Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen

European Journal of Clinical Investigation

Volumn 35, Issue 3, 2005, Pages 220-225

  Sakamoto, M ^a,b   Ueno, T ^a,b,c   Nakamura, T ^a,b   Sakata, R ^a,b   Hasimoto, O ^a,b   Torimura, T ^a,b   Sata, M ^a,b  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KURUME UNIVERSITY   (Japan)

^c NONE   (Japan)

Author keywords

17 estradiol; Nitric oxide; Oestrogen receptor; Portal hypertension; Sinusoidal endothelial cell

Indexed keywords

4,5 DIAMINOFLUORESCEIN DIACETATE; ANTIESTROGEN; CITRULLINE; DIMETHYLNITROSAMINE; ESTRADIOL VALERATE; FULVESTRANT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL LEVEL; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENERAL CONDITION IMPROVEMENT; IMAGE ANALYSIS; INCUBATION TIME; INJECTION; LIVER BLOOD FLOW; LIVER CELL CULTURE; LIVER CIRRHOSIS; LIVER SINUSOID; MALE; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT;

EID: 14844320846     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2005.01476.x     Document Type: Article

References (37)

1. Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J Clin Invest 1997;100:2923-30.
2. Billiar TR, Curran RD, Stuehr DJ, West MA, Bentz BG, Simmons RL. An 1-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro. J Exp Med 1989;169:1467-72.
3. Rockey DC, Chung JJ. Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility. J Clin Invest 1995;95:1199-206.
4. Sakamoto M, Ueno T, Sugawara H, Torimura T, Tsuji R, Sujaku K et al. Relaxing effect of interleukin-1 on rat cultured Ito cells. Hepatology 1997;25:1412-7.
5. Curran RD, Billiar TR, Stuehr DJ, Hofmann K, Simmons RL. Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells. J Exp Med 1989;170:1769-74.
6. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature 1988;333:664-6.
7. Beasley D, Schwartz JH, Brenner BM. Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells. J Clin Invest 1991;87:602-8.
8. Sakamoto M, Ueno T, Kin M, Ohira H, Torimura T, Inuzuka S et al. Ito cell contraction in response to endothelin-1 and substance P. Hepatology 1993;18:978-83.
9. Gondo K, Ueno T, Sakamoto M, Sakisaka S, Sata M, Tanikawa K. The endothelin-1 binding site in rat liver tissue: light- and electron-microscopic autoradiographic studies. Gastroenterology 1993;104:1745-9.
10. Pinzani M, Failli P, Ruocco C, Casini A, Milani S, Baldi E et al. Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest 1992;90:642-6.
11. Rockey D. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997;25:2-5.
12. Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998;114:344-51.
13. Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999;117:1222-8.
14. Maruyama Y, Adachi Y, Aoki N, Suzuki Y, Shinohara H, Yamamoto T. Mechanism of feminization in male patients with non-alcoholic liver cirrhosis: role of sex hormone-binding globulin. Gastroenterol Jpn 1991;26:435-9.
15. Yasuda M, Shimizu I, Shiba M, Ito S. Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. Hepatology 1999;29:719-27.
16. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett 1995;360:291-3.
17. Hayashi T, Yamada K, Esaki T, Kuzuya M, Satake S, Ishikawa T et al. Estrogen increases endothelial nitric oxide by a receptor-mediated system. Biochem Biophys Res Commun 1995;214:847-55.
18. Sakamoto M, Ueno T, Nakamura T, Hashimoto O, Sakata R, Kin M et al. Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells. J Hepatol 2001;34:858-64.
19. Nakamura T, Sakata S, Ueno T, Sata M, Ueno H. Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 2000;32:247-55.
20. Shakado S, Sakisaka S, Noguchi K, Yoshitake M, Harada M, Mimura Y et al. Effects of extracellular matrices on tube formation of cultured rat hepatic sinusoidal endothelial cells. Hepatology 1995;22:969-73.
21. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42.
22. Farhat MY, Lavigne MC, Ramwell PW. The vascular protective effects of estrogen. FASEB J 1996;10:615-24.
23. Kawano H, Motoyama T, Kugiyama K, Hirashima O, Ohgushi M, Fujii H et al. Gender difference in improvement of endothelium-dependent vasodilation after estrogen supplementation. J Am Coll Cardiol 1997;30:914-9.
24. Roqué M, Heras M, Roig E, Masotti M, Rigol M, Betriu A et al. Short-term effects of transdermal estrogen replacement therapy on coronary vascular reactivity in postmenopausal women with angina pectoris and normal results on coronary angiograms. J Am Coll Cardiol 1998;31:139-43.
25. Best PJM, Berger PB, Miller VM, Lerman A. The effect of estrogen replacement therapy on plasma nitric oxide and endothelin-1 levels in postmenopausal women. Ann Intern Med 1998;128:285-8.
26. Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME, Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. J Clin Invest 1999;103:401-6.
27. Sudhir K, Chou TM, Chatterjee K, Smith EP, Williams TC, Kane JP et al. Premature coronary artery disease associated with a disruptive mutation in the estrogen receptor gene in a man. Circulation 1997;96:3774-7.
28. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801-11.
29. 2+ uptake. Circ Res 1997;81:242-8.
30. Zaman SN, Melia WM, Johnson RD, Portmann BC, Johnson PJ, Williams R. Risk factors in development of hepatocellular carcinoma in cirrhosis, prospective study of 613 patients. Lancet 1985;2:1357-59.
31. Villa E, Baldini GM, Pasquinelli C, Melegari M, Cariani E, Di Chirico G et al. Risk factors for hepatocellular carcinoma in Italy. Male sex, hepatitis B virus, non-A non-B infection, and alcohol. Cancer 1988;62:611-5.
32. Zhou Y, Shimizu I, Lu G, Itonaga M, Okamura Y, Shono M et al. Hepatic stellate cells contain the functional estrogen receptor beta but not the estrogen receptor alpha in male and female rats. Biochem Biophys Res Commun 2001;286:1059-65.
33. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J et al. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol 1998;274:G669-76.
34. Shupnik MA, Gordon MS, Chin WW. Tissue-specific regulation of rat estrogen receptor mRNAs. Mol Endocrinol 1989;3:660-5.
35. Nakatsubo N, Kojima H, Kikuchi K, Nagoshi H, Hirata Y, Maeda D et al. Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins. FEBS Lett 1998;427:263-6.
36. Goetz RM, Thatte HS, Prabhakar P, Cho MR, Michel T, Golan DE. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 1999;96:2788-93.
37. Harada H, Pavlick KP, Hines IN, Lefer DJ, Hoffman JM, Bharwani S et al. Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: role of endothelial cell nitric oxide synthase. Proc Natl Acad Sci USA 2003;100:739-44.