Endotoxin contamination contributes to the pulmonary inflammatory and functional response to Aspergillus fumigatus extract inhalation in heaves horses

Clinical and Experimental Allergy

Volumn 33, Issue 9, 2003, Pages 1289-1296

  Pirie, R S ^a   Dixon, P M ^a   McGorum, B C ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Aspergillus fumigatus; Endotoxin; Heaves; Mould extract; Organic dust

Indexed keywords

ENDOTOXIN; LIPOPOLYSACCHARIDE; PLACEBO; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; FEMALE; HEAVES; HORSE; HORSE DISEASE; INFLAMMATION; LUNG; LUNG LAVAGE; MALE; MOULD; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ANIMAL FEED; ANIMALS; ASPERGILLUS FUMIGATUS; BRONCHOALVEOLAR LAVAGE FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DUST; ENDOTOXINS; FEMALE; HORSE DISEASES; HORSES; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG DISEASES; MALE; NEUTROPHILS; PLANT EXTRACTS;

EID: 0043237869     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2745.2003.01679.x     Document Type: Article

References (40)

1. Michel O, Nagy AM, Schroeven M et al. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 1997; 156:1157-64.
2. Derksen FJ. Chronic obstructive pulmonary-disease (heaves) as an inflammatory condition. Equine Vet J 1993; 25:257-8.
3. Derksen FJ, Robinson NE, Scott JS, Stick JA. Aerosolised Micropolyspora faeni antigen as a cause of pulmonary dysfunction in ponies with recurrent airway obstruction (heaves). Am J Vet Res 1988; 49:933-8.
4. McGorum BC, Dixon PM, Halliwell RE. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet J 1993; 25:261-7.
5. McPherson EA, Lawson GHK, Murphy JR, Nicholson JM, Breeze RG, Pirie H. Chronic obstructive pulmonary disease (COPD) in horses: Aetiological studies: response to intradermal and inhalation antigenic challenge. Equine Vet J 1979; 11:159-66.
6. Dutkiewicz J, Pomorski ZJH, Sitkowska J et al. Airborne microorganisms and endotoxin in animal houses. Grana 1994; 33:85-90.
7. Olenchock SA, Murphy SA, Mull JC, Lewis DM. Endotoxin and complement activation in an analysis of environmental dusts from a horse barn. Scand J Work Environ Health 1992; 18 (Suppl. 2):58-9.
8. Tanner MK, Swinker AM, Beard ML et al. Effect of phone book paper versus sawdust and straw bedding on the presence of airborne Gram-negative bacteria, fungi and endotoxin in horse stalls. J Equine Vet Sci 1998; 18:457-61.
9. McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet J 1998; 30:430-4.
10. Pirie RS, Dixon PM, Collie DDS, McGorum BC. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Vet J 2001; 33:311-8.
11. Hunt LW, Gleich GJ, Ohnishi T et al. Endotoxin contamination causes neutrophilia following pulmonary allergen challenge. Am J Respir Crit Care Med 1994; 149:1471-5.
12. Hunt LW, Mansfield ES, Sur S, Gleich GJ. Late neutrophilic response to bronchial allergen challenge: a response to endotoxin. J Allergy Clin Immunol 1992; 89:334.
13. Sur S, Crotty TB, Kephart GM et al. Sudden-onset fatal asthma: a distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa. Am Rev Respir Dis 1993; 148:713-9.
14. Edwards JH. The double dialysis of method of producing farmer's lung antigens. J Lab Clin Med 1972; 79:683-8.
15. Thorn J. Organic dusts and airways inflammation with reference to the specific agents endotoxin and (1-3)-β-D-glucan. PhD Thesis, University of Gothenburg, Gothenburg, 1999.
16. Brazil TJ. Pulmonary neutrophil recruitment, activation and clearance in equine COPD. PhD Thesis, University of Edinburgh, Edinburgh, 2000.
17. Pirie RS, Collie DDS, Dixon PM, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. II: Effects of inhaled HDS on control and heaves horses. Equine Vet J 2002; 34:337-43.
18. Campbell MJ, Gardner MJ. Calculating confidence intervals for some non-parametric analyses. In: Statistics with confidence: confidence intervals, statistical guidelines. London: BMJ, 1994:71-8.
19. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986; 1:307-10.
20. British Standards Institution. Precision of Test Methods. I: Guide for the Determination and Reproducibility for a Standard Test Method, BS 5497, Part 1. BSI, London, 1979.
21. Broadstone RV, Gray PR, Robinson NE, Derksen FJ. Effects of xylazine on airway function in ponies with recurrent airway obstruction. Am J Vet Res 1992; 53:1813-7.
22. Darsow U, Vieluf D, Berg B et al. Dose-response study of atopy patch test in children with atopic eczema. Pediatr Asthma Allergy Immunol 1999; 13:115-22.
23. Hsiue TR, Lei HY, Hsieh AL, Wang TY, Chang HY, Chen CR. Mite-induced allergic airway inflammation in guinea pigs. Int Arch Allergy Immunol 1997; 112:295-302.
24. McGorum BC, Dixon PM, Halliwell REW. Quantification of histamine in plasma and pulmonary fluids from horses with chronic obstructive pulmonary disease, before and after natural (hay and straw) challenges. Vet Immunol Immunopathol 1993; 36:223-37.
25. Cairns JA, Walls AF. Mast cell tryptase is a mitogen for epithelial cells: stimulation of IL-8 production and intercellular adhesion molecule-1 expression. J Immunol 1996; 156:275-83.
26. Clarke AF. Air hygiene and equine respiratory disease. In Prac 1987; 9:196-204.
27. Clarke AF, Madelin T. Technique for assessing respiratory health hazards from hay and other source materials. Equine Vet J 1987; 19:442-7.
28. Pirie RS, McLachlan G, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 1: Preparation and composition of HDS. Equine Vet J 2002; 34:332-7.
29. Gerada JE, Leung DYM, Thatayatikom A, Schiltz AM, Lui AH. Endotoxin is a major IL-12 inducing component of house dust. J Allergy Clin Immunol 2001; 107:S92.
30. Jagielo PJ, Thorne PS, Kern JA, Quinn TJ, Schwartz DA. Role of endotoxin in grain dust-induced lung inflammation in mice. Am J Physiol Lung Cell Mol Physiol 1996; 14:L1052-59.
31. Michel O, Ginanni R, Duchateau J, Vertongen F, Lebon B, Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 1991; 21:441-8.
32. Michel O. Endotoxin and asthma. Rev Fr Allergol 1996; 36:942-5.
33. Michel O, Kips J, Duchateau J et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154:1641-6.
34. Rizzo MC, Naspitz CK, FernandezCaldas E, Lockey RF, Mimica I, Sole D. Endotoxin exposure and symptoms in asthmatic children. Pediatr Allergy Immunol 1997; 8:121-6.
35. Goldsmith CAW, Hamada K, Ning YY et al. Effects of environmental aerosols on airway hyper-responsiveness in a murine model of asthma. Inhalation Toxicol 1999; 11:981-98.
36. Rylander R, Holt PG. (1->3)-β-D-glucan and endotoxin modulate immune response to inhaled allergen. Med Inflammation 1998; 7:105-10.
37. Slater JE, Paupore E, Truscott W. Lipopolysaccharide (LPS) augments IgG and IgE responses of mice to the latex allergen hev b 5. J Allergy Clin Immunol 1998; 101:851.
38. Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22:604-12.
39. Martin TR, Mathison JC, Tobias PS et al. Lipopolysaccharide binding-protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide: implications for cytokine production in normal and injured lungs. J Clin Invest 1992; 90:2209-19.
40. Dubin W, Martin TR, Swoveland P et al. Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD 14 in bronchoalveolar compartment. Am J Physiol Lung Cell Mol Physiol 1996; 14:L736-44.