The effect of low-dose cholecalciferol and calcium treatment on posttransplant bone loss in renal transplant patients: A prospective study

Renal Failure

Volumn 30, Issue 10, 2008, Pages 992-999

  Sahin, Garip ^a   Yasar, Nazife Sule ^a   Sirmagul, Basar ^a   Bal, Cengiz ^a   Yalcin, Ahmet Ugur ^a  

^a OSMANGAZI UNIVERSITY MEDICAL FACULTY   (Turkey)

Author keywords

25 hydroxy vitamin D3; Bone mineral density; Cholecalciferol; Renal transplantation

Indexed keywords

C REACTIVE PROTEIN; CALCIUM; CHOLESTEROL; COLECALCIFEROL; CREATININE; HEMOGLOBIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITROGEN; PARATHYROID HORMONE; PRAVASTATIN; TRIACYLGLYCEROL; UREA;

ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; CALCIUM BLOOD LEVEL; CALCIUM INTAKE; CALCIUM URINE LEVEL; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; CREATININE URINE LEVEL; FEMUR; FEMUR NECK; KIDNEY GRAFT; LOW DRUG DOSE; LUMBAR SPINE; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; POSTTRANSPLANT OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL; VITAMIN BLOOD LEVEL;

ADRENAL CORTEX HORMONES; ADULT; BONE DENSITY; BONE RESORPTION; CALCIUM; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; FEMALE; HUMANS; IMMUNOSUPPRESSION; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; OSTEOPOROSIS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 57049159363     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.1080/08860220802406369     Document Type: Article

References (35)

1. Monier-Faugere MC, Mawad H, Qi Q, Friedler RM, Malluche HH. High prevalence of low bone turnover and occurrence of osteomalacia after kidney transplantation. J Am Soc Nephrol. 2000;11:1093-1099.
2. Heaf JG. Bone disease after renal transplantation. Transplantation. 2003;75:315-325.
3. Heaf J, Tvedegaard E, Kanstrup IL, Fogh-Andersen N. Hyperparathyroidism and long-term bone loss after renal transplantation. Clin Transplant. 2003;17:268-274.
4. Julian BA, Laskow DA, Dubovsky J, Dubousky EV, Curtis JJ, Quarless LD. Rapid loss of vertebral mineral density after renal transplantation. N Engl J Med. 1991Aug 22;325(8):544-550.
5. Velazquez-Forero F, Mondragon A, Herrero B, Pena JC. Adynamic bone lesion in renal transplant recipients with normal renal function. Nephrol Dial Transplant. 1996;11 (Suppl.):58-64.
6. Talalaj M, Gradowska L, Marcinowska-Suchowierska E, Durlik M, Gaciong Z, Lao M. Efficiency of preventive treatment of glucocorticoid-induced osteoporosis with 25-hydroxyvitamin D3 and calcium in kidney transplant patients. Transplant Proc. 1996 Dec;28(6):3485-3487.
7. Almond NK, Kwan JTC, Evans K, Cunningham J. Loss of regional bone mineral density in the first 12 months following renal transplantation. Nephron. 1994;66:52-57.
8. Carlini RG, Rojas E, Weisinger JR, et al. Bone disease in patients with long-term renal transplantation and normal renal function. Am J Kidney Dis. 2000;36(1):160-166.
9. Adachi JD, Bensen WG, Hodsman AB. Corticosteroid-induced osteoporosis. Semin Arthritis Rheum. 1993;22:375-384.
10. Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102(2):274-282.
11. Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: Pathogenesis and management. Ann Intern Med. 1990;112(5):352-364.
12. Cohen A, Shane E. Osteoporosis after solid organ and bone marrow transplantation. Osteoporos Int. 2003;14(8):617-630.
13. Epstein S. Post-transplantation bone disease: The role of immunosuppressive agents on the skeleton. J Bone Miner Res. 1996;11(1):1-7.
14. Cvetkovic M, Mann GN, Romero DF, et al. The deleterious effects of long-term cyclosporin A, cyclosporin G, and FK 506 on bone mineral metabolism in vivo. Transplantation. 1994;57(8):1231-1237.
15. Schlosberg M, Mosvowitz C, Epstein S, Ismail F, Fallon MD, Thomas S. The effects of cyclosporin A administration and its withdrawal on bone mineral metabolism in the rat. Endocrinology. 1989;124(5):2179-2184.
16. Westeel FP, Mazouz H, Ezaituni F, et al. Cyclosporine bone remodeling effect prevents steroid osteopenia after kidney transplantation. Kidney Int. 2000;58:1788-1796.
17. Recommendations for the prevention and treatment of glucocorticoid-indced osteoporosis: 2001 update. American College of Rheumatolog Ad Hoc Committee on Glucocorticoid-Induced Osteoporosis. Arthritis Rheum. 2001;44(7):1496-1503.
18. Holick MF. Vitamin D: A millennium perspective. J Cell Biochem. 2003;88:296-307.
19. World Health Organization. Assessment of fracture risk and its application screening for postmenopausal osteoporosis. Report of WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1-129.
20. Horber FF, Casez JP, Steiger U, Czemiak A, Montandon A, Jaeger P. Changes in bone mass early after kidney transplantation. J Bone Miner Res. 1994;9(1):1-9.
21. Aroldi A, Tarantino A, Montagnino G, Cesana B, Cocucci C, Ponticelli C. Effects of three immunosuppressive regimens on vertebral bone density in renal transplant recipients: A prospective study. Transplantation. 1997;63(3):380-386.
22. Grotz WH, Mundinger FA, Rasenack J, et al. Bone loss after kidney transplantation: A longitudinal study in 115 graft recipients. Nephrol Dial Transplant. 1995;10(11):2096-2100.
23. de Sevaux RG, Hoitsma AJ, van Hoof HJ, Corstens FJ, Wetzels JF. Abnormal vitamin D metabolism and loss of bone mass after renal transplantation. Nephron Clin Pract. 2003;93(1):C21-C28.
24. Grotz W, Nagel C, Poeschel D, et al. Effect of ibandronate on bone loss and renal function after kidney transplantation. J Am Soc Nephrol. 2001;12(7):1530-1537.
25. de Sevaux RG, Hoitsma AJ, Corstens FH, Wetzels JF. Treatment with vitamin D and calcium reduces bone loss after renal transplantation: A randomized study. J Am Soc Nephrol. 2002;13(6):1608-1614.
26. Mikuls TR, Julian BA, Bartolucci A, Saag KG. Bone mineral density changes within six months of renal transplantation. Transplantation. 2003;75(1):49-54.
27. Wissing KM, Broeders N, Moreno-Reyes R, Gervy C, Stallenberg B, Abramowicz D. A controlled study of vitamin D3 to prevent bone loss in renal-transplant patients receiving low doses of steroids. Transplantation. 2005;79(1):108-115.
28. Canalis E. Clinical review 83: Mechanisms of glucocorticoid action in bone: Implications to glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab. 1996;81(10):3441-3447.
29. Moorhead JF, Will MR, Ahmed KY, Baillad RA, Varghese Z, Tatler GL. Hypophosphatemic osteomalacia after cadavericrenal transplantation. Lancet. 1974;1(7860):694-697.
30. Levi M. Post-transplant hypophosphatemia. Kidney Int. 2001;59(6):2377-2387.
31. Fan SL, Almond MK, Ball E, Evans K, Cunningham J. Pamidronate therapy as prevention of bone loss following renal transplantation. Kidney Int. 2000;57(2):684-690.
32. Coco M, Glicklich D, Faugere MC, et al. Prevention of bone loss in renal transplant recipients: A prospective, randomized trial of intravenous pamidronate. J Am Soc Nephrol. 2003;14(10):2669-2676.
33. Cruz DN, Wysolerski JJ, Brickel HM, et al. Parameters of high bone turnover predict bone loss in renal transplant patients: A longitudinal study. Transplantation. 2001;72(1):83-88.
34. Stein M, Packham D, Ebeling P, Wark JD, Becker GJ. Prevelance and risk factors for osteoporosis in dialysis patients. Am J Kidney Dis. 1996;28(4):515-522.
35. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69 (4):842-856.