Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

Clinical and Investigative Medicine

Volumn 31, Issue 6, 2008, Pages

  Thambirajah, Anita A ^a   Sleigh, Kenna ^b   Stiver, H Grant ^b   Chow, Anthony W ^b,c  

^a UNIVERSITY OF VICTORIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90;

ADULT; ARTICLE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TREADMILL EXERCISE; WESTERN BLOTTING;

BIOLOGICAL MARKERS; BLOTTING, WESTERN; CHAPERONIN 60; EXERCISE; EXERCISE TEST; FATIGUE SYNDROME, CHRONIC; FEMALE; HEAT-SHOCK PROTEINS; HSP27 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED;

EID: 57049143268     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Fukuda K, Straus SE, Hickie I et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994; 121: 953-9.
2. Glaser R, Kiecolt-Glaser JK. Stress-associated immune modulation: relevance to viral infections and chronic fatigue syndrome. Am J Med 1998; 105: 35S-42S.
3. Lyall M, Peakman M, Wessely S. A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. J Psychosom Res 2003; 55: 79-90.
4. Plioplys AV, Plioplys S. Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome. Neuropsychobiology 1995; 32: 175-81.
5. McCully KK, Smith S, Rajaei S, Leigh JS, Jr., Natelson BH. Muscle metabolism with blood flow restriction in chronic fatigue syndrome. J Appl Physiol 2004; 96: 871-8.
6. Santoro MG. Heat shock factors and the control of the stress response. Biochem Pharmacol 2000; 59: 55-63.
7. Malago JJ, Koninkx JF, van Dijk JE. The heat shock response and cytoprotection of the intestinal epithelium. Cell Stress Chaperones 2002; 7: 191-9.
8. Rogalla T, Ehrnsperger M, Preville X et al. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem 1999; 274: 18947-56.
9. Arrigo AP, Virot S, Chaufour S et al. Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels. Antioxid Redox Signal 2005; 7: 414-22.
10. Boshoff T, Lombard F, Eiselen R et al. Differential basal synthesis of Hsp70/Hsc70 contributes to interindividual variation in Hsp70/Hsc70 inducibility. Cell Mol Life Sci 2000; 57: 1317-25.
11. Scheibel T, Buchner J. The Hsp90 complex - a super-chaperone machine as a novel drug target. Biochem Pharmacol 1998; 56: 675-82.
12. Fehrenbach E, Niess AM, Schlotz E et al. Transcriptional and translational regulation of heat shock proteins in leukocytes of endurance runners. J Appl Physiol 2000; 89: 704-10.
13. Whitham M, Halson SL, Lancaster GI et al. Leukocyte heat shock protein expression before and after intensified training. Int J Sports Med 2004; 25: 522-7.
14. Komaroff AL, Buchwald D. Symptoms and signs of chronic fatigue syndrome. Rev Infect Dis 1991; 13 Suppl 1:S8-11.: S8-11.
15. Strzelczyk TA, Cusick DA, Pfeifer PB, Bondmass MD, Quigg RJ. Value of the Bruce protocol to determine peak exercise oxygen consumption in patients evaluated for cardiac transplantation. Am Heart J 2001; 142: 466-75.
16. See RH, Kum WW, Chang AH, Goh SH, Chow AW. Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes. Infect Immun 1992; 60: 2612-8.
17. Kerr JR, Burke B, Petty R et al. Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: a detailed analysis of gene networks and clinical phenotypes. J Clin Pathol 2008; 61: 730-9.
18. Jammes Y, Steinberg JG, Mambrini O, Bregeon F, Delliaux S. Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise. J Intern Med 2005; 257: 299-310.
19. Richards RS, Roberts TK, McGregor NR, Dunstan RH, Butt HL. Blood parameters indicative of oxidative stress are associated with symptom expression in chronic fatigue syndrome. Redox Rep 2000;5:35-41.
20. Fulcher KY, White PD. Strength and physiological response to exercise in patients with chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 2000;69:302-7.
21. Vecchiet J, Cipollone F, Falasca K et al. Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 2003;335:151-4.
22. Koh TJ. Do small heat shock proteins protect skeletal muscle from injury? Exerc Sport Sci Rev 2002;30:117-21.
23. Lawler JM, Kwak HB, Song W, Parker JL. Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion. Am J Physiol Regul Integr Comp Physiol 2006;291:R1756-R1763.
24. Arrigo AP. Hsp27: novel regulator of intracellular redox state. IUBMB Life 2001;52:303-7.
25. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003;304:505-12.
26. Arrigo AP, Firdaus WJ, Mellier G et al. Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression. Methods 2005;35:126-38.