Nonanimal alternatives for skin sensitization: Letter to the Editor

Toxicological Sciences

Volumn 106, Issue 2, 2008, Pages 572-574

  Roberts, David W ^a   Patlewicz, Grace Y ^b  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN;

ACCURACY; BINDING AFFINITY; BIOASSAY; CHEMICAL ANALYSIS; CHEMICAL REACTION; COMPUTER MODEL; COMPUTER PREDICTION; HUMAN; IN VITRO STUDY; INTERMETHOD COMPARISON; LETTER; LYMPH NODE ASSAY; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; SKIN SENSITIZATION; STRUCTURE ACTIVITY RELATION;

ANIMAL TESTING ALTERNATIVES; LOCAL LYMPH NODE ASSAY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SKIN;

EID: 56649089888     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn181     Document Type: Letter

References (8)

1. Aptula, A. O., and Roberts, D. W. (2006). Mechanistic applicability domains for nonanimal-based prediction of toxicological end points: General principles and application to reactive toxicity. Chem. Res. Toxicol. 19, 1097-1105.
2. Barratt, M. D., Basketter, D. A., and Roberts, D. W. (1997). Structure-activity relationships for contact hypersensitivity. In Allergic Contact Dermatitis. The Molecular Basis (J.-P. Lepoittevin, D. A. Basketter, A. Goosssens, and A.-T. Karlberg, Eds.), pp. 129-154. Springer, Heidelberg.
3. Basketter, D. A. (2008). Nonanimal alternatives for skin sensitization: A step forward? Toxicol. Sci. 102, 1-2.
4. Jowsey, I., Basketter, D. A., Westmoreland, C., and Kimber, I. (2006). A future approach to measuring relative skin sensitizing potency. J. Appl. Toxicol. 26, 341-350.
5. Natsch, A., and Emter, R. (2008). Skin sensitizers induce antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals. Toxicol. Sci. 102, 110-119.
6. OECD. (2004). OECD Principles for the Validation, for Regulatory Purposes, of (Q)SAR Models. Available at: http://www.oecd.org/ dataoecd/33/37/37849783.pdf. Accessed July 24, 2008.
7. Patlewicz, G., Aptula, A. O., Roberts, D. W., and Uriarte, E. (2008). A mini review of available (Q)SARs and expert systems for skin sensitisation. QSAR Comb. Sci. 27, 60-76.
8. Roberts, D. W., and Aptula, A. O. (2008). Determinants of skin sensitisation potential. J. Appl. Toxicol. 28, 377-387.