Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection

Infection and Immunity

Volumn 73, Issue 11, 2005, Pages 7620-7628

  Roberts, Mark T M ^a   Stober, Carmel B ^a   McKenzie, Andrew N ^b   Blackwell, Jenefer M ^a,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA VACCINE; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; EXPRESSED SEQUENCE TAG; FEMALE; GENE DISRUPTION; IMMUNE RESPONSE; IMMUNOGENICITY; KNOCKOUT MOUSE; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

ANIMALS; ANTIBODIES; ANTIGENS, PROTOZOAN; DISEASE PROGRESSION; DISEASE SUSCEPTIBILITY; FEMALE; INTERLEUKIN-10; INTERLEUKIN-4; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTOZOAN VACCINES; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10; TH2 CELLS; TIME FACTORS; TREATMENT FAILURE;

EID: 27744493936     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.11.7620-7628.2005     Document Type: Article

References (24)

1. Almeida, A. S., B. J. Gilmartin, S. McCann, A. Norrish, A. Ivens, D. Lawson, M. P. Levick, D. F. Smith, S. D. Dyall, D. Vetrie, T. C. Freeman, R. M. Coulson, I. Sampaio, H. Schneider, and J. M. Blackwell. 2004. Expression profiling of the Leishmania life cycle: cDNA arrays identify developmentally regulated genes present but not annotated in the genome. Mol. Biochem. Parasitol. 136:87-100.
2. Antonelli, L. R., W. O. Dutra, R. P. Almeida, O. Bacellar, and K. J. Gollob. 2004. Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin. Exp. Immunol. 136:341-348.
3. Arendse, B., J. Van Snick, and F. Brombacher. 2005. IL-9 is a susceptibility factor in Leishmania major infection by promoting detrimental Th2/type 2 responses. J. Immunol. 174:2205-2211.
4. Bourreau, E., M. Collet, G. Prevot, G. Milon, D. Ashimoff, H. Hasagewa, C, Parra-Lopez, and P. Launois. 2002. IFN-gamma-producing CD45RA+ CD8+ and IL-10-producing CD45RA-CD4+ T cells generated in response to LACK in naive subjects never exposed to Leishmania. Eur. J. Immunol. 32:510-520.
5. Carvalho, L. P., S. Passos, W. O. Dutra, M. Soto, C. Alonso, K. J. Gollob, E. M. Carvalho, and A. Ribeiro de Jesus. 2005. Effect of LACK and KMP11 on IFN-γ production by peripheral blood mononuclear cells from cutaneous and mucocutaneous leishmaniasis patients. Scand. J. Immunol. 61:337-342.
6. de Carvalho, L. P., M. Soto, S. Jeronimo, B. Dondji, O. Bacellar, V. Luz, G. Orge Orge, C. Alonso, A. R. Jesus, and E. M. Carvalho. 2003. Characterization of the immune response to Leishmania infantum recombinant antigens. Microbes Infect. 5:7-12.
7. Fallon, P. G., H. E. Jolin, P. Smith, C. L. Emson, M. J. Townsend, R. Fallon, and A. N. McKenzie. 2002. IL-4 induces characteristic Th2 responses even in the combined absence of IL-5. IL-9, and IL-13. Immunity 17:7-17.
8. Gessner, A., H. Blum, and M. Rollinghoff. 1993. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology 189:419-435.
9. Groux, H., A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, J. E. de Vries, and M. G. Roncarolo. 1997. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737-742.
10. Julia, V., S. S. McSorley, L. Malherbe, J. P. Breittmayer, F. Girard-Pipau, A. Beck, and N. Glaichenhaus. 2000. Priming by microbial antigens from the intestinal flora determines the ability of CD4+ T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania major. J. Immunol. 165:5637-5645.
11. Kuhn, R., K. Rajewsky, and W. Muller. 1991. Generation and analysis of interleukin-4-deficient mice. Science 254:707-710.
12. Levick, M. P., J. M. Blackwell, V. Connor, R. M. Coulson, A. Miles, H. E. Smith, K. L. Wan, and J. W. Ajioka. 1996. An expressed sequence tag analysis of a full-length, spliced-leader cDNA library from Leishmania major promastigotes. Mol. Biochem. Parasitol. 76:345-348.
13. Maasho, K., I. Satti, S. Nylen, G. Guzman, F. Koning, and H. Akuffo. 2000. A Leishmania homologue of receptors for activated C-kinase (LACK) induces both interferon-gamma and interleukin-10 in natural killer cells of healthy blood donors. J. Infect. Dis. 182:570-578.
14. Matthews, D. J., C. L. Emson, G. J. McKenzie, H. E. Jolin, J. M. Blackwell, and A. N. McKenzie. 2000. IL-13 is a susceptibility factor for Leishmania major infection. J. Immunol. 164:1458-1462.
15. McGuirk, P., C. McCann, and K. H. Mills. 2002. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195:221-231.
16. McKenzie, G. J., P. G. Fallon, C. L. Emson, R. K. Grencis, and A. N. McKenzie. 1999. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189:1565-1572.
17. Mendel, I., and E. M. Shevach. 2002. The IL-10-producing competence of Th2 cells generated in vitro is IL-4 dependent. Eur. J. Immunol. 32:3216-3224.
18. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z.-E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563-566.
19. Nashed, B. F., Y. Maekawa, M. Takashima, T. Zhang, K. Ishii, T. Dainichi, H. Ishikawa, T. Sakai, H. Hisaeda, and K. Himeno. 2000. Different cytokines are required for induction and maintenance of the Th2 type response in DBA/2 mice resistant to infection with Leishmania major. Microbes Infect. 2:1435-1443.
20. Noben-Trauth, N., R. Lira, H. Nagase, W. E. Paul, and D. L. Sacks. 2003. The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. J. Immunol. 170:5152-5158.
21. Stober, C., U. Lange, M. T. Roberts, B. C. Gilbmartin, R. Francis, R. Almeida, C. S. Peacock, S. McCann, and J. M. Blackwell. From genome to vaccines for leishmaniasis: screening 100 novel vaccine candidates against murine Leishmania major infection. Submitted for publication.
22. Stober, C., U. Lange, M. T. M. Roberts, A. Alcami, and J. M. Blackwell. 2005. IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection. J. Immunol. 175:2517-2514.
23. Swihart, K., U. Fruth, N. Messmer, K. Hug, R. Behin, S. Huang, G. Del Giudice, M. Aguet, and J. A. Louis. 1995. Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T-cell response. J. Exp. Med. 181:961-971.
24. Wang, Z. E., S. L. Reiner, S. Zheng, D. K. Dalton, and R. M. Locksley. 1994. CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.