Alanine Aminotransferase Levels Predict Insulin Resistance in HIV Lipodystrophy [2]

Journal of Acquired Immune Deficiency Syndromes

Volumn 34, Issue 5, 2003, Pages 534-536

  Chung, Raymond T ^a   Casson, Deborah R ^a   Murray, Gisela ^a   Song, Sunbin ^a   Grinspoon, Steven ^a   Hadigan, Colleen ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; GLUCOSE; PROTEINASE INHIBITOR; VIRUS RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; BODY MASS; COMORBIDITY; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN RESISTANCE; LETTER; LIPODYSTROPHY; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; VIRUS HEPATITIS; VIRUS INFECTION;

ADIPOSE TISSUE; ADULT; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY CONSTITUTION; BODY MASS INDEX; HIV-ASSOCIATED LIPODYSTROPHY SYNDROME; HUMANS; INSULIN; INSULIN RESISTANCE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS;

EID: 0345490961     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200312150-00015     Document Type: Letter

References (8)

1. Hadigan C, Meigs JB, Corcoran C, et al. Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy. Clin Infect Dis. 2001;32:130-139.
2. Mehta SH, Brancati FL, Sulkowski MS, et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med. 2000;133:592-599.
3. Ruhl CE, Everhart JE. Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States. Gastroenterology. 2003;124: 71-79.
4. Duong M, Petit JM, Piroth L, et al. Association between insulin resistance and hepatitis C virus chronic infection in HIV-hepatitis C virus-coinfected patients undergoing antiretroviral therapy. J Acquir Immune Defic Syndr. 2001; 27:245-250.
5. Vozarova B, Stefan N, Lindsay RS, et al. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002;51:1889-1895.
6. Chitturi S, Abeygunasekera S, Farrell GC, et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002; 35:373-379.
7. Sutinen J, Hakkinen AM, Westerbacka J, et al. Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS. 2002;16: 2183-2193.
8. Riddle TM, Kuhel DG, Woollett LA, et al. HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus. J Biol Chem. 2001;276:37514-37519.