Association of Insulin Resistance with Alanine Aminotransferase Activity in Patients with Nonalcoholic Fatty Liver Disease

Tzu Chi Medical Journal

Volumn 20, Issue 4, 2008, Pages 275-279

  Wang, Chia Chi ^a   Wu, Wai Wah ^a   Hsu, Ching Sheng ^a   Wang, Pin Chao ^a   Lin, Hans Hsienhong ^a   Kao, Jia Horng ^b  

^a BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^b Department of Medical Research ^*  (Taiwan)

Author keywords

Alanine aminotransferase; Insulin resistance; Non alcoholic fatty liver disease

Indexed keywords

EID: 57049115970     PISSN: 10163190     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1016-3190(08)60050-6     Document Type: Article

References (30)

1. Chitturi S., Farrell G.C., and George J. Non-alcoholic steatohepatitis in the Asia-Pacific region: future shock?. J Gastroenterol Hepatol 19 (2004) 368-374
2. Matteoni C.A., Younossi Z.M., Gramlich T., Boparai N., Liu Y.C., and McCullough A.J. Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116 (1999) 1413-1419
3. Marchesini G., Brizi M., Bianchi G., et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50 (2001) 1844-1850
4. Marchesini G., Bugianesi E., Forlani G., et al. Non-alcoholic fatty liver, steatohepatitis and the metabolic syndrome. Hepatology 37 (2003) 917-923
5. Clark J.M., and Diehl A.M. Hepatic steatosis and type 2 diabetes mellitus. Curr Diab Rep 2 (2002) 210-215
6. Brea A., Mosquera D., Martin E., Arizti A., Cordero J.L., and Ros E. Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case-control study. Arterioscler Thromb Vasc Biol 25 (2005) 1045-1050
7. Day C.P., and James O.F. Steatohepatitis: a tale of two "hits"?. Gastroenterology 114 (1998) 842-845
8. Scheig R. Evaluation of tests used to screen patients with liver disorders. Prim Care 23 (1996) 551-560
9. Hanley A.J., Williams K., Festa A., et al. Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study. Diabetes 53 (2004) 2623-2632
10. Hanley A.J., Williams K., Festa A., Wagenknecht L.E., D'Agostino RB J., and Haffner S.M. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes 54 (2005) 3140-3147
11. Farrell G.C., Chitturi S., Lau G.K., and Sollano JD; Asia-Pacific Working Party on N. Guideline for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol 22 (2007) 775-777
12. Bonora E., Targher G., Alberiche M., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23 (2000) 57-63
13. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 137 (2002) 1-10
14. Osawa H., and Mori Y. Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical amplitudes. J Clin Ultrasound 24 (1986) 25-29
15. Saadeh S., Younossi Z.M., Remer E.M., et al. The utility of radiographic imaging in nonalcoholic fatty liver disease. Gastroenterology 123 (2002) 745-750
16. Marchesini G., Avagnina S., Barantani E.G., et al. Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are associated with insulin resistance and the metabolic syndrome. J Endocrinol Invest 28 (2005) 333-339
17. Chung R.T., Casson D.R., Murray G., Song S., Grinspoon S., and Hadigan C. Alanine aminotransferase levels predict insulin resistance in HIV lipodystrophy. J Acquir Immune Defic Syndr 34 (2003) 534-536
18. de Luis D.A., Aller R., Izaola O., Sagrado M.G., Con de R., and Bellido D. Influence of insulin resistance and adipocytokines on elevated serum aminotransferase in obese patients. Arch Med Res 39 (2008) 110-114
19. Dessein P.H., Woodiwiss A.J., Joffe B.I., and Norton G.R. Aminotransferases are associated with insulin resistance and atherosclerosis in rheumatoid arthritis. BMC Cardiovasc Disord 2007;7:31. 20. Shen YH, Yang WS, Lee TH, Lee LT, Chen CY, Huang KC. Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults. Obes Res 13 (2005) 1238-1245
20. Belfort R., Harrison S.A., Brown K., et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med 355 (2006) 2297-2307
21. Sheth S.G., Gordon F.D., and Chopra S. Nonalcoholic steatohepatitis. Ann Intern Med 126 (1997) 137-145
22. Su C.C., Wang K., Hsia T.L., Chen C.S., and Tung T.H. Association of nonalcoholic fatty liver disease with abnormal aminotransferase and postprandial hyperglycemia. J Clin Gastroenterol 40 (2006) 551-554
23. Hanley A.J., Wagenknecht L.E., Festa A., D'Agostino RB J., and Haffner S.M. Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Diabetes Care 30 (2007) 1819-1827
24. Schindhelm R.K., Dekker J.M., Nijpels G., et al. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis 191 (2007) 391-396
25. Chen C.H., Huang M.H., Yang J.C., et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J Clin Gastroenterol 40 (2006) 745-752
26. The IDF Consensus Worldwide Definition of the Metabolic Syndrome (2006), International Diabetes Federation
27. Oh S.Y., Cho Y.K., Kang M.S., et al. The association between increased alanine aminotransferase activity and metabolic factors in nonalcoholic fatty liver disease. Metabolism 55 (2006) 1604-1609
28. Salazar M.R., Carbajal H.A., Curciarello J.O., Aizpurua M., Adrover R.E., and Riondet B. Alanine-aminotransferase: an early marker for insulin resistance?. Medicina (B Aires) 67 (2007) 125-130
29. Fraser A., Ebrahim S., Smith G.D., and Lawlor D.A. A comparison of association of alanine aminotransferase and gammaglutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes. Hepatology 46 (2007) 158-165
30. Mittendorfer B. Insulin resistance: sex matter. Curr Opin Clin Nutr Metab Care 8 (2005) 367-372