Maternal administration of betamethasone inhibits proliferation induced by fetal tracheal occlusion in the nitrofen rat model for congenital diaphragmatic hernia: A placebo-controlled study

Pediatric Surgery International

Volumn 24, Issue 12, 2008, Pages 1287-1295

  Mayer, Steffi ^a,c   Klaritsch, Philipp ^a   Sbragia, Lourenço ^a   Toelen, Jaan ^b   Till, Holger ^c   Deprest, Jan A ^a,d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Congenital diaphragmatic hernia; Glucocorticoids; Nitrofen; Proliferation; Tracheal occlusion

Indexed keywords

BETAMETHASONE; CYCLINE; KI 67 ANTIGEN; NITROFEN; OLIVE OIL; PLACEBO; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AUTOPSY; BODY WEIGHT; CONFERENCE PAPER; CONGENITAL DIAPHRAGM HERNIA; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FETUS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUNG WEIGHT; MATERNAL TREATMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRACHEA OBSTRUCTION;

ANIMALS; BETAMETHASONE; DISEASE MODELS, ANIMAL; FEMALE; FETAL ORGAN MATURITY; FETAL WEIGHT; GLUCOCORTICOIDS; HERNIA, DIAPHRAGMATIC; LIGATION; LUNG; LUNG DISEASES; ORGAN SIZE; PHENYL ETHERS; PREGNANCY; RATS; RATS, WISTAR; SURGICAL INSTRUMENTS; TERATOGENS; TRACHEA;

EID: 56649118858     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-008-2269-7     Document Type: Conference Paper

References (49)

1. D Gallot K Coste C Francannet H Laurichesse C Boda S Ughetto P Vanlieferinghen T Scheye F Vendittelli A Labbe PJ Dechelotte V Sapin D Lemery 2006 Antenatal detection and impact on outcome of congenital diaphragmatic hernia: a 12-year experience in Auvergne, France Eur J Obstet Gynecol Reprod Biol 125 2 202 205
2. G Stege A Fenton B Jaffray 2003 Nihilism in the 1990s: the true mortality of congenital diaphragmatic hernia Pediatrics 112 3 Pt 1 532 535
3. TB Kinane 2007 Lung development and implications for hypoplasia found in congenital diaphragmatic hernia Am J Med Genet C Semin Med Genet 145 2 117 124
4. J Jani KH Nicolaides RL Keller A Benachi CF Peralta R Favre O Moreno D Tibboel S Lipitz A Eggink P Vaast K Allegaert M Harrison J Deprest 2007 Antenatal-CDH-Registry Group. Observed to expected lung area to head circumference ratio in the prediction of survival in fetuses with isolated diaphragmatic hernia Ultrasound Obstet Gynecol 30 1 67 71
5. M Cannie J Jani J Meersschaert K Allegaert E Done' G Marchal J Deprest S Dymarkowski 2008 Prenatal prediction of survival in isolated diaphragmatic hernia using observed to expected total fetal lung volume determined by magnetic resonance imaging based on either gestational age or fetal body volume Ultrasound Obstet Gynecol 32 5 633 639
6. E Doné L Gucciardo T Van Mieghem J Jani M Cannie D Van Schoubroeck R Devlieger LD Catte P Klaritsch S Mayer V Beck A Debeer E Gratacos K Nicolaides J Deprest 2008 Prenatal diagnosis, prediction of outcome and in utero therapy of isolated congenital diaphragmatic hernia Prenat Diagn 28 7 581 591
7. Y Kitano M Kanai P Davies D von Allmen EY Yang A Radu Y Kitano NS Adzick AW Flake 2001 BAPS prize-1999: lung growth induced by prenatal tracheal occlusion and its modifying factors: a study in the rat model of congenital diaphragmatic hernia J Pediatr Surg 36 2 251 259
8. CJ Chapin R Ertsey J Yoshizawa A Hara LS Sbragia JJ Greer JA Kitterman 2005 Congenital diaphragmatic hernia, tracheal occlusion, thyroid transcription factor-1, and fetal pulmonary epithelial maturation Am J Physiol Lung Cell Mol Physiol 289 1 L44 L52
9. M Kanai Y Kitano DV Allmen P Davies NS Adzick AW Flake 2001 Fetal tracheal occlusion in the rat model of nitrofen-induced congenital diaphragmatic hernia: tracheal occlusion reverses the arterial structural abnormality J Pediatr Surg 36 6 839 845
10. J Yoshizawa CJ Chapin LS Sbragia R Ertsey JA Gutierrez CT Albanese JA Kitterman 2003 Tracheal occlusion stimulates cell cycle progression and type I cell differentiation in lungs of fetal rats Am J Physiol Lung Cell Mol Physiol 285 2 L344 L353
11. MG Davey E Danzer U Schwarz L Robinson S Shegu NS Adzick AW Flake HL Hedrick 2006 Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion Pediatr Pulmonol 41 12 1188 1196
12. MG Davey S Shegu E Danzer E Ruchelli NS Adzick AW Flake HL Hedrick 2007 Pulmonary arteriole muscularization in lambs with diaphragmatic hernia after combined tracheal occlusion/glucocorticoid therapy Am J Obstet Gynecol 197 4 381.e1-7
13. J Deprest E Gratacos KH Nicolaides 2004 Fetoscopic tracheal occlusion (FETO) for severe congenital diaphragmatic hernia: evolution of a technique and preliminary results Ultrasound Obstet Gynecol 24 2 121 126
14. JC Jani KH Nicolaides E Gratacos H Vandecruys JA Deprest FETO Task Group 2006 Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO) Am J Obstet Gynecol 195 6 1646 1650
15. Jani J, Benachi A, Nicolaides K, Allegaert K, Gratacós E, Mazkereth R, Matis J, Tibboel D, Van Heijst A, Storme L, Rousseau V, Greenough A, Deprest J; the Antenatal-CDH-Registry group (2008) Prenatal prediction of neonatal morbidity in survivors with congenital diaphragmatic hernia: a multicenter study. Ultrasound Obstet Gynecol. doi: 10.1002/uog.6141
16. L Gucciardo JA Deprest E Done' T Van Mieghem M Van de Velde E Gratacos JC Jani CF Peralta KH Nicolaides 2008 Prediction of outcome in isolated congenital diaphragmatic hernia and its consequences for fetal therapy Best Pract Res Clin Obstet Gynaecol 22 1 123 138
17. NIH consensus (1995) Effect of corticosteroids for fetal maturation on perinatal outcomes. NIH consensus development panel on the effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 273:413-418
18. N Guarino T Oue H Shima P Puri 2000 Antenatal dexamethasone enhances surfactant protein synthesis in the hypoplastic lung of nitrofen-induced diaphragmatic hernia in rats J Pediatr Surg 35 10 1468 1473
19. XI Roubliova AM Van der Biest P Vaast H Lu JC Jani PJ Lewi EK Verbeken D Tibboel JA Deprest 2008 Effect of maternal administration of betamethasone on peripheral arterial development in fetal rabbit lungs Neonatolgy 93 1 64 72
20. XI Roubliova PJ Lewi P Vaast JC Jani EK Verbeken D Tibboel JA Deprest 2008 Effects of betamethasone on peripheral arterial development in term fetal rabbit Pediatr Pulmonol 43 8 795 805
21. P Kapur BA Holm MS Irish J Sokolowski A Patel PL Glick 1999 Lung physiological and metabolic changes in lambs with congenital diaphragmatic hernia after administration of prenatal maternal corticosteroids J Pediatr Surg 34 2 354 356
22. MG Davey E Danzer U Schwarz NS Adzick AW Flake HL Hedrick 2006 Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion Pediatr Res 60 2 131 135
23. KL King JA Cidlowski 1998 Cell cycle regulation and apoptosis Annu Rev Physiol 60 601 617
24. D Kluth R Tenbrinck M von Ekesparre R Kangah P Reich A Brandsma D Tibboel W Lambrecht 1993 The natural history of congenital diaphragmatic hernia and pulmonary hypoplasia in the embryo J Pediatr Surg 28 3 456 462 discussion 462-463
25. TE Langwieler HC Fiegel M Alaamian O Mann I Beshir JR Izbicki D Kluth 2004 The relationship of diaphragmatic defect, liver growth, and lung hypoplasia in nitrofen-induced congenital diaphragmatic hernia in the rat Pediatr Surg Int 20 7 509 514
26. M Bruschettini DL van den Hove D Gazzolo HW Steinbusch CE Blanco 2006 Lowering the dose of antenatal steroids: the effects of a single course of betamethasone on somatic growth and brain cell proliferation in the rat Am J Obstet Gynecol 194 1341 1346
27. AK Lohninger P Böck H Salzer P Sevelda AF Lohninger 1994 Antenatal betamethasone-dose-effects on fetal rat lung morphology and surfactant J Perinat Med 22 4 319 328
28. Y Taira T Oue H Shima E Miyazaki P Puri 1999 Increased tropoelastin and procollagen expression in the lung of nitrofen-induced diaphragmatic hernia in rats J Pediatr Surg 34 5 715 719
29. Rasband WS (1997-2008) ImageJ, US National Institutes of Health, Bethesda, Maryland, USA
30. R Keijzer J Liu J Deimling D Tibboel M Post 2000 Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia Am J Pathol 156 4 1299 1306
31. L Muskhelishvili JR Latendresse RL Kodell EB Henderson 2003 Evaluation of cell proliferation in rat tissues with BrdU, PCNA, Ki-67(MIB-5) immunohistochemistry and in situ hybridization for histone mRNA J Histochem Cytochem 51 12 1681 1688
32. T Scholzen J Gerdes 2000 The Ki-67 protein: from the known and the unknown J Cell Physiol 182 3 311 322
33. P Birner M Ritzi C Musahl R Knippers J Gerdes T Voigtländer H Budka JA Hainfellner 2001 Immunohistochemical detection of cell growth fraction in formalin-fixed and paraffin-embedded murine tissue Am J Pathol 158 6 1991 1996
34. EC Jesudason MG Connell DG Fernig DA Lloyd PD Losty 2000 Cell proliferation and apoptosis in experimental lung hypoplasia J Pediatr Surg 35 1 129 133
35. QS Tong LD Zheng ST Tang GS Jiang QL Ruan FQ Zeng JH Dong 2007 Nitrofen suppresses cell proliferation and promotes mitochondria mediated apoptosis in type II pneumocytes Acta Pharmacol Sin 28 5 672 684
36. DE Kling JJ Schnitzer 2007 Vitamin A deficiency (VAD), teratogenic, and surgical models of congenital diaphragmatic hernia (CDH) Am J Med Genet C Semin Med Genet 145 2 139 157
37. MR Chinoy X Chi RE Cilley 2001 Down-regulation of regulatory proteins for differentiation and proliferation in murine fetal hypoplastic lungs: altered mesenchymal-epithelial interactions Pediatr Pulmonol 32 2 129 141
38. O Boucherat A Benachi B Chailley-Heu ML Franco-Montoya C Elie J Martinovic JR Bourbon 2007 Surfactant maturation is not delayed in human fetuses with diaphragmatic hernia PLoS Med 4 7 e237
39. RJ Bolt MM van Weissenbruch HN Lafeber HA Delemarre-van de Waal 2001 Glucocorticoids and lung development in the fetus and preterm infant Pediatr Pulmonol 32 1 76 91
40. AD Bird KH Tan PF Olsson M Zieba SJ Flecknoe DR Liddicoat R Mollard SB Hooper TJ Cole 2007 Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development J Physiol 585 1 187 201
41. EB Olson 1979 Role of glucocorticoids in lung maturation J Anim Sci 49 1 225 238
42. PL Ballard RA Ballard 1995 Scientific basis and therapeutic regimens for use of antenatal glucocorticoids Am J Obstet Gynecol 173 1 254 262
43. PD Losty BA Pacheco TF Manganaro PK Donahoe RC Jones JJ Schnitzer 1996 Prenatal hormonal therapy improves pulmonary morphology in rats with congenital diaphragmatic hernia J Surg Res 65 1 42 52
44. WD Ford CP Kirby CS Wilkinson ME Furness AJ Slater 2002 Antenatal betamethasone and favourable outcomes in fetuses with 'poor prognosis' diaphragmatic hernia Pediatr Surg Int 18 4 244 246
45. KP Lally P Bagolan S Hosie PA Lally M Stewart CM Cotton KP van Meurs G Alexander 2006 Corticosteroids for fetuses with congenital diaphragmatic hernia: can we show benefit? J Pediatr Surg 41 4 668 674 discussion 668-674
46. PA Khan M Cloutier B Piedoboeuf 2007 Tracheal occlusion: a review of obstructing fetal lungs to make them grow and mature Am J Med Genet C Semin Med Genet 145 2 125 138
47. T Seaborn PA Khan M Cloutier F Maltais B Piedoboeuf 2007 Short-term response to tracheal occlusion during perinatal lung development in mice Exp Lung Res 33 8 441 457
48. RE Boland L Nardo SB Hooper 1997 Cortisol pretreatment enhances the lung growth response to tracheal obstruction in fetal sheep Am J Physiol 273 6 Pt 1 L1126 L1131
49. AW Flemmer JC Jani F Bergmann OJ Muensterer D Gallot K Hajek J Sugawara H Till JA Deprest 2007 Lung tissue mechanics predict lung hypoplasia in a rabbit model for congenital diaphragmatic hernia Pediatr Pulmonol 42 6 505 512