Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradation and morphine tolerance

Pain

Volumn 140, Issue 3, 2008, Pages 472-478

  Yang, Liling ^a   Wang, Shuxing ^a   Lim, Grewo ^a   Sung, Backil ^a   Zeng, Qing ^a   Mao, Jianren ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

EAAC1; GLAST; GLT 1; Glutamate transporter; MG 132; Morphine tolerance

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLUTAMATE TRANSPORTER; MORPHINE; PROTEASOME; PROTEASOME INHIBITOR; UBIQUITIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG TOLERANCE; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; CYSTEINE PROTEINASE INHIBITORS; DOWN-REGULATION; DRUG TOLERANCE; GLUTAMIC ACID; INJECTIONS, SPINAL; LEUPEPTINS; MALE; MORPHINE; PAIN; POSTERIOR HORN CELLS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TREATMENT OUTCOME; UBIQUITIN; VESICULAR GLUTAMATE TRANSPORT PROTEINS;

EID: 57049160340     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.09.028     Document Type: Article

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