2,3,5-Substituted tetrahydrofurans: COX-2 inhibitory activities of 5-hydroxymethyl-/carboxyl-2,3-diaryl-tetrahydro-furan-3-ols

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2792-2799

  Singh, Palwinder ^a   Mittal, Anu ^a   Kaur, Satwinderjeet ^a   Kumar, Subodh ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

Author keywords

2,3 Diaryl tetrahydrofurans; COX 2 inhibitors; Cyclooxygenase 2; In vitro studies; QSAR

Indexed keywords

4 FLUOROPHENYL DERIVATIVE; 4 HYDROXY 4,5 DIPHENYLTETRAHYDROFURAN 2 CARBOXYLIC ACID; 4 METHOXYPHENYL DERIVATIVE; 5 HYDROXYMETHYL 2,3 DIARYLTETRAHYDROFURAN 3 OL DERIVATIVE; CARBOXYL 2,3 DIARYLTETRAHYDROFURAN 3 OL DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ROFECOXIB; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOLECULAR MODEL; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROSTATE CANCER; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; FURANS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

EID: 56949092138     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.12.017     Document Type: Article

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35. log P and total polar surface area were calculated using molinspiration (www.molinspiration.com). Other descriptors were taken from BioMed Cache 7.5.0.85.