Seven genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis: A detailed analysis of gene networks and clinical phenotypes

Journal of Clinical Pathology

Volumn 61, Issue 6, 2008, Pages 730-739

  Kerr, J R ^a   Burke, B ^a   Petty, R ^a   Gough, J ^a   Fear, D ^b   Mattey, D L ^c   Axford, J S ^a   Dalgleish, A G ^a   Nutt, D J ^d  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Staffordshire Rheumatology Centre   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; ATLIZUMAB; CERTOLIZUMAB PEGOL; ETANERCEPT; GOLIMUMAB; INFLIXIMAB; LONAFARNIB; TIPIFARNIB;

ADULT; ARTICLE; CHRONIC FATIGUE SYNDROME; CLINICAL FEATURE; CONTROLLED STUDY; DRUG TARGETING; FEMALE; GENE EXPRESSION; GENE INTERACTION; GENE TARGETING; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; UNINDEXED SEQUENCE;

ADULT; ANXIETY; CLUSTER ANALYSIS; DEPRESSION; FATIGUE SYNDROME, CHRONIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; SYNDROME;

EID: 45549102593     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2007.053553     Document Type: Article

References (36)

1. Fukuda K, Straus SE, Hickie I, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994;121:953- 9.
2. CFS/ME Working Group. A report of the CFS/ME Working Group. Department of Health, 2002.
3. Papanicolaou DA, Amsterdam JD, Levine S, et al. Neuroendocrine aspects of chronic fatigue syndrome. Neuroimmunomodulation 2004;11:65-74.
4. Komaroff AL, Buchwald D. Chronic fatigue syndrome: an update. Annu Rev Med 1998;49:1-13.
5. Devanur LD, Kerr JR. Chronic fatigue syndrome. J Clin Virol 2006;37:139-50.
6. Kerr JR, Petty R, Burke B, et al. Differentially expressed genes in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) patients reveal seven subtypes with distinct clinical phenotypes. J Infect Dis 2008;197:1-4.
7. Reeves WC, Lloyd A, Vernon SD, et al. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res 2003;3:25.
8. Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res 1993;37:147-53.
9. Joyce E, Blumenthal S, Wessely S. Memory, attention, and executive function in chronic fatigue syndrome. J Neurol Neurosurg Psychiatry 1996;60:495-503.
10. Sturn A, Quackenbush J, Trajanoski Z. Genesis: cluster analysis of microarray data. Bioinformatics 2002;18:207-8.
11. Eisen MB, Spellman PT, Brown PO, et al. Cluster analysis and display of genomewide expression patterns. Proc Natl Acad Sci USA 1998;95:14863-8.
12. Jason LA, Corradi K, Torres-Harding S, et al. Chronic fatigue syndrome: the need for subtypes. Neuropsychol Rev 2005;15:29-58.
13. Janal MN, Ciccone DS, Natelson BH. Sub-typing CFS patients on the basis of "minor" symptoms. Biol Psychol 2006;73:124-31.
14. Chia JK. The role of enterovirus in chronic fatigue syndrome J Clin Pathol 2005;58:1126-32.
15. Chia JK, Chia AY. Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach. J Clin Pathol 2008;61:43-8.
16. Whistler T, Unger ER, Nisenbaum R, et al. Integration of gene expression, clinical, and epidemiologic data to characterize chronic fatigue syndrome. J Transl Med 2003;1:10-8.
17. Byrd MP, Zamora M, Lloyd RE. Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons. Mol Cell Biol 2002;22:4499-511.
18. Glaser R, Padgett DA, Litsky ML, et al. Stress-associated changes in the steady-state expression of latent Epstein-Barr virus: implications for chronic fatigue syndrome and cancer. Brain Behav Immun 2005;19:91-103.
19. Sairenji T, Yamanishi K, Tachibana Y, et al. Antibody responses to Epstein-Barr virus, human herpesvirus 6 and human herpesvirus 7 in patients with chronic fatigue syndrome. Intervirology 1995;38:269-73.
20. Birkenbach M, Josefsen K, Yalamanchili R, et al. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J Virol 2003;67:2209-20.
21. Kogelnik AM, Loomis K, Hoegh-Petersen M, et al. Use of valganciclovir in patients with elevated antibody titers against human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue. J Clin Virol 2006;37(Suppl 1):S33-8.
22. Kaushik N, Fear D, Richards SC, et al. Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome. J Clin Pathol 2005;58:826-32.
23. Glynn P. NTE: one target protein for different toxic syndromes with distinct mechanisms? Bioessays 2003;25:742-5.
24. Tahmaz N, Soutar A, Cherrie JW. Chronic fatigue and organophosphate pesticides in sheep farming: a retrospective study amongst people reporting to a UK pharmacovigilance scheme. Ann Occup Hyg 2003;47:261-7.
25. Proctor SP, Heaton KJ, Heeren T, et al. Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans. Neurotoxicology 2006;27:931-9.
26. He JQ, Shumansky K, Zhang X, et al. Polymorphisms of interleukin-10 and its receptor and lung function in COPD. Eur Respir J 2007;29:1120-6.
27. Nieters A, Beckmann L, Deeg E, et al. Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk. Genes Immun 2006;7:615-24.
28. Qi ZM, Wang J, Sun ZR, et al. Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain II10ra and its association with the autoimmune phenotype. Immunogenetics 2005;57:697-702.
29. Saito T, Ji G, Shinzawa H, et al. Genetic variations in humans associated with differences in the course of hepatitis C. Biochem Biophys Res Commun 2004;317:335-41.
30. Heggarty S, Sawcer S, Hawkins S, et al. A genome wide scan for association with multiple sclerosis in a N. Irish case control population. J Neuroimmunol 2003;143:93-6.
31. Levine PH, Fears TR, Cummings P, et al. Cancer and a fatiguing illness in Northern Nevada - a causal hypothesis. Ann Epidemiol 1998;8:245-9.
32. Levine PH, Atherton M, Fears T, et al. An approach to studies of cancer subsequent to clusters of chronic fatigue syndrome: use of data from the Nevada State Cancer Registry. Clin Infect Dis 1994;18(Suppl 1):S49-53.
33. Grans H, Nilsson M, Dahlman-Wright K, et al. Reduced levels of oestrogen receptor beta mRNA in Swedish patients with chronic fatigue syndrome. J Clin Pathol 2007;60:195-8.
34. Grans H, Nilsson P, Evengard B. Gene expression profiling in the chronic fatigue syndrome. J Intern Med 2005;258:388-90.
35. Lang TJ. Estrogen as an immunomodulator. Clin Immunol 2004;113:224-30.
36. Vallings R. American Association for Chronic Fatigue Syndrome (AACFS), 5th international research, clinical and patient conference, 25-29 January 2001, Seattle, USA. http://www.cfs-news.org/aacfs-01.htm (accessed 6 February 2008).