Movement of the iron-sulfur head domain of cytochrome bc1 transiently opens the catalytic Qo site for reaction with oxygen

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12365-12370

  Borek, Arkadiusz ^a   Sarewicz, Marcin ^a   Osyczka, Artur ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTRON GUNS; ELECTRONS; ENERGY CONVERSION; ENZYMES; HEMOGLOBIN; LEAKAGE (FLUID); NETWORKS (CIRCUITS); PORPHYRINS; PROBABILITY; SULFUR;

BIOLOGICAL ENERGIES; CATALYTIC CYCLES; COFACTOR; COFACTORS; CYTOCHROME C; DO-MAINS; ELECTRON FLOWS; ELECTRON REDUCTIONS; JOINT ACTIONS; KEY ENZYMES; MOTIVE FORCES; REDUCED STATES; SEMIQUINONE; SIDE REACTIONS; SINGLE ELECTRONS; SUPEROXIDE; SUPEROXIDE GENERATIONS; SUPEROXIDE PRODUCTIONS; TWO CHAINS;

OXYGEN;

CYTOCHROME C1; HEME; IRON; OXYGEN; SULFUR; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; CATALYSIS; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME ISOLATION; ENZYME MECHANISM; ENZYME MODIFICATION; PRIORITY JOURNAL; PROTEIN DOMAIN; REDUCTION;

BINDING, COMPETITIVE; BIOCATALYSIS; CATALYTIC DOMAIN; COENZYMES; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; IRON; MODELS, MOLECULAR; MOVEMENT; OXYGEN; PROTEIN BINDING; RHODOBACTER CAPSULATUS; SULFUR; SUPEROXIDES; TIME FACTORS;

EID: 56749172576     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801207f     Document Type: Article

References (34)

1. Nicholls, D. G., and Ferguson, S. J. (2002) Bioenergetics, Vol. 3, Academic Press, New York.
2. 1 complex in the respiratory chain: Protonmotive ubiquinone cycle. FEBS Lett. 56, 1-6.
3. Brandt, U., and Trumpower, B. L. (1994) The protonmotive Q cycle in mitochondria and bacteria. Crit. Rev. Biochem. Mol. Biol. 29, 165-197.
4. 1: A new device for electron transfer in proteins. Trends Biochem. Sci. 26, 445-451.
5. 1 complex. Biochemistry 41, 7866-7874.
6. Osyczka, A., Moser, C. C., Daldal, F., and Dutton, P. L. (2004) Reversible redox energy coupling in electron transfer chains. Nature 427, 607-612.
7. Osyczka, A., Moser, C. C., and Dutton, P. L. (2005) Fixing the Q cycle. Trends Biochem. Sci. 30, 176-182.
8. Rich, P. R. (2004) The quinone chemistry of bc complexes. Biochim. Biophys. Acta 1658, 165-171.
9. 1 complex: A new gating mechanism that prevents short circuits. Biochim. Biophys. Acta 1757, 1019-1034.
10. Boveris, A., and Cadenas, E. (1975) Mitochondrial production of superoxide anions and its relationship to the antymycin insensitive respiration. FEBS Lett. 54, 311-314.
11. 1 site of the mitochondrial respiratory chain. FEBS Lett. 155, 19-24.
12. Zhang, L., Yu, L., and Yu, C. A. (1998) Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria. J. Biol. Chem. 273, 33972-33976.
13. St-Pierre, J., Buckingham, J. A., Roebuck, S. J., and Brand, M. D. (2002) Topology of superoxide production from different sites in the mitochondrial electron transport chain. J. Biol. Chem. 277, 44784-44790.
14. Muller, F. L., Liu, Y., and Van Remmen, H. (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279, 49064-49073.
15. Chen, Q., Vazquez, E. J., Moghaddas, S., Hoppel, C. L., and Lesnefsky, E. J. (2003) Production of reactive oxygen species by mitochondria. Central role of complex III. J. Biol. Chem. 278, 36027-36031.
16. Guzy, R. D., and Schumacker, P. T. (2006) Oxygen sensing by mitochondria at complex III: The paradox of increased reactive oxygen species during hypoxia. Exp. Physiol. 91, 807-819.
17. 1 complex. J. Biol. Chem. 275, 13535-13541.
18. 1 complex probed by superoxide production. Biochemistry 42, 6493-6499.
19. 1 complex. J. Biol. Chem. 281, 38459-38465.
20. 1 complex. Arch. Biochem. Biophys. 419, 198-206.
21. Cape, J. L., Bowman, M. K., and Kramer, D. M. (2006) Understanding the cytochrome bc complexes by what they don't do. The Q cycle at 30. Trends Plant Sci. 11, 46-55.
22. 1 complex: Importance for the Q-cycle and superoxide production. Proc. Natl. Acad. Sci. U.S.A. 104, 7887-7892.
23. 1 complex. Mechanistic and physiological implications. J. Biol. Chem. 280, 34654-34660.
24. 1 complex. J. Biol. Chem. 283, 21649-21654.
25. 1 complex and for photosynthetic growth of Rhodobacter capsulatus. Proc. Natl. Acad. Sci. U.S.A. 88, 492-496.
26. 1 complex of Rhodobacter capsulatus. Biochemistry 31, 11864-11873.
27. 1 and its implications for energy conversion. Proc. Natl. Acad. Sci. U.S.A. 97, 4567-4572.
28. o) site with purified Fe-S protein subunit. Biochemistry 37, 16242-16251.
29. 2 oxidoreductase complex of Rhodopseudomonas sphaeroides. FEBS Lett. 178, 336-342.
30. 2 oxidoreductase. Biochim. Biophys. Acta 935, 273-291.
31. Zhang, H., Osyczka, A., Dutton, P. L., and Moser, C. C. (2007) Exposing the complex III Qo semiquinone radical. Biochim. Biophys. Acta 1767, 883-887.
32. 1 complex. FEBS Lett. 178, 343-350.
33. Page, C. C., Moser, C. C., Chen, X., and Dutton, P. L. (1999) Natural engineering principles of electron tunneling in biological oxidation-reduction. Nature 402, 47-52.
34. - radicals in aqueous solution. J. Phys. Chem. Ref. Data 14, 1041-1100.