Reduction of charge-modified LDL by statin therapy in patients with CHD or CHD risk factors and elevated LDL-C levels: The SPECIAL Study

Atherosclerosis

Volumn 201, Issue 2, 2008, Pages 353-359

  Zhang, Bo ^a   Miura, Shin ichiro ^a   Yanagi, Daizaburo ^a   Noda, Keita ^a   Nishikawa, Hiroaki ^a   Matsunaga, Akira ^a   Shirai, Kazuyuki ^a   Iwata, Atsushi ^a   Yoshinaga, Kazuhiko ^b   Adachi, Hisashi ^c   Imaizumi, Tsutomu ^c   Saku, Keijiro ^a  

^a FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Capillary isotachophoresis; Coronary heart disease (CHD); Electronegative LDL; Hypercholesterolemia; Statins

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; C REACTIVE PROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; PRAVASTATIN; SIMVASTATIN;

ADULT; AGED; ARTICLE; ATHEROGENESIS; CAPILLARY ISOTACHOPHORESIS; CHOLESTEROL BLOOD LEVEL; DISEASE MARKER; DRUG DOSE INCREASE; FEMALE; HUMAN; INFLAMMATION; ISCHEMIC HEART DISEASE; ISOTACHOPHORESIS; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; ANTICHOLESTEREMIC AGENTS; C-REACTIVE PROTEIN; CHOLESTEROL, LDL; CORONARY DISEASE; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; PRAVASTATIN; RISK FACTORS; SIMVASTATIN; TREATMENT OUTCOME; TRIGLYCERIDES;

EID: 56949098061     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.02.024     Document Type: Article

References (22)

1. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection evaluation and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
2. Sanchez-Quesada J.L., Benitez S., and Ordonez-Llanos J. Electronegative low-density lipoprotein. Curr Opin Lipidol 15 (2004) 329-335
3. Tomasik A., Jachec W., Skrzep-Poloczek B., et al. Circulating electronegatively charged low-density lipoprotein in patients with angiographically documented coronary artery disease. Scand J Clin Lab Invest 63 (2003) 259-265
4. Sanchez-Quesada J.L., Perez A., Caixas A., et al. Effect of glycemic optimization on electronegative low-density lipoprotein in diabetes: relation to nonenzymatic glycosylation and oxidative modification. J Clin Endocrinol Metab 86 (2001) 3243-3249
5. Sanchez-Quesada J.L., Benitez S., Otal C., et al. Density distribution of electronegative LDL in normolipidemic and hyperlipidemic subjects. J Lipid Res 43 (2002) 699-705
6. De Castellarnau C., Sanchez-Quesada J.L., Benitez S., et al. Electronegative LDL from normolipidemic subjects induces IL-8 and monocyte chemotactic protein secretion by human endothelial cells. Arterioscler Thromb Vasc Biol 20 (2000) 2281-2287
7. Sanchez-Quesada J.L., Camacho M., Anton R., et al. Electronegative LDL of FH subjects: chemical characterization and induction of chemokine release from human endothelial cells. Atherosclerosis 166 (2003) 261-270
8. Benitez S., Villegas V., Bancells C., et al. Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine content. Biochemistry 43 (2004) 15863-15872
9. Sanchez-Quesada J.L., Otal-Entraigas C., Franco M., et al. Effect of simvastatin treatment on the electronegative low-density lipoprotein present in patients with heterozygous familial hypercholesterolemia. Am J Cardiol 84 (1999) 655-659
10. Böttcher A., Schlosser J., Kronenberg F., et al. Preparative free-solution isotachophoresis for separation of human plasma lipoproteins: apolipoprotein and lipid composition of HDL subfractions. J Lipid Res 41 (2000) 905-915
11. Schmitz G., Mollers C., and Richter V. Analytical capillary isotachophoresis of human serum lipoproteins. Electrophoresis 18 (1997) 1807-1813
12. Zhang B., Böttcher A., Imaizumi S., et al. Relation between charge-based apolipoprotein B-containing lipoprotein subfractions and remnant-like particle cholesterol levels. Atherosclerosis 191 (2007) 153-161
13. Zhang B., Kaneshi T., Ohta T., and Saku K. Relation between insulin resistance and fast-migrating LDL subfraction as characterized by capillary isotachophoresis. J Lipid Res 46 (2005) 2265-2277
14. Zhang B., Uehara Y., Hida S., et al. Effects of apoA-I/phosphatidylcholine discs on charge-based LDL subfractions as characterized by capillary isotachophoresis. J Lipid Res 48 (2007) 1175-1189
15. Zhang B., Maeda N., Okada K., et al. Association between fast-migrating low-density lipoprotein subfraction as characterized by capillary isotachophoresis and intima-media thickness of carotid artery. Atherosclerosis 187 (2006) 205-212
16. Zhang B., Matsunaga A., Saku K., Nakano S., and Yamada T. Associations among plasma lipoprotein subfractions as characterized by analytical capillary isotachophoresis, apolipoprotein E phenotype, Alzheimer disease, and mild cognitive impairment. Arterioscler Thromb Vasc Biol 24 (2004) e144-e146
17. Hirano T., Ito Y., Koba S., et al. Clinical significance of small dense low-density lipoprotein cholesterol levels determined by the simple precipitation method. Arterioscler Thromb Vasc Biol 24 (2004) 558-563
18. Zhang B., Fan P., Shimoji E., et al. Modulating effects of cholesterol feeding and simvastatin treatment on platelet-activating factor acetylhydrolase activity and lysophosphatidylcholine concentration. Atherosclerosis 186 (2006) 291-301
19. Benitez S., Camacho M., Bancells C., et al. Wide proinflammatory effect of electronegative low-density lipoprotein on human endothelial cells assayed by a protein array. Biochim Biophys Acta 1761 (2006) 1014-1021
20. de Castellarnau C., Bancells C., Benitez S., et al. Atherogenic and inflammatory profile of human arterial endothelial cells (HUAEC) in response to LDL subfractions. Clin Chim Acta 376 (2007) 233-236
21. Benitez S., Ordonez-Llanos J., Franco M., et al. Effect of simvastatin in familial hypercholesterolemia on the affinity of electronegative low-density lipoprotein subfractions to the low-density lipoprotein receptor. Am J Cardiol 93 (2004) 414-420
22. Gaubatz J.W., Gillard B.K., Massey J.B., et al. Dynamics of dense electronegative low density lipoproteins and their preferential association with lipoprotein phospholipase A(2). J Lipid Res 48 (2007) 348-357