Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Sebastian, Korff ^a   Woerner, Stefan M ^a   Yuan, Yan P ^b   Bork, Peer ^b,c   von Knebel Doeberitz, Magnus ^a   Gebert, Johannes ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE N21; PROTEIN TYROSINE PHOSPHATASE N5; PROTEIN TYROSINE PHOSPHATASE RECEPTOR S; UNCLASSIFIED DRUG; MICROSATELLITE DNA;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; COLORECTAL ADENOMA; COLORECTAL TUMOR; CONTROLLED STUDY; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; NUCLEOTIDE REPEAT; BIOLOGY; CELL LINE; CELL TRANSFORMATION; CHEMISTRY; GENETICS; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATHOLOGY;

CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; DNA MUTATIONAL ANALYSIS; FRAMESHIFT MUTATION; HUMANS; MICROSATELLITE INSTABILITY; MICROSATELLITE REPEATS; OPEN READING FRAMES; PROTEIN TYROSINE PHOSPHATASES;

EID: 57049111432     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-329     Document Type: Article

References (51)

1. Remvikos Y Tominaga O Hammel P Laurent-Puig P Salmon RJ Dutrillaux B et al. Increased p53 protein content of colorectal tumours correlates with poor survival Br J Cancer 1992, 66:758-764. 1419618
2. Jen J Kim H Piantadosi S Liu ZF Levitt RC et al. Sistonen P Allelic loss of chromosome 18q and prognosis in colorectal cancer N Engl J Med 1994, 331:213-221. 8015568
3. Laurent-Puig P Olschwang S Delattre O Remvikos Y Asselain B Melot T et al. Survival and acquired genetic alterations in colorectal cancer Gastroenterology 1992, 102:1136-1141. 1551522
4. Imai K Yamamoto H Carcinogenesis and microsatellite instability: The interrelationship between genetics and epigenetics Carcinogenesis 2008, 29:673-680. 17942460
5. Lynch HT Lynch JF Lynch PM Attard T Hereditary colorectal cancer syndromes: Molecular genetics, genetic counseling, diagnosis and management Fam Cancer 2008, 7:27-39. 17999161
6. Ionov Y Peinado MA Malkhosyan S Shibata D Perucho M Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis Nature 1993, 363:558-561. 8505985
7. Thibodeau SN Bren G Schaid D Microsatellite instability in cancer of the proximal colon Science 1993, 260:816-819. 8484122
8. Linnebacher M Gebert J Rudy W Woerner S Yuan YP Bork P et al. Frameshift peptide-derived T-cell epitopes: A source of novel tumor-specific antigens Int J Cancer 2001, 93:6-11. 11391614
9. Saeterdal I Bjorheim J Lislerud K Gjertsen MK Bukholm IK Olsen OC et al. Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer Proc Natl Acad Sci USA 2001, 98:13255-13260. 60857 11687624
10. Ripberger E Linnebacher M Schwitalle Y Gebert J von Knebel Doeberitz M Identification of an HLA-A0201-restricted CTL epitope generated by a tumor-specific frameshift mutation in a coding microsatellite of the OGT gene J Clin Immunol 2003, 23:415-423. 14601650
11. Schwitalle Y Linnebacher M Ripberger E Gebert J von Knebel Doeberitz M Immunogenic peptides generated by frameshift mutations in DNA mismatch repair-deficient cancer cells Cancer Immun 2004, 4:14. 15563124
12. Duval A Iacopetta B Ranzani GN Lothe RA Thomas G Hamelin R Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability Oncogene 1999, 18:6806-6809. 10597289
13. Kim NG Rhee H Li LS Kim H Lee JS Kim JH et al. Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability Oncogene 2002, 21:5081-5087. 12140758
14. Mori Y Yin J Rashid A Leggett BA Young J Simms L et al. Instabilotyping: comprehensive identification of frameshift mutations caused by coding region microsatellite instability Cancer Res 2001, 61:6046-6049. 11507051
15. Woerner SM Gebert J Yuan YP Sutter C Ridder R Bork P et al. Systematic identification of genes with coding microsatellites mutated in DNA mismatch repair-deficient cancer cells Int J Cancer 2001, 93:12-19. 11391615
16. Woerner SM Benner A Sutter C Schiller M Yuan YP Keller G et al. Pathogenesis of DNA repair-deficient cancers: A statistical meta-analysis of putative Real Common Target genes Oncogene 2003, 22:2226-2235. 12700659
17. Grady WM Rajput A Myeroff L Liu DF Kwon K Willis J et al. Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas Cancer Res 1998, 58:3101-3104. 9679977
18. Hempen PM Zhang L Bansal RK Iacobuzio-Donahue CA Murphy KM Maitra A et al. Evidence of Selection for Clones Having Genetic Inactivation of the Activin A Type II Receptor (ACVR2) Gene in Gastrointestinal Cancers Cancer Res 2003, 63:994-999. 12615714
19. Ionov Y Yamamoto H Krajewski S Reed JC Perucho M Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution Proc Natl Acad Sci USA 2000, 97:10872-10877. 27116 10984511
20. Cuilliere-Dartigues P El-Bchiri J Krimi A Buhard O Fontanges P Flejou JF et al. TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription Oncogene 2006, 25:4441-4448. 16547505
21. Buckowitz A Knaebel HP Benner A Blaker H Gebert J Kienle P et al. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases Br J Cancer 2005, 92:1746-1753. 15856045
22. Smyrk TC Watson P Kaul K Lynch HT Tumor-infiltrating lymphocytes are a marker for microsatellite instability in colorectal carcinoma Cancer 2001, 91:2417-2422. 11413533
23. Gryfe R Kim H Hsieh ET Aronson MD Holowaty EJ Bull SB et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer N Engl J Med 2000, 342:69-77. 10631274
24. Samowitz WS Holden JA Curtin K Edwards SL Walker AR Lin HA et al. Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer Am J Pathol 2001, 158:1517-1524. 1891913 11290569
25. Carethers JM Smith EJ Behling CA Nguyen L Tajima A Doctolero RT et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer Gastroenterology 2004, 126:394-401. 14762775
26. Ribic CM Sargent DJ Moore MJ Thibodeau SN French AJ Goldberg RM Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer N Engl J Med 2003, 349:247-257. 12867608
27. Tonks NK Neel BG Combinatorial control of the specificity of protein tyrosine phosphatases Curr Opin Cell Biol 2001, 13:182-195. 11248552
28. Blume-Jensen P Hunter T Oncogenic kinase signalling Nature 2001, 411:355-365. 11357143
29. Yu CC Mamchak AA DeFranco AL Signaling mutations and autoimmunity Curr Dir Autoimmun 2003, 6:61-88. 12408047
30. Tabiti K Smith DR Goh HS Pallen CJ Increased mRNA expression of the receptor-like protein tyrosine phosphatase alpha in late stage colon carcinomas Cancer Lett 1995, 93:239-248. 7621435
31. Seo Y Matozaki T Tsuda M Hayashi Y Itoh H Kasuga M Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers Biochem Biophys Res Commun 1997, 231:705-711. 9070877
32. Saha S Bardelli A Buckhaults P Velculescu VE Rago C St CB et al. A phosphatase associated with metastasis of colorectal cancer Science 2001, 294:1343-1346. 11598267
33. Dunican DS McWilliam P Tighe O Parle-McDermott A Croke DT Gene expression differences between the microsatellite instability (MIN) and chromosomal instability (CIN) phenotypes in colorectal cancer revealed by high-density cDNA array hybridization Oncogene 2002, 21:3253-3257. 12082642
34. Mori Y Sato F Selaru FM Olaru A Perry K Kimos MC et al. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers Cancer Res 2002, 62:3641-3645. 12097267
35. Bentires-Alj M Paez JG David FS Keilhack H Halmos B Naoki K et al. Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia Cancer Res 2004, 64:8816-8820. 15604238
36. Ruivenkamp CA van WT Zanon C Stassen AP Vlcek C Csikos T et al. Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers Nat Genet 2002, 31:295-300. 12089527
37. Wang Z Shen D Parsons DW Bardelli A Sager J Szabo S et al. Mutational analysis of the tyrosine phosphatome in colorectal cancers Science 2004, 304:1164-1166. 15155950
38. Sutter C Gebert J Bischoff P Herfarth C von Knebel Doeberitz M Molecular screening of potential HNPCC patients using a multiplex microsatellite PCR system Mol Cell Probes 1999, 13:157-165. 10208807
39. Boland CR Thibodeau SN Hamilton SR Sidransky D Eshleman JR Burt RW et al. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer Cancer Res 1998, 58:5248-5257. 9823339
40. Woerner SM Kloor M Mueller A Rueschoff J Friedrichs N Buettner R Microsatellite instability of selective target genes in HNPCC-associated colon adenomas Oncogene 2005, 24:2525-2535. 15735733
41. Tom BH Rutzky LP Jakstys MM Oyasu R Kaye CI Kahan BD Human colonic adenocarcinoma cells. I. Establishment and description of a new line In Vitro 1976, 12:180-191. 1262041
42. Tom BH Rutzky LP Oyasu R Tomita JT Goldenberg DM Kahan BD Human colon adenocarcinoma cells. II. Tumorigenic and organoid expression in vivo and in vitro J Natl Cancer Inst 1977, 58:1507-1512. 857038
43. Vilkki S Launonen V Karhu A Sistonen P Vastrik I Aaltonen LA Screening for microsatellite instability target genes in colorectal cancers J Med Genet 2002, 39:785-789. 1735006 12414815
44. Yamamoto H Gil J Schwartz S Jr Perucho M Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype Cell Death Differ 2000, 7:238-239. 10819600
45. Tonks NK Protein tyrosine phosphatases: From genes, to function, to disease Nat Rev Mol Cell Biol 2006, 7:833-846. 17057753
46. Fodde R Smits R Cancer biology. A matter of dosage Science 2002, 298:761-7631. 2399571
47. Santarosa M Ashworth A Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way Biochim Biophys Acta 2004, 1654:105-122. 15172699
48. Forrest AR Taylor DF Crowe ML Chalk AM Waddell NJ Kolle G Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases Genome Biol 2006, 7:R5. 1431701 16507138
49. Jui HY Tseng RJ Wen X Fang HI Huang LM Chen KY et al. Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases J Biol Chem 2000, 275:41124-41132. 11013262
50. Cardone L Carlucci A Affaitati A Livigni A DeCristofaro T Garbi C Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling Mol Cell Biol 2004, 24:4613-4626. 416429 15143158
51. Yao H Song E Chen J Hamar P Expression of FAP-1 by human colon adenocarcinoma: Implication for resistance against Fas-mediated apoptosis in cancer Br J Cancer 2004, 91:1718-1725. 15494722