. Huang PL. Endothelial nitric oxide synthase and endothelial dysfunction. Curr Hypertens Reports 2003; 5: 473-480.
9. Miyazachi H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, Imaizumi T. Endogeous nitric oxide synthase inhibitor: a novel marker of atherosclerosis. Circulation 1999; 99: 1141-1146.
10. Bruunsgaard H. Effect of tumor necrosis alpha and interleukin-6 in elderly populations. Eur Cytokine Netw 2002; 13: 389-391.
11. Lyons D, Roy S, Patel M, Benjamin J, Swift CG. Impaired nitric oxide-mediated vasodilatation and total body nitric oxide production in healthy old age. Clin Sci 1997; 93: 519-525.
12. Toprakci M, Ozmen D, Mutaf I, Turgan N, Parildar Z, Habif S, Guner I, Bayindir O. Age-associated changes in nitric oxide metabolites nitrite and nitrate. Int J Clin Lab Res 2000; 30: 83-85.
13. Massimo CD, Scarpelli P, Lorenzo ND, Caimi G, Orio FD, Ciancarelli MGT. Impaired plasma nitric oxide availability and extracellular superoxide dismutase activity in healthy humans with advancing age. Life Sci 2006; 78: 1163-1167.
14. Kawakatsu M, Ishihara T, Kani K, Nagakawa A, Hiura M, Hazui H, Okabe T, Hoshiga M, Waku S, Iida N, Hanafusa T. Plasma nitrite/nitrate concentration in healthy population and patients with diabetes mellitus - relationship with gender, aging and diabetic complications. Bull Osaka Med Coll 2002; 48: 1-6.
15. Watanabe T, Akishita M, Toba K, Kozaki K, Eto M, Sugimoto N, Kiuchi T, Hashimoto M, Shirakawa W, Ouchi Y. Influence of sex and age on serum nitrite/nitrate concentration in healthy subjects. Clin Chim Acta 2000; 301: 169-179.
16. Brigden ML. Clinical utility of the erythrocyte sedimentation rate. Am Fam Phys 1999; 60: 1443-1450.
17. Jedlièková V, Paluch Z, Alu?ík ?.Determination of nitrate and nitrite by high-performance liquid chromatography in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 780: 193-197.
18. Hoffmann J, Haendeler J, Aicher A, Rossing L, Vasa M, Zeiher AM, Dimmeler S. Aging enhances the sensitivity of endothelial cells towards apoptotic stimuli: important role of nitric oxide. Circulat Res 2001; 89: 709-715.
19. Kleinbongard P, Dejam A, Lauer T, Rassaf T, Schindler A, Picker O, Scheeren T, Godecke A, Schrader J, Schulz R, Heusch G, Schaub GA, Bryan NS, Feelisch M, Kelm M. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radical Biol Med 2003; 35: 790-796.
20. Rhodes PM, Leone AM, Francis PL, Struthers AD, Moncada S. The L-arginine: nitric oxide pathway is the major source of plasma nitrite in fasted humans. Biochem Biophys Res Commun 1995; 205: 590-596.
21. Jobgen WS, Jobgen SC, Li H, Meininger CJ, WU G. Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci 2007; 851: 71-82.
22. Alu?ík ?, Paluch Z, Jedlèková V. The influence of long-term hormonal contraception and smoking on plasma concentrations of nitrites and nitrates. Med Sci Monit 2005; 11: BR61-BR64.
23. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1999; 1411: 273-289.
24. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000; 908: 244-254.
25. Prio TK, Bruunsgaard H, Roge B, Pedersen BK. Asymptomatic bacteriuria in elderly humans is associated with increased levels of circulating TNF receptors and elevated numbers of neutrophils. Exp Gerontol 2002; 37: 693-699.
26. Zhou JF, Cai D, Zhu YG, Yang JL, Peng CH, Yu YH. A study on relationship of nitric oxide, oxidation, peroxidation, lipoperoxidation with chronic cholecystitis. World J Gastroenterol 2000; 6: 501-507.
27. Thomas D. The relationship between functional status and inflammatory disease in older adults. J Gerontol A Biol Sci Med Sci 2003; 58: 995-998.
28. Armstrong ME, Alexander HD, Ritchie JL, McMilan SA, Rea IM. Age-related alterations in basal expression and in vitro, tumor necrosis alpha mediated, upregulation of CD11b. Gerontology 2001; 47: 180-185.
29. Bruunsgaard H, Andersen-Ranberg K, Jeune B, Pedersen AN, Skinhoj P, Pedersen BK. A high plasma concentration of TNF-(alpha) is associated with dementia in centenarias. J Gerontol A Biol Sci Med Sci 1999; 54: M357-364.
30. Krabbe KS, Pedersen M, Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004; 39: 687-699.
31. Knipp BS, Peterson DA, Rajagopalan S, Kehrer C, Ford JW, D Álecy LG, Whitesall SE, Eagleton MJ, Wakefield TW, Henke PK, Jacobs LA, Greenfield LJ, Stanley JC, Upchurch GR Jr. Impaired vasoreactivity despite an increase in plasma nitrite in patients with abdominal aortic aneurysms. J Vasc Surg 2002; 35: 363-367.
32. Mackenzie IM, Ekangaki A, Young JD, Garrard CS. Effect of renal function on serum nitrogen oxide concentration. Clin Chem 1996; 42: 440-444.