Lack of sex differences in the IGF-IGFBP response to ultra endurance exercise

Scandinavian Journal of Medicine and Science in Sports

Volumn 18, Issue 6, 2008, Pages 706-714

  Berg, U ^a,b   Enqvist, J K ^c   Mattsson, C M ^b,c   Carlsson Skwirut, C ^a   Sundberg, C J ^b   Ekblom, B ^c   Bang, P ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH SCHOOL OF SPORT AND HEALTH SCIENCES   (Sweden)

Author keywords

Adventure race; Catabolism; IGFBP 3 fragmentation; Testosterone; Women

Indexed keywords

ESTROGEN; SOMATOMEDIN BINDING PROTEIN; TESTOSTERONE;

ADULT; ARTICLE; BLOOD; COMPARATIVE STUDY; EXERCISE; FEMALE; HUMAN; MALE; METABOLISM; PHYSIOLOGY; RUNNING; SEX DIFFERENCE; SWEDEN;

ADULT; ESTROGENS; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; MALE; PHYSICAL EXERTION; RUNNING; SEX FACTORS; SWEDEN; TESTOSTERONE;

EID: 56849112481     PISSN: 09057188     EISSN: 16000838     Source Type: Journal    
DOI: 10.1111/j.1600-0838.2007.00758.x     Document Type: Article

References (55)

1. Bang P, Eriksson U, Sara V, Wivall IL, Hall K. Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays: improvement of determinations in acid ethanol extracts by the use of truncated IGF-I as radioligand. Acta Endocrinol (Copenhagen) 1991 : 124 : 620 629.
2. Bang P, Nygren J, Carlsson-Skwirut C, Thorell A, Ljungqvist O. Postoperative induction of insulin-like growth factor binding protein-3 proteolytic activity: relation to insulin and insulin sensitivity. J Clin Endocrinol Metab 1998 : 83 : 2509 2515.
3. Bar RS, Clemmons DR, Boes M, Busby WH, Booth BA, Dake BL, Sandra A. Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart. Endocrinology 1990 : 127 : 1078 1086.
4. Belcastro AN. Skeletal muscle calcium-activated neutral protease (calpain) with exercise. J Appl Physiol 1993 : 74 : 1381 1386.
5. Berg U, Bang P, Carlsson-Skwirut C. Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3 but not of IGFBP-1. Biol Chem 2007 : 388 : 859 863.
6. Berg U, Gustafsson T, Sundberg CJ, Carlsson-Skwirut C, Hall K, Jakeman P, Bang P. Local changes in the insulin-like growth factor system in human skeletal muscle assessed by microdialysis and arterio-venous differences technique. Growth Horm IGF Res 2006 : 16 : 217 223.
7. Berg U, Saltin B, Hall K. Net fluxes of IGF-I, IGFBP-1, insulin, GH and energy substrates over contracting muscle during prolonged exercise in healthy men. Endocrinol Metab 1997 : 4 : 313 320.
8. Castellani JW, Delany JP, O'Brien C, Hoyt RW, Santee WR, Young AJ. Energy expenditure in men and women during 54 h of exercise and caloric deprivation. Med Sci Sports Exerc 2006 : 38 : 894 900.
9. Colon E, Svechnikov KV, Carlsson-Skwirut C, Bang P, Soder O. Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors. Endocrinology 2005 : 146 : 221 230.
10. Coppock HA, White A, Aplin JD, Westwood M. Matrix metalloprotease-3 and -9 proteolyze insulin-like growth factor-binding protein-1. Biol Reproduct 2004 : 71 : 438 443.
11. Dall R, Lange KH, Kjaer M, Jorgensen JO, Christiansen JS, Orskov H, Flyvbjerg A. No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes. J Clin Endocrinol Metab 2001 : 86 : 669 674.
12. Davidson JR, Moldofsky H, Lue FA. Growth hormone and cortisol secretion in relation to sleep and wakefulness. J Psychiatry Neurosci 1991 : 16 : 96 102.
13. Eliakim A, Brasel JA, Mohan S, Wong WL, Cooper DM. Increased physical activity and the growth hormone-IGF-I axis in adolescent males. Am J Physiol 1998 : 275 : R308 R314.
14. Feasson L, Stockholm D, Freyssenet D, Richard I, Duguez S, Beckmann JS, Denis C. Molecular adaptations of neuromuscular disease-associated proteins in response to eccentric exercise in human skeletal muscle. J Physiol 2002 : 543 : 297 306.
15. Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002 : 23 : 824 854.
16. Fowlkes JL, Enghild JJ, Suzuki K, Nagase H. Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. J Biol Chem 1994 : 269 : 25742 25746.
17. Friedl KE, Moore RJ, Hoyt RW, Marchitelli LJ, Martinez-Lopez LE, Askew EW. Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol 2000 : 88 : 1820 1830.
18. Giudice LC. Insulin-like growth factor family in Graafian follicle development and function. J Soc Gynecol Investig 2001 : 8 : S26 S29.
19. Gomez-Merino D, Chennaoui M, Drogou C, Guezennec CY. Influence of energy deficiency on the insulin-like growth factor I axis in a military training program. Horm Metab Res 2004 : 36 : 506 511.
20. Hackney AC. Endurance exercise training and reproductive endocrine dysfunction in men: alterations in the hypothalamic-pituitary-testicular axis. Curr Pharm Des 2001 : 7 : 261 273.
21. Hossenlopp P, Segovia B, Lassarre C, Roghani M, Bredon M, Binoux M. Evidence of enzymatic degradation of insulin-like growth factor-binding proteins in the 150 K complex during pregnancy. J Clin Endocrinol Metab 1990 : 71 : 797 805.
22. Hoyt RW, Friedl KE. Field studies of exercise and food deprivation. Curr Opin Clin Nutr Metab Care 2006 : 9 : 685 690.
23. Hoyt RW, Opstad PK, Haugen AH, DeLany JP, Cymerman A, Friedl KE. Negative energy balance in male and female rangers: effects of 7 d of sustained exercise and food deprivation. Am J Clin Nutr 2006 : 83 : 1068 1075.
24. Kanaley JA, Frystyk J, Moller N, Dall R, Chen JW, Nielsen SC, Christiansen JS, Jorgensen JO, Flyvbjerg A. The effect of submaximal exercise on immuno- and bioassayable IGF-I activity in patients with GH-deficiency and healthy subjects. Growth Horm IGF Res 2005 : 15 : 283 290.
25. Knechtle B, Zapf J, Zwyssig D, Lippuner K, Hoppeler H. Energiumsatz und muskelstruktur bei Langzeitbelastung: eine Fallstudie. Sportzmed Sporttraumatol 2003 : 51 : 180 187.
26. Lang CH, Vary TC, Frost RA. Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis. Endocrinology 2003 : 144 : 3922 3933.
27. Lewitt MS, Denyer GS, Cooney GJ, Baxter RC. Insulin-like growth factor-binding protein-1 modulates blood glucose levels. Endocrinology 1991 : 129 : 2254 2256.
28. Loucks AB, Mortola JF, Girton L, Yen SS. Alterations in the hypothalamic-pituitary-ovarian and the hypothalamic-pituitary-adrenal axes in athletic women. J Clin Endocrinol Metab 1989 : 68 : 402 411.
29. Loucks AB, Thuma JR. Luteinizing hormone pulsatility is disrupted at a threshold of energy availability in regularly menstruating women. J Clin Endocrinol Metab 2003 : 88 : 297 311.
30. Nemet D, Connolly PH, Pontello-Pescatello AM, Rose-Gottron C, Larson JK, Galassetti P, Cooper DM. Negative energy balance plays a major role in the IGF-I response to exercise training. J Appl Physiol 2004 : 96 : 276 282.
31. Nemet D, Oh Y, Kim HS, Hill M, Cooper DM. Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics 2002 : 110 : 681 689.
32. Nindl BC. Exercise modulation of growth hormone isoforms: current knowledge and future directions for the exercise endocrinologist. Br J Sports Med 2007 : 41 : 346 348.
33. Nindl BC, Alemany JA, Kellogg MD, Rood J, Allison SA, Young AJ, Montain SJ. Utility of circulating Igf-I as a biomarker for assessing body composition changes in men during periods of physical activity, energy and sleep restriction. J Appl Physiol 2007a : 103 : 340 346.
34. Nindl BC, Barnes BR, Alemany JA, Frykman PN, Shippee RL, Friedl KE. Physiological consequences of U.S. army ranger training. Med Sci Sports Exerc 2007b : 39 : 1380 1387.
35. Nindl BC, Rarick KR, Castellani JW, Tuckow AP, Patton JF, Young AJ, Montain SJ. Altered secretion of growth hormone and luteinizing hormone after 84 h of sustained physical exertion superimposed on caloric and sleep restriction. J Appl Physiol 2006 : 100 : 120 128.
36. Nindl BC, Scoville CR, Sheehan KM, Leone CD, Mello RP. Gender differences in regional body composition and somatotrophic influences of IGF-I and leptin. J Appl Physiol 2002 : 92 : 1611 1618.
37. Norrelund H, Frystyk J, Jorgensen JO, Moller N, Christiansen JS, Orskov H, Flyvbjerg A. The effect of growth hormone on the insulin-like growth factor system during fasting. J Clin Endocrinol Metab 2003 : 88 : 3292 3298.
38. Opstad PK. Androgenic hormones during prolonged physical stress, sleep, and energy deficiency. J Clin Endocrinol Metab 1992 : 74 : 1176 1183.
39. Poortmans JR, Vanderstraeten J. Kidney function during exercise in healthy and diseased humans. An update. Sports Med 1994 : 18 : 419 437.
40. Rabkin R, Schaefer F. New concepts: growth hormone, insulin-like growth factor-I and the kidney. Growth Horm IGF Res 2004 : 14 : 270 276.
41. Redman LM, Loucks AB. Menstrual disorders in athletes. Sports Med 2005 : 35 : 747 755.
42. Renehan AG, Frystyk J, Howell A, O'Dwyer ST, Shalet SM, Flyvbjerg A. The effects of sex steroid replacement therapy on an expanded panel of IGF-related peptides. Growth Horm IGF Res 2007 : 17 : 210 219.
43. Rosendal L, Langberg H, Flyvbjerg A, Frystyk J, Orskov H, Kjaer M. Physical capacity influences the response of insulin-like growth factor and its binding proteins to training. J Appl Physiol 2002 : 93 : 1669 1675.
44. Rullman E, Rundqvist H, Wagsater D, Fischer H, Eriksson P, Sundberg CJ, Jansson E, Gustafsson T. A single bout of exercise activates matrix metalloproteinase in human skeletal muscle. J Appl Physiol 2007 : 102 : 2346 2351.
45. Schwarz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab 1996 : 81 : 3492 3497.
46. Sjogren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Tornell J, Isaksson OG, Jansson JO, Ohlsson C. Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci USA 1999 : 96 : 7088 7092.
47. Spencer MJ, Lu B, Tidball JG. Calpain II expression is increased by changes in mechanical loading of muscle in vivo. J Cell Biochem 1997 : 64 : 55 66.
48. Stokes K. Growth hormone responses to sub-maximal and sprint exercise. Growth Horm IGF Res 2003 : 13 : 225 238.
49. Suikkari AM, Sane T, Seppala M, Yki-Jarvinen H, Karonen SL, Koivisto VA. Prolonged exercise increases serum insulin-like growth factor-binding protein concentrations. J Clin Endocrinol Metab 1989 : 68 : 141 144.
50. Veldhuis JD, Anderson SM, Iranmanesh A, Bowers CY. Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations. J Clin Endocrinol Metab 2005 : 90 : 1613 1617.
51. Veldhuis JD, Evans WS, Demers LM, Thorner MO, Wakat D, Rogol AD. Altered neuroendocrine regulation of gonadotropin secretion in women distance runners. J Clin Endocrinol Metab 1985 : 61 : 557 563.
52. Weir JB. New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949 : 109 : 1 9.
53. White JA, Ward C, Nelson H. Ergogenic demands of a 24 hour cycling event. Br J Sports Med 1984 : 18 : 165 171.
54. Whyte GP, George K, Sharma S, Lumley S, Gates P, Prasad K, McKenna WJ. Cardiac fatigue following prolonged endurance exercise of differing distances. Med Sci Sports Exerc 2000 : 32 : 1067 1072.
55. Yakar S, Liu JL, Fernandez AM, Wu Y, Schally AV, Frystyk J, Chernausek SD, Mejia W, Le Roith D. Liver-specific iGF-1 gene deletion leads to muscle insulin insensitivity. Diabetes 2001 : 50 : 1110 1118.