Expanding Donor Options: Marginal, Living, and Split Donors

Clinics in Liver Disease

Volumn 11, Issue 2, 2007, Pages 417-429

  Foster, Richard ^a   Zimmerman, Michael ^b   Trotter, James F ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B ANTIBODY; LAMIVUDINE;

COMBINATION CHEMOTHERAPY; DONOR SELECTION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART DEATH; HEPATITIS B; HUMAN; LIVER BIOPSY; LIVER GRAFT; LIVER RESECTION; LIVER TRANSPLANTATION; LIVING DONOR; MORBIDITY; MORTALITY; ORGAN DONOR; OUTCOME ASSESSMENT; REVIEW; SURGICAL TECHNIQUE; TREATMENT OUTCOME; VIRUS INFECTION;

DONOR SELECTION; HUMANS; LIVER DISEASES; LIVER TRANSPLANTATION;

EID: 34250849252     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2007.04.004     Document Type: Review

References (86)

1. The Organ Procurement and Transplant Network. Transplants by donor type; liver. Available at: www.optn.org. Accessed July 17, 2006.
2. Cameron A., and Busuttil R. AASLD/ILTS transplant course: is there an extended donor suitable for everyone?. Liver Transpl 11 11 Suppl 1 (2005) S2-S5
3. Renz J., Kin C., Kinkhabwala M., et al. Utilization of extended donor criteria liver allografts maximizes donor use and patient access to liver transplantation. Ann Surg 242 (2005) 556-563
4. Yanaga K., Tzakis A., and Starzl T. Personal experience with the procurement of 132 liver allografts. Transpl Int 2 (1989) 137-142
5. Greig P., Forster J., Superina R., et al. Donor-specific factors predict graft function following liver transplantation. Transplant Proc 22 (1990) 2072-2073
6. Mor E., Klintmalm G., Gonwa T., et al. The use of marginal donors for liver transplantation: a retrospective study of 365 liver donors. Transplantation 53 (1992) 383-386
7. Ploeg R., D'Alessandro A., Knechtle S., et al. Risk factors for primary dysfunction after liver transplantation-a multivariate analysis. Transplantation 55 (1993) 807-813
8. Gruenberger T., Steininger R., Sautner T., et al. Influence of donor criteria on postoperative graft function after orthotopic liver transplantation. Transpl Int 7 (1994) S672-S674
9. Gonzalez F., Rimola A., Grande L., et al. Predictive factors of early postoperative graft function in human liver transplantation. Hepatology 20 (1994) 565-573
10. Markmann J.F., Markmann J.W., Markmann D., et al. Preoperative factors associated with outcome and their impact on resource use in 1148 consecutive primary liver transplants. Transplantation 72 (2001) 1113-1122
11. Briceno J., Marchal T., Padillo J., et al. Influence of marginal donors on liver preservation injury. Transplantation 74 (2002) 522-526
12. Rull R., Vidal O., Momblan D., et al. Evaluation of potential liver donors: limits imposed by donor variables in liver transplantation. Liver Transpl 9 (2003) 389-393
13. Cuende N., Miranda B., Canon J., et al. Donor characteristics associated with liver graft survival. Transpantation 79 (2005) 1445-1452
14. Busuttil R., Farmer D., Yersiz H., et al. Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single center experience. Ann Surg 241 (2005) 905-918
15. Cameron A., Ghobrial R., Yersiz H., et al. Optimal utilization of donor grafts with extended criteria: a single center experience in over 1000 liver transplants. Ann Surg 243 (2006) 748-755
16. Feng S., Goodrich N., Bragg-Gresham J., et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 6 (2006) 783-790
17. Loinaz C., and Gonzalez E. Marginal donors in liver transplantation. Hepatogastroenterology 47 (2000) 257-263
18. Busuttil R., and Tanaka K. The utility of marginal donors in liver transplantation. Liver Transpl 9 (2003) 651-663
19. Rodriguez-Luna H., Arenas J., and Vargas H. The use of virologically compromised organs in liver transplantation. Clin Liver Dis 7 (2003) 573-584
20. Dodson S., Bonham C., Geller D., et al. Prevention of de novo hepatitis B infection in recipients of hepatic allografts from anti-HBc positive donors. Transplantation 68 (1999) 1058-1061
21. Joya-Vazquez J., Dodson F., Dvorchik I., et al. Impact of anti-hepatitis Bc-positive grafts on the outcome of liver transplantation for HBV-related cirrhosis. Transplantation 73 (2002) 1598-1602
22. Nery J., Nery-Avila C., Reddy K., et al. Use of liver grafts from donors positive for antihepatitis B-core antibody (anti-HBc) in the era of prophylaxis with hepatitis-B immunoglobulin and lamivudine. Transplantation 75 (2003) 1179-1186
23. Fabrega E., Garcia-Suarez C., Guerra A., et al. Liver transplantation with allografts from hepatitis B core antibody-positive donors: a new approach. Liver Transpl 9 (2003) 916-920
24. Manzarbeitia C., Reich D., Ortiz J., et al. Safe use of livers from donors with positive hepatitis B core antibody. Liver Transpl 8 (2002) 556-561
25. Burton J., and Shaw-Stiffel T. Use of hepatitis B core antibody-positive donors in recipients without evidence of hepatitis B infection: a survey of current practice in the United States. Liver Transpl 9 (2003) 837-842
26. Pereira B., Milford E., Kirkman R., et al. Prevalence of hepatitis C virus RNA in organ donors positive for hepatitis C antibody and in the recipients of their organs. N Engl J Med 327 (1992) 910-915
27. Ghobrial R., Steadman R., Gornbein J., et al. A 10-year experience of liver transplantation for hepatitis C: analysis of factors determining outcome in over 500 patients. Ann Surg 234 (2001) 384-394
28. Marroquin C., Marino G., Kuo P., et al. Transplantation of hepatitis c-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers. Liver Transpl 7 (2001) 762-768
29. Ricchiuti A., Brunati A., Mirabella S., et al. Use of hepatitis C virus-positive grafts in liver transplantation: a single-centre experience. Transplant Proc 37 (2005) 2569-2570
30. Vargas H., Laskus T., Wang L., et al. Outcome of liver transplantation in hepatitis C virus-infected patients who received hepatitis C virus-infected grafts. Gastroenterology 117 (1999) 149-153
31. Testa G., Goldstein R., Netto G., et al. Long-term outcome of patients transplanted with livers from hepatitis C-positive donors. Transplantation 65 (1998) 925-929
32. Velidedeoglu E., Desai N., Campos L., et al. The outcome of liver grafts procured from hepatitis C-positive donors. Transplantation 73 (2002) 582-587
33. Casavilla A., Ramirez C., Shapiro R., et al. Experience with liver and kidney allografts from non-heart-beating donors. Transplantation 59 (1995) 197-203
34. Foley D., Fernandez L., Leverson G., et al. Donation after cardiac death: the University of Wisconsin experience with liver transplantation. Ann Surg 242 (2005) 724-731
35. Bernat J., D'Alessandro A., Port T., et al. Report of a national conference on donation after cardiac death. Am J Transplant 6 (2006) 281-291
36. Lewis J., Peltier J., Nelson H., et al. Development of the University of Wisconsin donation after cardiac death evaluation tool. Prog Transplant 13 (2003) 265-273
37. United Network for Organ Sharing. Donor management; the critical pathway for the organ donor; critical pathway for donation after cardiac death. Available at: www.unos.org. Accessed August 22, 2006.
38. Abt P., Desai N., Crawford M., et al. Survival following liver transplantation from non-heart-beating donors. Ann Surg 239 (2004) 87-92
39. Manzarbeitia C., Ortiz J., Jeon H., et al. Long-term outcome of controlled, non-heart-beating donor liver transplantation. Transplantation 78 (2004) 211-215
40. Mateo R., Cho Y., Singh G., et al. Risk factors for graft survival after liver transplantation from donation after cardiac death donors: an analysis of OPTN/UNOS data. Am J Transplant 6 (2006) 791-796
41. Abt P., Crawford M., Desai N., et al. Liver transplantation from controlled non-heart-beating donors: an increased incidence of biliary complications. Transplantation 75 (2003) 1659-1663
42. Yersiz H., Cameron A.M., Carmody I., et al. Split liver transplantation. Transplant Proc 38 (2006) 602-603
43. Smith B. Segmental liver transplantation from a living donor. J Pediatr Surg 4 (1969) 126-132
44. Pichlmayr R., Ringe B., and Gubernatis G. Transplantation of a donor liver to 2 recipients (splitting transplantation)-a new method in the further development of segmental liver transplantation. Langenbeck Arch Chir 373 (1989) 127-130
45. Bismuth H., Morino M., Castaing D., et al. Emergency orthotopic liver transplantation in two patients using one donor liver. Br J Surg 76 (1989) 722-724
46. Renz J.F., Yersiz H., Reichert P.R., et al. Split-liver transplantation: a review. Am J Transplant 3 (2003) 1323-1335
47. Azoulay D., Astarcioglu I., Bismuth H., et al. Split-liver transplantation: the Paul Brousse policy. Ann Surg 224 (1996) 737-746
48. Humar A., Ramcharan T., Sielaff T., et al. Split liver transplantation for two adult recipients: an initial experience. Am J Transplant 1 (2001) 366-372
49. Yersiz H., Renz J.F., Farmer D.G., et al. One hundred in situ split-liver transplantations: a single-center experience. Ann Surg 238 (2003) 496-507
50. Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg 6 (1982) 3-9
51. Ghobrial R.M., Yersiz H., Farmer D.G., et al. Predictors of survival after in vivo split liver transplantation: analysis of 110 consecutive patients. Ann Surg 232 (2000) 312-323
52. Cardillo M., De Fazio N., Pedotti P., et al. Split and whole liver transplantation outcomes: a comparative cohort study. Liver Transpl 12 (2006) 402-410
53. Renz J.F., Emond J.C., Yersiz H., et al. Split-liver transplantation in the United States: outcomes of a national survey. Ann Surg 239 (2004) 172-181
54. Schiano T., Kim-Schluger L., Gondolesi G., et al. Adult living donor liver transplantation: the hepatologist's perspective. Hepatology 33 (2001) 3-9
55. Trotter J., Wachs M., Everson G., et al. Adult-to-adult transplantation of the right hepatic lobe from a living donor. N Engl J Med 346 (2002) 1074-1082
56. Kam I. Adult-adult right hepatic lobe living donor liver transplantation for status 2a patients: too little, too late. Liver Transpl 8 (2002) 347-349
57. Trotter J., Campsen J., Bak T., et al. Outcomes of donor evaluations for adult-to-adult right hepatic lobe living donor liver transplantation. Am J Transplant 6 (2006) 1882-1889
58. Neuhaus P. Live donor/split liver grafts for adult recipients: when should we use them?. Liver Transpl 11 (2005) S6-S9
59. Trotter J. Living donor liver transplantation: is the hype over?. J Hepatol 42 (2005) 20-25
60. Trotter J. Selection of donor and recipients for living donor liver transplantation. Liver Transpl 6 (2000) S52-S58
61. Yamashiki N., Sugawara Y., Tamura S., et al. Selection of liver-transplant candidates for adult-to-adult living donor liver transplantation as the only surgical option for end-stage liver disease. Liver Transpl 12 (2006) 1077-1083
62. Olthoff K., Merion R., Ghobrial R., et al. Outcomes of 385 adult-to-adult living donor liver transplant recipients: a report from the A2ALL Consortium. Ann Surg 242 (2005) 314-323
63. The Organ Procurement and Transplant Network. National data reports, liver Kaplan-Meier patient survival rates for transplants performed: 1995-2002. Available at: www.optn.org. Accessed July 27, 2006.
64. US Department of Health and Human Services. 2005. Annual report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: transplant data 1995-2004. Rockville (MD): Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation. Tables 9.4a and 9.4b. Available at http://www.hrsa.gov/.
65. Berg C., Gillespie B., Merion R., et al. Adult living donor liver transplantation reduces transplant candidate mortality. [abstract #313]. Am J Transplant 6 s2 (2006) 172
66. Gaglio P., Malireddy S., Levitt B., et al. Increased risk of cholestatic hepatitis C in recipients of grafts from living versus cadaveric liver donors. Liver Transpl 9 (2003) 1028-1035
67. Pan S., Nissen N., Steven C., et al. Comparisons of rejection and hepatitis C recurrence in live donor and deceased donor liver transplantation. [abstract]. Am J Transplant 4 S8 (2004) 295
68. Fahmy A., O'Mahony A., Kaul H., et al. Living donor liver transplantation (LDLT) is safe and effective for hepatitis C recipients. [abstract]. Am J Transplant 4 s8 (2004) 355
69. Vleirberghe H., Troisi R., Colle I., et al. Hepatitis C infection-related liver disease: patterns of recurrence and outcome in cadaveric and living donor liver transplantation in adults. Transplantation 77 (2004) 210-214
70. Gordon F., Pomfret E., Pomposelli J., et al. The severity of recurrent hepatitis C (HCV) in living donor adult liver transplant (LDALT) recipients is the same as cadaver (CAD) recipients. [abstract]. Am J Transplant 4 S8 (2004) 400
71. Bozorgzadeh A., Jain A., Ryan C., et al. Impact of hepatitis C viral infection in primary cadaveric liver allograft versus primary living donor allograft in 100 consecutive liver transplant recipients receiving tacrolimus. Transplantation 77 (2004) 1066-1070
72. Russo M., Galanko J., Beavers K., et al. Patient and graft survival in hepatitis C recipients after adult living donor liver transplantation in the United States. Liver Transpl 10 (2004) 340-346
73. Thuluvath P., and Yoo H. Graft and patient survival after adult live donor liver transplantation compared to a matched cohort who received a deceased donor transplantation. Liver Transpl 10 10 (2004) 1263-1268
74. Shiffman M., Stravitz R., Contos M., et al. Histologic recurrence of chronic hepatitis C virus in patients after living donor and deceased donor liver transplantation. Liver Transpl 10 (2004) 1248-1255
75. Maluf D., Stravitz R., Cotterell A., et al. Adult living donor versus deceased donor liver transplantation: a 6-year single center experience. Am J Transplant 5 (2005) 149-156
76. Humar A., Horn K., Kalls A., et al. Living donor and split-liver transplants in hepatitis C recipients: does liver regeneration in crease the risk for recurrence?. Am J Transplant 5 (2005) 399-405
77. Rodriguez-Luna H., Vargas H., De Petris G., et al. Hepatitis C virus recurrence in living donor liver transplantation vs. cadaveric liver transplantation. [abstract]. Am J Transplant 3 S5 (2003) 160
78. Guo L., Orrego M., Rodriguez-Luna H., et al. Living donor liver transplantation for hepatitis C-related cirrhosis: no difference in histological recurrence when compared to deceased donor liver transplantation recipients. Liver Transpl 12 (2006) 560-565
79. Schiano T., Gutierrez J., Walewski J., et al. Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors. Hepatology 42 (2005) 1420-1428
80. Russo M., and Shrestha R. Editorial: is severe recurrent hepatitis C more common after adult living donor liver transplantation?. Hepatology 40 (2004) 524-526
81. Terrault N.A., Shiffman M.L., Lok A.S., et al. Outcomes in hepatitis C virus-infected recipients of living donor vs. deceased donor liver transplantation. Liver Transpl 13 1 (2007) 122-129
82. Valentin-Gamazo C., Malago M., Karliova M., et al. Experience after the evaluation of 700 potential donors for living donor liver transplantation in a single center. Liver Transpl 10 (2004) 1087-1096
83. Rinella M., Alonso E., Rao S., et al. Body mass index as a predictor or hepatic steatosis in living liver donors. Liver Transpl 7 (2001) 409-414
84. Trotter J.F., Merion R., Everhart J., et al. Outcomes of donor evaluation in adult-to-adult living donor liver transplantation cohort study. Hepatology (2007) in press
85. Ghobrial R., Freise C., Trotter J., et al. Donor morbidity and mortality of adult living donors for liver transplantation. [abstract #145]. Am J Transplant 6 s2 (2006) 115
86. Trotter J., Adam R., Lo C., et al. Documented deaths of hepatic lobe donors for living donor liver transplantation. Liver Transpl 12 (2006) 1-4