Molecular dynamics simulations for drug dosage form development: Thermal and solubility characteristics for hot-melt extrusion

Molecular Simulation

Volumn 34, Issue 10-15, 2008, Pages 1197-1207

  Maus, Martin ^a   Wagner, Karl G ^a,b   Kornherr, Andreas ^c   Zifferer, Gerhard ^d  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Mondi Uncoated Fine Paper ^*  (Austria)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Drug dosage form; Glass transition; Plasticiser; Polymer; Solubility

Indexed keywords

ABS RESINS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DOSAGE; DRUG INTERACTIONS; DRUG PRODUCTS PLANTS; DYNAMICS; EXTRUSION; FORMING; FUNCTIONAL POLYMERS; GLASS; GLASS TRANSITION; LASER INTERFEROMETRY; MELT SPINNING; MIXTURES; MOLECULAR DYNAMICS; PLASTICIZERS; POLYMERS; PRODUCT DEVELOPMENT; PROJECT MANAGEMENT; QUANTUM CHEMISTRY; SILICON SOLAR CELLS; SOLUBILITY; STUDIOS; TERNARY SYSTEMS;

ACETYL TRIBUTYL CITRATES; ACTIVE INGREDIENTS; ACTIVE PHARMACEUTICAL INGREDIENTS; AMORPHOUS CELLS; CATIONIC POLYMETHACRYLATE; COHESIVE ENERGY DENSITIES; COMPASS FORCE FIELDS; DIBUTYL SEBACATE; DRUG RELEASES; EXPERIMENTAL DATUMS; FORCE FIELDS; GLASS TRANSITION TEMPERATURES; IBUPROFENS; MELT EXTRUSIONS; MOLECULAR DYNAMICS SIMULATIONS; PHARMACEUTICAL DRUGS; PLASTICISER; PLASTICISERS; POLYMER DRUGS; POLYMER MIXTURES; QUALITATIVE APPROACHES; QUANTITATIVE PREDICTIONS; SIMULATED DATUMS; SOLID STATES; SOLUBILITY CHARACTERISTICS; SPECIFIC VOLUMES;

DRUG PRODUCTS;

EID: 56749183437     PISSN: 08927022     EISSN: 10290435     Source Type: Journal    
DOI: 10.1080/08927020802411695     Document Type: Article

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