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Volumn 121, Issue 1, 2009, Pages 29-37

Vaccination with a novel recombinant Leishmania antigen plus MPL provides partial protection against L. donovani challenge in experimental model of visceral leishmaniasis

Author keywords

Adjuvant; Immunoprophylaxis; Leishmania donovani

Indexed keywords

COMPLEMENTARY DNA; FREUND ADJUVANT; GAMMA INTERFERON; LIPID A DERIVATIVE; MONOPHOSPHORYL A; RECOMBINANT ANTIGEN; RECOMBINANT PROTEIN RA6; RECOMBINANT PROTEINS RF14; UNCLASSIFIED DRUG;

EID: 57049173899     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2008.09.019     Document Type: Article
Times cited : (18)

References (54)
  • 1
    • 0030976397 scopus 로고    scopus 로고
    • Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes
    • Afrin F., and Ali N. Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes. Infection and Immunity 65 (1997) 2371-2377
    • (1997) Infection and Immunity , vol.65 , pp. 2371-2377
    • Afrin, F.1    Ali, N.2
  • 2
    • 33646404904 scopus 로고    scopus 로고
    • Elevated levels of interferon-γ, interleukin-10, and interleukin-6 during active disease in Indian kala azar
    • Ansari N.A., Saluja S., and Salotra P. Elevated levels of interferon-γ, interleukin-10, and interleukin-6 during active disease in Indian kala azar. Clinical Immunology 119 (2006) 339-345
    • (2006) Clinical Immunology , vol.119 , pp. 339-345
    • Ansari, N.A.1    Saluja, S.2    Salotra, P.3
  • 3
    • 13844281637 scopus 로고    scopus 로고
    • Leishmania donovani: identification of novel vaccine candidates using human reactive sera and cell lines
    • Arora S.K., Pal N.S., and Mujtaba S. Leishmania donovani: identification of novel vaccine candidates using human reactive sera and cell lines. Experimental Parasitology 109 (2005) 163-170
    • (2005) Experimental Parasitology , vol.109 , pp. 163-170
    • Arora, S.K.1    Pal, N.S.2    Mujtaba, S.3
  • 4
    • 0025981714 scopus 로고
    • Use of in vitro method to assess different brands of anti-leishmanial drugs
    • Arora S.K., Sinha R., and Sehgal S. Use of in vitro method to assess different brands of anti-leishmanial drugs. Medical Microbiology and Immunology 180 (1991) 21-27
    • (1991) Medical Microbiology and Immunology , vol.180 , pp. 21-27
    • Arora, S.K.1    Sinha, R.2    Sehgal, S.3
  • 5
    • 0002356517 scopus 로고
    • Measurement of neutrophil function: phagocytosis, degranulation, the respiratory burst and bacterial killing
    • Methods in Hematology. Clinc M.J. (Ed), Churchill Livingstone Inc., New York
    • Babior B.M., and Cohen H.J. Measurement of neutrophil function: phagocytosis, degranulation, the respiratory burst and bacterial killing. In: Clinc M.J. (Ed). Methods in Hematology. Leukocyte Function vol. 3 (1981), Churchill Livingstone Inc., New York 17-18
    • (1981) Leukocyte Function , vol.3 , pp. 17-18
    • Babior, B.M.1    Cohen, H.J.2
  • 6
    • 18944378937 scopus 로고    scopus 로고
    • Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis
    • Basu R., Bhaumik S., Basu J.M., Naskar K., De T., and Roy S. Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis. Journal of Immunology 174 (2005) 7160-7171
    • (2005) Journal of Immunology , vol.174 , pp. 7160-7171
    • Basu, R.1    Bhaumik, S.2    Basu, J.M.3    Naskar, K.4    De, T.5    Roy, S.6
  • 7
    • 0035118075 scopus 로고    scopus 로고
    • Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events
    • Bhattacharya S., Ghosh S., Jhonson P.L., Bhattacharya S.K., and Majumdar S. Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infection and Immunity 69 (2001) 1499-1507
    • (2001) Infection and Immunity , vol.69 , pp. 1499-1507
    • Bhattacharya, S.1    Ghosh, S.2    Jhonson, P.L.3    Bhattacharya, S.K.4    Majumdar, S.5
  • 8
    • 0026781801 scopus 로고
    • Establishment of stable, cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major
    • Bretcher P.A., Wei G., Menon J.N., and Bielefeldt-Ohmann H. Establishment of stable, cell-mediated immunity that makes 'susceptible' mice resistant to Leishmania major. Science 257 (1992) 539-542
    • (1992) Science , vol.257 , pp. 539-542
    • Bretcher, P.A.1    Wei, G.2    Menon, J.N.3    Bielefeldt-Ohmann, H.4
  • 9
    • 0027458943 scopus 로고
    • Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis
    • Burns Jr. J.M., Shreffler W.G., Benson D.R., Ghalib H.W., Badaro R., and Reed S.G. Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis. Proceedings of the National Academy of Sciences, USA 90 (1993) 775-779
    • (1993) Proceedings of the National Academy of Sciences, USA , vol.90 , pp. 775-779
    • Burns Jr., J.M.1    Shreffler, W.G.2    Benson, D.R.3    Ghalib, H.W.4    Badaro, R.5    Reed, S.G.6
  • 12
    • 0027469737 scopus 로고
    • Induction of immune response against a short synthetic peptide antigen coupled to small neutral liposomes containing monophosphoryl lipid A
    • Friede M., Muller S., Briand J.P., Van Regenmortel M.H., and Schuber F. Induction of immune response against a short synthetic peptide antigen coupled to small neutral liposomes containing monophosphoryl lipid A. Molecular Immunology 30 (1993) 539-547
    • (1993) Molecular Immunology , vol.30 , pp. 539-547
    • Friede, M.1    Muller, S.2    Briand, J.P.3    Van Regenmortel, M.H.4    Schuber, F.5
  • 13
    • 16244405883 scopus 로고    scopus 로고
    • Immunostimulatory cellular responses of cured Leishmania-infected patients and hamsters against the integral membrane proteins and non-membranous soluble proteins of a recent clinical isolate of Leishmania donovani
    • Garg R., Gupta S.K., Tripathi P., Naik S., Sundar S., and Dube A. Immunostimulatory cellular responses of cured Leishmania-infected patients and hamsters against the integral membrane proteins and non-membranous soluble proteins of a recent clinical isolate of Leishmania donovani. Clinical and Experimental Immunology 140 (2005) 149-156
    • (2005) Clinical and Experimental Immunology , vol.140 , pp. 149-156
    • Garg, R.1    Gupta, S.K.2    Tripathi, P.3    Naik, S.4    Sundar, S.5    Dube, A.6
  • 15
    • 0025648446 scopus 로고
    • Leishmania major amastigotes initiate the l-arginine dependent killing mechanism, in IFN-γ stimulated macrophages by induction of tumor necrosis factor-α
    • Green S.J., Crawford R.M., Hockmeyer J.T., Meltzer M.S., and Nacy C.A. Leishmania major amastigotes initiate the l-arginine dependent killing mechanism, in IFN-γ stimulated macrophages by induction of tumor necrosis factor-α. Journal of Immunology 145 (1990) 4290-4297
    • (1990) Journal of Immunology , vol.145 , pp. 4290-4297
    • Green, S.J.1    Crawford, R.M.2    Hockmeyer, J.T.3    Meltzer, M.S.4    Nacy, C.A.5
  • 16
    • 0027522991 scopus 로고
    • Adjuvants - a balance between toxicity and adjuvanticity
    • Gupta R.K., Relyveld E.H., and Lindblad E.B. Adjuvants - a balance between toxicity and adjuvanticity. Vaccine 11 (1993) 293-306
    • (1993) Vaccine , vol.11 , pp. 293-306
    • Gupta, R.K.1    Relyveld, E.H.2    Lindblad, E.B.3
  • 18
    • 0022558946 scopus 로고
    • Immunological regulation and control of experimental leishmaniasis
    • Howard J.G. Immunological regulation and control of experimental leishmaniasis. International Reviews in Experimental Pathology 28 (1986) 79-116
    • (1986) International Reviews in Experimental Pathology , vol.28 , pp. 79-116
    • Howard, J.G.1
  • 19
    • 0242349620 scopus 로고    scopus 로고
    • The Leishmania infantum acidic ribosomal protein P0 administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB/c mice
    • Iborra S., Soto M., Carrion J., Nieto A., Fernandez E., Alonso C., et al. The Leishmania infantum acidic ribosomal protein P0 administered as a DNA vaccine confers protective immunity to Leishmania major infection in BALB/c mice. Infection and Immunity 71 (2003) 6562-6572
    • (2003) Infection and Immunity , vol.71 , pp. 6562-6572
    • Iborra, S.1    Soto, M.2    Carrion, J.3    Nieto, A.4    Fernandez, E.5    Alonso, C.6
  • 20
    • 33846847777 scopus 로고    scopus 로고
    • Leishmania vaccines: progress and problems
    • Kedzierski L., Zhu Y., and Handman E. Leishmania vaccines: progress and problems. Parasitology 133 (2006) 87-112
    • (2006) Parasitology , vol.133 , pp. 87-112
    • Kedzierski, L.1    Zhu, Y.2    Handman, E.3
  • 21
    • 27944452329 scopus 로고    scopus 로고
    • Intramuscular immunization with p36 (LACK) DNA vaccine induces IFN-gamma production but does not protect BALB/c mice against Leishmania chagasi intravenous challenge
    • Marques-da-Silva E.A., Coelho E.A., Gomes D.C., Vilela M.C., Masioli C.Z., and Tavares C.A. Intramuscular immunization with p36 (LACK) DNA vaccine induces IFN-gamma production but does not protect BALB/c mice against Leishmania chagasi intravenous challenge. Parasitology Research 98 (2005) 67-74
    • (2005) Parasitology Research , vol.98 , pp. 67-74
    • Marques-da-Silva, E.A.1    Coelho, E.A.2    Gomes, D.C.3    Vilela, M.C.4    Masioli, C.Z.5    Tavares, C.A.6
  • 22
    • 0003528088 scopus 로고
    • Immunity: clinical and experimental
    • Peters W., and Killick-Kendrick R. (Eds), Academic Press, London, UK
    • Mauel J., and Behin R. Immunity: clinical and experimental. In: Peters W., and Killick-Kendrick R. (Eds). The Leishmaniasis in Biology and Medicine vol. 2 (1987), Academic Press, London, UK 31-739
    • (1987) The Leishmaniasis in Biology and Medicine , vol.2 , pp. 31-739
    • Mauel, J.1    Behin, R.2
  • 24
    • 0023678603 scopus 로고
    • The dynamics of granuloma formation in experimental visceral leishmaniasis
    • McElrath M.J., Murray H.W., and Cohn Z.A. The dynamics of granuloma formation in experimental visceral leishmaniasis. Journal of Experimental Medicine 167 (1988) 1927-1937
    • (1988) Journal of Experimental Medicine , vol.167 , pp. 1927-1937
    • McElrath, M.J.1    Murray, H.W.2    Cohn, Z.A.3
  • 25
    • 0035253601 scopus 로고    scopus 로고
    • The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    • Melby P.C., Chandrasekar B., Zhao W., and Coe J.E. The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. Journal of Immunology 166 (2001) 1912-1920
    • (2001) Journal of Immunology , vol.166 , pp. 1912-1920
    • Melby, P.C.1    Chandrasekar, B.2    Zhao, W.3    Coe, J.E.4
  • 26
    • 0031948654 scopus 로고    scopus 로고
    • Cloning of syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis
    • Melby P.C., Tryon V.V., Chandrasekar B., and Freeman G.L. Cloning of syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis. Infection and Immunity 66 (1998) 2135-2142
    • (1998) Infection and Immunity , vol.66 , pp. 2135-2142
    • Melby, P.C.1    Tryon, V.V.2    Chandrasekar, B.3    Freeman, G.L.4
  • 27
    • 0011545343 scopus 로고    scopus 로고
    • Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis
    • Mielke M.E., Peters C., and Hahn H. Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis. Immunological Reviews 158 (1997) 79-93
    • (1997) Immunological Reviews , vol.158 , pp. 79-93
    • Mielke, M.E.1    Peters, C.2    Hahn, H.3
  • 28
    • 0037456693 scopus 로고    scopus 로고
    • A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. Infantum
    • Molano I., Alonso M.G., Miron C., Redondo E., Requena J.M., Soto M., et al. A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. Infantum. Veterinary Immunology and Immunopathology 92 (2003) 1-13
    • (2003) Veterinary Immunology and Immunopathology , vol.92 , pp. 1-13
    • Molano, I.1    Alonso, M.G.2    Miron, C.3    Redondo, E.4    Requena, J.M.5    Soto, M.6
  • 29
    • 0032532640 scopus 로고    scopus 로고
    • Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani
    • Murphy M.L., Cotterell S., Gorak M., Engwerda C.R., and Kaye P.M. Blockade of CTLA-4 enhances host resistance to the intracellular pathogen, Leishmania donovani. Journal of Immunology 161 (1998) 4153-4160
    • (1998) Journal of Immunology , vol.161 , pp. 4153-4160
    • Murphy, M.L.1    Cotterell, S.2    Gorak, M.3    Engwerda, C.R.4    Kaye, P.M.5
  • 30
    • 0025266647 scopus 로고
    • Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis
    • Murray H.W. Effect of continuous administration of interferon-γ in experimental visceral leishmaniasis. Journal of Infectious Diseases 161 (1990) 992-994
    • (1990) Journal of Infectious Diseases , vol.161 , pp. 992-994
    • Murray, H.W.1
  • 31
    • 0002172660 scopus 로고    scopus 로고
    • Granulomatous inflammation: host antimicrobial defense in the tissues in visceral leishmaniasis
    • Gallin J., Synderman R., Fearon D., Haynes B., and Nathan C. (Eds), Lippincott-Raven, Philadelphia
    • Murray H.W. Granulomatous inflammation: host antimicrobial defense in the tissues in visceral leishmaniasis. In: Gallin J., Synderman R., Fearon D., Haynes B., and Nathan C. (Eds). Inflammation: Basic Principles and Clinical Correlates. third ed. (1999), Lippincott-Raven, Philadelphia 77-994
    • (1999) Inflammation: Basic Principles and Clinical Correlates. third ed. , pp. 77-994
    • Murray, H.W.1
  • 32
    • 0034913328 scopus 로고    scopus 로고
    • Clinical and experimental advances in treatment of visceral leishmaniasis
    • Murray H.W. Clinical and experimental advances in treatment of visceral leishmaniasis. Antimicrobial Agents and Chemotherapy 45 (2001) 2185-2197
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , pp. 2185-2197
    • Murray, H.W.1
  • 34
    • 0035151414 scopus 로고    scopus 로고
    • Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study
    • Pintado V., Marti{dotless}́n-Rabadán P., Rivera M.L., Moreno S., and Bouza E. Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study. Medicine (Baltimore) 80 (2001) 54-73
    • (2001) Medicine (Baltimore) , vol.80 , pp. 54-73
    • Pintado, V.1    Martín-Rabadán, P.2    Rivera, M.L.3    Moreno, S.4    Bouza, E.5
  • 35
    • 0037992584 scopus 로고    scopus 로고
    • Development of a leishmaniasis vaccine: the importance of MPL
    • Reed S.G., Coler R.N., and Campos-Neto A. Development of a leishmaniasis vaccine: the importance of MPL. Expert Reviews in Vaccines 2 (2003) 239-252
    • (2003) Expert Reviews in Vaccines , vol.2 , pp. 239-252
    • Reed, S.G.1    Coler, R.N.2    Campos-Neto, A.3
  • 36
    • 0031841564 scopus 로고    scopus 로고
    • Liposomes containing lipid A serve as an adjuvant for induction of antibody and cytotoxic T-cell responses against RTS, S malaria antigen
    • Richards R., Rao M., Wassef N., Glenn G., Rothwell S., and Alving C. Liposomes containing lipid A serve as an adjuvant for induction of antibody and cytotoxic T-cell responses against RTS, S malaria antigen. Infection and Immunity 66 (1998) 2859-2865
    • (1998) Infection and Immunity , vol.66 , pp. 2859-2865
    • Richards, R.1    Rao, M.2    Wassef, N.3    Glenn, G.4    Rothwell, S.5    Alving, C.6
  • 37
    • 0025940127 scopus 로고
    • Role of inorganic nitrogen oxides and tumor necrosis factor α in killing Leishmania donovani amastigotes in γ interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains
    • Roach T.I., Kiderlen A.F., and Blackwell J.M. Role of inorganic nitrogen oxides and tumor necrosis factor α in killing Leishmania donovani amastigotes in γ interferon-lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains. Infection and Immunity 59 (1991) 3935-3944
    • (1991) Infection and Immunity , vol.59 , pp. 3935-3944
    • Roach, T.I.1    Kiderlen, A.F.2    Blackwell, J.M.3
  • 38
    • 27744493936 scopus 로고    scopus 로고
    • Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection
    • Roberts M.T., Stober C.B., McKenzi A.N., and Blackwell J.M. Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection. Infection and Immunity 73 (2005) 7620-7628
    • (2005) Infection and Immunity , vol.73 , pp. 7620-7628
    • Roberts, M.T.1    Stober, C.B.2    McKenzi, A.N.3    Blackwell, J.M.4
  • 40
    • 0030955186 scopus 로고    scopus 로고
    • Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1
    • Sasaki S., Tsuji T., Hamajima K., Fukushima J., Ishii N., Kaneko T., et al. Monophosphoryl lipid A enhances both humoral and cell-mediated immune responses to DNA vaccination against human immunodeficiency virus type 1. Infection and Immunity 65 (1997) 3520-3528
    • (1997) Infection and Immunity , vol.65 , pp. 3520-3528
    • Sasaki, S.1    Tsuji, T.2    Hamajima, K.3    Fukushima, J.4    Ishii, N.5    Kaneko, T.6
  • 41
    • 0023257259 scopus 로고
    • Vaccination against cutaneous leishmaniasis in a murine model. 1. Induction of protective immunity with a soluble extract of promastigotes
    • Scott P., Pearce E., Natovitz P., and Sher A. Vaccination against cutaneous leishmaniasis in a murine model. 1. Induction of protective immunity with a soluble extract of promastigotes. Journal of Immunology 139 (1987) 221-227
    • (1987) Journal of Immunology , vol.139 , pp. 221-227
    • Scott, P.1    Pearce, E.2    Natovitz, P.3    Sher, A.4
  • 42
    • 0032984248 scopus 로고    scopus 로고
    • Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase
    • Shiloh M.U., MacMicking J.D., Nicholson S., Brause J.E., Potter S., Marino M., et al. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10 (1999) 29-38
    • (1999) Immunity , vol.10 , pp. 29-38
    • Shiloh, M.U.1    MacMicking, J.D.2    Nicholson, S.3    Brause, J.E.4    Potter, S.5    Marino, M.6
  • 43
    • 0033577295 scopus 로고    scopus 로고
    • Long-term protection of mice against Leishmania major with a synthetic peptide vaccine
    • Spitzer N., Jardim A., Lippert D., and Olafson R.W. Long-term protection of mice against Leishmania major with a synthetic peptide vaccine. Vaccine 17 (1999) 1298-1300
    • (1999) Vaccine , vol.17 , pp. 1298-1300
    • Spitzer, N.1    Jardim, A.2    Lippert, D.3    Olafson, R.W.4
  • 44
    • 0024805717 scopus 로고
    • Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response
    • Squires K.E., Schreibe R.D., McElrath M.J., Rubin B.Y., Anderson S.L., and Murray H.W. Experimental visceral leishmaniasis: role of endogenous IFN-γ in host defense and tissue granulomatous response. Journal of Immunology 143 (1989) 4244-4249
    • (1989) Journal of Immunology , vol.143 , pp. 4244-4249
    • Squires, K.E.1    Schreibe, R.D.2    McElrath, M.J.3    Rubin, B.Y.4    Anderson, S.L.5    Murray, H.W.6
  • 45
    • 0034671822 scopus 로고    scopus 로고
    • Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis
    • Stager S., Smith D.F., and Kaye P.M. Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis. Journal of Immunology 165 (2000) 7064-7071
    • (2000) Journal of Immunology , vol.165 , pp. 7064-7071
    • Stager, S.1    Smith, D.F.2    Kaye, P.M.3
  • 46
    • 84981840703 scopus 로고
    • An eight day method for screening compounds against Leishmania donovani in the golden hamster
    • Stauber L.A., Franchino E.M., and Grun J. An eight day method for screening compounds against Leishmania donovani in the golden hamster. Journal of Protozoology 5 (1958) 269-273
    • (1958) Journal of Protozoology , vol.5 , pp. 269-273
    • Stauber, L.A.1    Franchino, E.M.2    Grun, J.3
  • 47
    • 23444440849 scopus 로고    scopus 로고
    • IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection
    • Stober C.B., Lange U.G., Roberts M.T., Alcami A., and Blackwell J.M. IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection. Journal of Immunology 175 (2005) 2517-2524
    • (2005) Journal of Immunology , vol.175 , pp. 2517-2524
    • Stober, C.B.1    Lange, U.G.2    Roberts, M.T.3    Alcami, A.4    Blackwell, J.M.5
  • 48
    • 3843131921 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides are potent enhancers of protective immunity in mice immunized with recombinant ORFF leishmanial antigen
    • Tewary P., Sukumaran B., Saxena S., and Madhubala R. Immunostimulatory oligodeoxynucleotides are potent enhancers of protective immunity in mice immunized with recombinant ORFF leishmanial antigen. Vaccine 22 (2004) 3053-3060
    • (2004) Vaccine , vol.22 , pp. 3053-3060
    • Tewary, P.1    Sukumaran, B.2    Saxena, S.3    Madhubala, R.4
  • 49
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
    • Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of National Academy of Sciences, USA 76 (1979) 4350-4354
    • (1979) Proceedings of National Academy of Sciences, USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 50
    • 0036117769 scopus 로고    scopus 로고
    • Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp.
    • Travi B.L., Osorio Y., Melby P.C., Chandrasekar B., Arteaga L., and Saravia N.G. Gender is a major determinant of the clinical evolution and immune response in hamsters infected with Leishmania spp. Infection and Immunity 70 (2002) 2288-2296
    • (2002) Infection and Immunity , vol.70 , pp. 2288-2296
    • Travi, B.L.1    Osorio, Y.2    Melby, P.C.3    Chandrasekar, B.4    Arteaga, L.5    Saravia, N.G.6
  • 51
    • 0029201182 scopus 로고
    • Monophosphoryl lipid A as an adjuvant
    • Powell M.F., and Newman M.J. (Eds), Plenum Press, New York
    • Ulrich J.T., and Myers K.R. Monophosphoryl lipid A as an adjuvant. In: Powell M.F., and Newman M.J. (Eds). Vaccine Design: The Subunit and Adjuvant Approach (1995), Plenum Press, New York 495-524
    • (1995) Vaccine Design: The Subunit and Adjuvant Approach , pp. 495-524
    • Ulrich, J.T.1    Myers, K.R.2
  • 52
    • 0028952707 scopus 로고
    • A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice
    • Wilson M.E., Young B.M., Andersen K.P., Weinstock J.V., Metwali A., Ali K.M., et al. A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice. Infection and Immunity 63 (1995) 2062-2069
    • (1995) Infection and Immunity , vol.63 , pp. 2062-2069
    • Wilson, M.E.1    Young, B.M.2    Andersen, K.P.3    Weinstock, J.V.4    Metwali, A.5    Ali, K.M.6
  • 53
    • 0028075996 scopus 로고
    • Monophosphoryl lipid A protects against endotoxic shock via inhibiting neutrophil infiltration and preventing disseminated intravascular coagulation
    • Yao Z., Foster P.A., and Gross G.J. Monophosphoryl lipid A protects against endotoxic shock via inhibiting neutrophil infiltration and preventing disseminated intravascular coagulation. Circulatory Shock 43 (1994) 107-114
    • (1994) Circulatory Shock , vol.43 , pp. 107-114
    • Yao, Z.1    Foster, P.A.2    Gross, G.J.3
  • 54
    • 7044254507 scopus 로고    scopus 로고
    • Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites
    • Zaph C., Uzonna J., Beverley S.M., and Scott P. Central memory T cells mediate long-term immunity to Leishmania major in the absence of persistent parasites. Nature Medicine 10 (2004) 1104-1110
    • (2004) Nature Medicine , vol.10 , pp. 1104-1110
    • Zaph, C.1    Uzonna, J.2    Beverley, S.M.3    Scott, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.