Using Q-RT-PCR to measure cyclin D1, TS, TP, DPD, and Her-2/neu as predictors for response, survival, and recurrence in patients with esophageal squamous cell carcinoma following radiochemotherapy

International Journal of Colorectal Disease

Volumn 24, Issue 1, 2009, Pages 69-77

  Brücher, Björn L D M ^a   Keller, Gisela ^b   Werner, Martin ^c   Müller, Ulrike ^d   Lassmann, Silke ^c   Cabras, Antonello Domenico ^e   Fend, Falko ^b   Busch, Raymonde ^b   Stein, Hubert ^f   Allescher, Hans Dieter ^g   Molls, Michael ^b   Siewert, J Rüdiger ^h   Höfler, Heinz ^b,d   Specht, Katja ^b,d  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e NATIONAL CANCER INSTITUTE   (Italy)

^f UNIVERSITY OF SALZBURG   (Austria)

^g Klinikum Garmisch Patenkirchen   (Germany)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cyclin D1; Esophageal carcinoma; Molecular biological markers; Neoadjuvant therapy; Prediction of response

Indexed keywords

CYCLIN D1; DIHYDROPYRIMIDINE DEHYDROGENASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

ADULT; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CONTINUOUS INFUSION; CORRELATION ANALYSIS; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIATION DOSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TREATMENT RESPONSE;

ADULT; AGED; CARCINOMA, SQUAMOUS CELL; CYCLIN D1; DIHYDROURACIL DEHYDROGENASE (NADP); ESOPHAGEAL NEOPLASMS; ESOPHAGECTOMY; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDINE PHOSPHORYLASE; THYMIDYLATE SYNTHASE;

EID: 57049147369     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-008-0562-5     Document Type: Article

References (48)

1. Lehnert T (1999) Multimodal therapy for squamous carcinoma of the oesophagus. Br J Surg 86:727-739
2. Ancona E, Ruol A, Santi S, Merigliano S, Sileni VC, Koussis H, Zaninotto G, Bonavina L, Peracchia A (2001) Only pathologic complete response to neoadjuvant chemotherapy improves significantly the long term survival of patients with resectable esophageal squamous cell carcinoma: Final report of a randomized, controlled trial of preoperative chemotherapy versus surgery alone. Cancer 91:2165-2174
3. Law S, Fok M, Chow S, Chu KM, Wong J (1997) Preoperative chemotherapy versus surgical therapy alone for squamous cell carcinoma of the esophagus: A prospective randomized trial [see comments]. J Thorac Cardiovasc Surg 114:210-217
4. Brücher BLDM, Stein HJ, Zimmermann F, Werner M, Sarbia M, Busch R, Dittler HJ, Molls M, Fink U, Siewert JR (2004) Responders benefit from neoadjuvant radiochemotherapy in esophageal squamous cell carcinoma: results of a prospective phase-II-trial. EJSO 30(9):963-971
5. Brücher BLDM, Weber W, Bauer M, Fink U, Avril N, Stein HJ, Werner M, Zimmermann F, Schwaiger M, Siewert JR (2001) Neoadjuvant therapy in esophageal squamous cell carcinoma: Response evaluation by positron emission tomography. Ann Surg 233(3):300-309
6. Flamen P, Van Cutsem E, Lerut A, Cambier JP, Haustermans K, Bormans G, De Leyn P, Van Raemdonck D, De Wever W, Ectors N, Maes A, Mortelmans L (2002) Positron emission tomography for assessment of the response to induction radiochemotherapy in locally advanced oesophageal cancer. Ann Oncol 13:361-368
7. Wieder HA, Brücher BLDM, Zimmermann F, Becker K, Lordick F, Beer A, Schwaiger M, Fink U, Siewert JR, Stein HJ, Weber WA (2004) Time course of tumor metabolic activity during chemoradiotherapy of esophageal squamous cell carcinoma and response to treatment. J Clin Oncol 22:900-908
8. Brücher BLDM, Becker K, Lordick F, Fink U, Sarbia M, Stein H, Busch R, Zimmermann F, Molls M, Hofler H, Siewert JR (2006) The clinical impact of histopathologic response assessment by residual tumor cell quantification in esophageal squamous cell carcinomas. Cancer 106:2119-2127
9. Langer R, Specht K, Becker K, Ewald P, Bekesch M, Sarbia M, Busch R, Feith M, Stein HJ, Siewert JR, Hofler H (2005) Association of pretherapeutic expression of chemotherapy-related genes with response to neoadjuvant chemotherapy in Barrett carcinoma. Clin Cancer Res 11:7462-7469
10. Napieralski R, Ott K, Kremer M, Specht K, Vogelsang H, Becker K, Muller M, Lordick F, Fink U, Rudiger Siewert J, Hofler H, Keller G (2005) Combined GADD45A and thymidine phosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients. Clin Cancer Res 11:3025-3031
11. Specht K, Richter T, Muller U, Walch A, Hofler MW (2000) Quantitative gene expression analysis in microdissected archival tissue by real-time RT-PCR. J Mol Med 78:B27
12. Specht K, Richter T, Muller U, Walch A, Werner M, Hofler H (2001) Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumor tissue. Am J Pathol 158:419-429
13. Brücher BLDM, Stein HJ, Werner M, Siewert JR (2001) Lymphangiosis carcinomatosa is an independent prognostic factor in primary resected patients with esophageal squamous cell carcinoma. Cancer 92(8):2228-2233
14. Bartels H, Stein HJ, Siewert JR (1998) Preoperative risk analysis and postoperative mortality of oesophagectomy for resectable oesophageal cancer. Br J Surg 85:840-844
15. Miller AB, Hoogstraten B, Staquet M, Winkler A (1981) Reporting results of cancer treatment. Cancer 47:207-214
16. Siewert JR, Hölscher AH, Roder JD, Bartels H (1998) En-bloc esophagectomy in esophageal cancer. Langenbecks Arch Chir 373:367-376
17. Wittekind C, Compton CC, Greene FL, Sobin LH (2002) TNM residual tumor classification revisited. Cancer 94:2511-2516
18. Sobin LH, Wittekind C (2002) TNM classification of malignant tumors, 6th edn. Springer, New York
19. Becker I, Becker KF, Rohrl MH, Minkus G, Schutze K, Hofler H (1996) Single-cell mutation analysis of tumors from stained histologic slides. Lab Invest 75:801-807
20. Gibson UE, Heid CA, Williams PM (1996) A novel method for real time quantitative RT-PCR. Genome Res 6:995-1001
21. Heid CA, Stevens J, Livak KJ, Williams PM (1996) Real time quantitative PCR. Genome Res 6:986-994
22. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. A Am Stat Assoc 75:457-487
23. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1-39
24. Dittler HJ (2002) Surgical endoscopy for staging and the selection of procedure. Chirurg 73:2-8
25. Dittler HJ, Fink U, Siewert GR (1994) Response to chemotherapy in esophageal cancer. Endoscopy 26:769-771
26. Hordijk ML, Kok TC, Wilson JH, Mulder AH (1993) Assessment of response of esophageal carcinoma to induction chemotherapy. Endoscopy 25:592-596
27. Isenberg G, Chak A, Canto MI, Levitan N, Clayman J, Pollack BJ, Sivak MV Jr. (1998) Endoscopic ultrasound in restaging of esophageal cancer after neoadjuvant chemoradiation. Gastrointest Endosc 48:158-163
28. Laterza E, de Manzoni G, Guglielmi A, Rodella L, Tedesco P, Cordiano C (1999) Endoscopic ultrasonography in the staging of esophageal carcinoma after preoperative radiotherapy and chemotherapy. Ann Thorac Surg 67:1466-1469
29. Mallery S, Van Dam J (1999) Interventional endoscopic ultrasonography: current status and future direction. J Clin Gastroenterol 29:297-305
30. Roubein LD, DuBrow R, David C, Lynch P, Fornage B, Ajani J, Roth J, Levin B (1993) Endoscopic ultrasonography in the quantitative assessment of response to chemotherapy in patients with adenocarcinoma of the esophagus and esophagogastric junction. Endoscopy 25:587-591
31. Arnott SJ, Duncan W, Gignoux M, Girling DJ, Hansen HS, Launois B, Nygaard K, Parmar MK, Roussel A, Spiliopoulos G, Stewart LA, Tierney JF, Mei W, Rugang Z (1998) Preoperative radiotherapy in esophageal carcinoma: A meta-analysis using individual patient data (Oesophageal Cancer Collaborative Group). Int J Radiat Oncol Biol Phys 41:579-583
32. Nygaard K, Hagen S, Hansen HS, Hatlevoll R, Hultborn R, Jakobsen A, Mantyla M, Modig H, Munck-Wikland E, Rosengren B et al (1992) Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: A randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The Second Scandinavian Trial in Esophageal Cancer. World J Surg 16:1104-1109, discussion 1110
33. Roth JA, Pass HI, Flanagan MM, Graeber GM, Rosenberg JC, Steinberg S (1988) Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine, and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg 96:242-248
34. Kelsen DP, Ginsberg R, Pajak TF, Sheahan DG, Gunderson L, Mortimer J, Estes N, Haller DG, Ajani J, Kocha W, Minsky BD, Roth JA (1998) Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med 339:1979-1984
35. Group. MRCMUGTC (2000) Medical Research Council (MRC) randomised phase III trial of surgery with or without pre-operative chemotherapy in resectable cancer of the esophagus. Br J Surgery 83:1, (abstract)
36. Siewert JR, Stein HJ, Feith M, Brücher BLDM, Bartels H, Fink U (2001) Histologic tumor type is an independent prognostic parameter in esophageal cancer: Lessons from more than 1,000 consecutive resections at a single center in the western world. Ann Surg 234:360-369
37. Izzo JG, Papadimitrakopoulou VA, Liu DD, den Hollander PL, Babenko IM, Keck J, El-Naggar AK, Shin DM, Lee JJ, Hong WK, Hittelman WN (2003) Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. J Natl Cancer Inst 95:198-205
38. Izzo JG, Papadimitrakopoulou VA, Li XQ, Ibarguen H, Lee JS, Ro JY, El-Naggar A, Hong WK, Hittelman WN (1998) Dysregulated cyclin D1 expression early in head and neck tumorigenesis: In vivo evidence for an association with subsequent gene amplification. Oncogene 17:2313-2322
39. Papadimitrakopoulou VA, Izzo J, Mao L, Keck J, Hamilton D, Shin DM, El-Naggar A, den Hollander P, Liu D, Hittelman WN, Hong WK (2001) Cyclin D1 and p16 alterations in advanced premalignant lesions of the upper aerodigestive tract: Role in response to chemoprevention and cancer development. Clin Cancer Res 7:3127-3134
40. Sarbia M, Gabbert HE (2000) Modern pathology: Prognostic parameters in squamous cell carcinoma of the esophagus: Recent results. Cancer Res 155:15-27
41. Sarbia M, Stahl M, Fink U, Heep H, Dutkowski P, Willers R, Seeber S, Gabbert HE (1999) Prognostic significance of cyclin D1 in esophageal squamous cell carcinoma patients treated with surgery alone or combined therapy modalities. Int J Cancer 84:86-91
42. Harpole DH Jr., Moore MB, Herndon JE 2nd, Aloia T, D'Amico TA, Sporn T, Parr A, Linoila I, Allegra C (2001) The prognostic value of molecular marker analysis in patients treated with trimodality therapy for esophageal cancer. Clin Cancer Res 7:562-569
43. Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L (1995) Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55:1407-1412
44. Kirihara Y, Yamamoto W, Toge T, Nishiyama M (1999) Dihydropyrimidine dehydrogenase, multidrug resistance-associated protein, and thymidylate synthase gene expression levels can predict 5-fluorouracil resistance in human gastrointestinal cancer cells. Int J Oncol 14:551-556
45. Levine EL, Renehan A, Gossiel R, Davidson SE, Roberts SA, Chadwick C, Wilks DP, Potten CS, Hendry JH, Hunter RD et al (1995) Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. Radiother Oncol 37:1-9
46. Nakano T, Oka K, Ishikawa A, Morita S (1998) Immunohistochemical prediction of radiation response and local control in radiation therapy for cervical cancer. Cancer Detect Prev 22:120-128
47. Samejima R, Kitajima Y, Yunotani S, Miyazaki K (1999) Cyclin D1 is a possible predictor of sensitivity to chemoradiotherapy for esophageal squamous cell carcinoma. Anticancer Res 19(16C):5515-5521
48. Toyoda H, Nakamura T, Shinoda M, Suzuku T, Hatooka S, Kobayashi S, Ohashi K, Seto M, Shiku H, Nakamura S (2000) Cyclin D1 expression is useful as a prognostic indicator for advanced esophageal carcinomas, but not for superficial tumors. Dig Dis Sci 45(5):864-869