Gene expression study of IL10 family genes in vitiligo skin biopsies, peripheral blood mononuclear cells and sera

British Journal of Dermatology

Volumn 159, Issue 6, 2008, Pages 1275-1281

  Ratsep R ^a   Kingo, K ^a   Karelson, M ^a   Reimann, E ^a   Raud, K ^a   Silm, H ^a   Vasar, E ^a   Koks S ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b ESTONIAN UNIVERSITY OF LIFE SCIENCES   (Estonia)

Author keywords

Cytokine receptors; Cytokines; Gene expression; IL10 family; IL22; Vitiligo

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR ALPHA; INTERLEUKIN 10 RECEPTOR BETA; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 20 RECEPTOR ALPHA; INTERLEUKIN 22; INTERLEUKIN 22 RECEPTOR ALPHA1; INTERLEUKIN 24; INTERLEUKIN RECEPTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; MALE; MELANOCYTE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SERUM; SIGNAL TRANSDUCTION; SKIN BIOPSY; VITILIGO;

BIOPSY; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; LEUKOCYTES, MONONUCLEAR; POLYMERASE CHAIN REACTION; RNA, MESSENGER; VITILIGO;

EID: 56549123100     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08785.x     Document Type: Article

References (33)

1. Kent G, Al'Abadie M. Psychologic effects of vitiligo: a critical incident analysis. J Am Acad Dermatol 1996 35 : 895 8.
2. Kemp EH, Waterman EA, Weetman AP. Immunological pathomechanisms in vitiligo. Expert Rev Mol Med 2001 3 : 1 22.
3. Le Poole IC, Das PK, van den Wijngaard RM et al. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 1993 2 : 145 53.
4. Imokawa G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment Cell Res 2004 17 : 96 110.
5. Renauld JC. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev Immunol 2003 3 : 667 76.
6. Parrish-Novak J, Xu W, Brender T et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem 2002 277 : 47517 23.
7. Pestka S, Krause CD, Sarkar D et al. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol 2004 22 : 929 79.
8. Gerlini G, Tun-Kyi A, Dudli C et al. Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions. Am J Pathol 2004 165 : 1853 63.
9. Nemunaitis J, Fong T, Shabe P et al. Comparison of serum interleukin-10 (IL-10) levels between normal volunteers and patients with advanced melanoma. Cancer Invest 2001 19 : 239 47.
10. Blumberg H, Conklin D, Xu WF et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 2001 104 : 9 19.
11. Gallagher G, Dickensheets H, Eskdale J et al. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun 2000 1 : 442 50.
12. Romer J, Hasselager E, Norby PL et al. Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine A or calcipotriol. J Invest Dermatol 2003 121 : 1306 11.
13. Sabat R, Wallace E, Endesfelder S et al. IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases. Expert Opin Ther Targets 2007 11 : 601 12.
14. Lebedeva IV, Su ZZ, Chang Y et al. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene 2002 21 : 708 18.
15. Ellerhorst JA, Prieto VG, Ekmekcioglu S et al. Loss of MDA-7 expression with progression of melanoma. J Clin Oncol 2002 20 : 1069 74.
16. Wolk K, Kunz S, Asadullah K et al. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002 168 : 5397 402.
17. Kotenko SV, Izotova LS, Mirochnitchenko OV et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J Biol Chem 2001 276 : 2725 32.
18. Langer JA, Cutrone EC, Kotenko S. The class II cytokine receptor (CRF2) family: overview and patterns of receptor-ligand interactions. Cytokine Growth Factor Rev 2004 15 : 33 48.
19. Xu W, Presnell SR, Parrish-Novak J et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci USA 2001 98 : 9511 16.
20. Sharquie KE, Mehenna SH, Naji AA et al. Inflammatory changes in vitiligo: stage I and II depigmentation. Am J Dermatopathol 2004 26 : 108 12.
21. Birol A, Kisa U, Kurtipek GS et al. Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo. Int J Dermatol 2006 45 : 992 3.
22. Yu HS, Chang KL, Yu CL et al. Alterations in IL-6, IL-8, GM-CSF, TNF-alpha, and IFN-gamma release by peripheral mononuclear cells in patients with active vitiligo. J Invest Dermatol 1997 108 : 527 9.
23. Le Poole IC, Wankowicz-Kalinska A, van den Wijngaard RM et al. Autoimmune aspects of depigmentation in vitiligo. J Investig Dermatol Symp Proc 2004 9 : 68 72.
24. Honda Y, Okubo Y, Koga M. Relationship between levels of soluble interleukin-2 receptors and the types and activity of vitiligo. J Dermatol 1997 24 : 561 3.
25. Caixia T, Hongwen F, Xiran L. Levels of soluble interleukin-2 receptor in the sera and skin tissue fluids of patients with vitiligo. J Dermatol Sci 1999 21 : 59 62.
26. Zailaie MZ. Decreased proinflammatory cytokine production by peripheral blood mononuclear cells from vitiligo patients following aspirin treatment. Saudi Med J 2005 26 : 799 805.
27. Moretti S, Spallanzani A, Amato L et al. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 2002 15 : 87 92.
28. Andoh A, Zhang Z, Inatomi O et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 2005 129 : 969 84.
29. Wolk K, Witte E, Hoffmann U et al. IL-22 induces lipopolysaccharide- binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol 2007 178 : 5973 81.
30. Ikeuchi H, Kuroiwa T, Hiramatsu N et al. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum 2005 52 : 1037 46.
31. Wolk K, Kunz S, Witte E et al. IL-22 increases the innate immunity of tissues. Immunity 2004 21 : 241 54.
32. Boniface K, Bernard FX, Garcia M et al. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol 2005 174 : 3695 702.
33. Liang SC, Tan XY, Luxenberg DP et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006 203 : 2271 9.