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1
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38549152194
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Principles of bioactive lipid signalling: Lessons from sphingolipids
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A thorough review on sphingolipids metabolism, cellular localization, and mechanisms of action and regulation
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Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008; 9:139-150. A thorough review on sphingolipids metabolism, cellular localization, and mechanisms of action and regulation.
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(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
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Hannun, Y.A.1
Obeid, L.M.2
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2
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43049085142
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Sphingolipid signalling in the cardiovascular system: Good, bad or both?
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This review highlights the potential pathophysiologic connections of sphingolipids and their receptors with metabolic disorders and cardiovascular diseases
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Alewijnse AE, Peters SL. Sphingolipid signalling in the cardiovascular system: good, bad or both? Eur J Pharmacol 2008; 585:292-302. This review highlights the potential pathophysiologic connections of sphingolipids and their receptors with metabolic disorders and cardiovascular diseases.
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(2008)
Eur J Pharmacol
, vol.585
, pp. 292-302
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Alewijnse, A.E.1
Peters, S.L.2
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3
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38549093011
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Lipid signalling in disease
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A detailed and clear review on lipid signaling in inflammation, cancer, and metabolic syndrome. How this knowledge can be translated into therapeutical opportunities is discussed
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Wymann MP, Schneiter R. Lipid signalling in disease. Nat Rev Mol Cell Biol 2008; 9:162-176. A detailed and clear review on lipid signaling in inflammation, cancer, and metabolic syndrome. How this knowledge can be translated into therapeutical opportunities is discussed.
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(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 162-176
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Wymann, M.P.1
Schneiter, R.2
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4
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50949088162
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Lebman DA, Spiegel S. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. J Lipid Res 2008; 49:1388-1394. This is a focussed review on S1P, cytokines, and growth factors. The cross-talk between TGF-β and S1P signaling is discussed in detail.
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Lebman DA, Spiegel S. Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. J Lipid Res 2008; 49:1388-1394. This is a focussed review on S1P, cytokines, and growth factors. The cross-talk between TGF-β and S1P signaling is discussed in detail.
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5
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46949104885
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Takabe K, Paugh SW, Milstien S, Spiegel S. 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008; 60:181-195. A detailed review on S1P and its receptors. In addition, it gives some insight into S1P and S1P kinase-targeted therapies with the description of recent clinical trials using FTY720 (Fingolimod, an analog of S1P).
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Takabe K, Paugh SW, Milstien S, Spiegel S. 'Inside-out' signaling of sphingosine-1-phosphate: therapeutic targets. Pharmacol Rev 2008; 60:181-195. A detailed review on S1P and its receptors. In addition, it gives some insight into S1P and S1P kinase-targeted therapies with the description of recent clinical trials using FTY720 (Fingolimod, an analog of S1P).
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6
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42949105726
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Stiban J, Caputo L, Colombini M. Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins. J Lipid Res 2008; 49:625-634. This study supports the fascinating notion that ceramide, following its transfer from the endoplasmic reticulum to the mitochondria (a transfer so far uncharacterized), directly participates in the release of cytochrome c and the ensuing caspase activation.
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Stiban J, Caputo L, Colombini M. Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins. J Lipid Res 2008; 49:625-634. This study supports the fascinating notion that ceramide, following its transfer from the endoplasmic reticulum to the mitochondria (a transfer so far uncharacterized), directly participates in the release of cytochrome c and the ensuing caspase activation.
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8
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59449091508
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Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway
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Epub ahead of print
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Greenspon J, Li R, Xiao L, et al. Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. Dig Dis Sci 2008. [Epub ahead of print]
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(2008)
Dig Dis Sci
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Greenspon, J.1
Li, R.2
Xiao, L.3
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9
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51749104480
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Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells
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Epub ahead of print
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Heller R, Chang Q, Ehrlich G, et al. Overlapping and distinct roles for PI3Kβ and γ isoforms in S1P-induced migration of human and mouse endothelial cells. Cardiovasc Res 2008. [Epub ahead of print]
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(2008)
Cardiovasc Res
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Heller, R.1
Chang, Q.2
Ehrlich, G.3
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10
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0029070920
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Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells
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Kuwabara K, Ogawa S, Matsumoto M, et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci U S A 1995; 92:4606-4610.
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(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 4606-4610
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Kuwabara, K.1
Ogawa, S.2
Matsumoto, M.3
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11
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40049096040
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Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
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Schwalm S, Doll F, Romer I, et al. Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochem Biophys Res Commun 2008; 368:1020-1025.
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(2008)
Biochem Biophys Res Commun
, vol.368
, pp. 1020-1025
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Schwalm, S.1
Doll, F.2
Romer, I.3
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12
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0034672133
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Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions
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Murata N, Sato K, Kon J, et al. Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. Biochem J 2000; 352 (Pt 3):809-815.
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(2000)
Biochem J
, vol.352
, Issue.PART 3
, pp. 809-815
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Murata, N.1
Sato, K.2
Kon, J.3
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13
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54049103671
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HDL-associated sphingosine-1-phosphate promotes endothelial barrier function
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Argraves KM, Gazzolo PJ, Groh EM, et al. HDL-associated sphingosine-1-phosphate promotes endothelial barrier function. J Biol Chem 2008; 283:25074-25081.
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(2008)
J Biol Chem
, vol.283
, pp. 25074-25081
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Argraves, K.M.1
Gazzolo, P.J.2
Groh, E.M.3
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14
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46749085021
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Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin
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Gonzalez-Diez M, Rodriguez C, Badimon L, et al. Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. Thromb Haemost 2008; 100:119-126.
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(2008)
Thromb Haemost
, vol.100
, pp. 119-126
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Gonzalez-Diez, M.1
Rodriguez, C.2
Badimon, L.3
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15
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40449098552
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Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression
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Johann AM, Weigert A, Eberhardt W, et al. Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. J Immunol 2008; 180:1239-1248.
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(2008)
J Immunol
, vol.180
, pp. 1239-1248
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Johann, A.M.1
Weigert, A.2
Eberhardt, W.3
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16
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39649123726
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Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages
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Hammad SM, Crellin HG, Wu BX, et al. Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. Prostaglandins Other Lipid Mediat 2008; 85:107-114.
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(2008)
Prostaglandins Other Lipid Mediat
, vol.85
, pp. 107-114
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Hammad, S.M.1
Crellin, H.G.2
Wu, B.X.3
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17
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0032519925
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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF
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Fadok VA, Bratton DL, Konowal A, et al. Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J Clin Invest 1998; 101:890-898.
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(1998)
J Clin Invest
, vol.101
, pp. 890-898
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Fadok, V.A.1
Bratton, D.L.2
Konowal, A.3
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18
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52449129893
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Tolle M, Pawlak A, Schuchardt M, et al. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Arterioscler Thromb Vasc Biol 2008; 28:1542-1548. This study shows that HDLs block thrombin-induced MCP-1 production. This inhibitory effect can be mimicked by S1P and SPC but not by Apo-AI. Moreover, in S1P3 receptor knockout mice, the inhibiting effect of HDL on MCP-1 production is abolished. Interestingly, in scavenging receptor-BI knockout mice, MCP-1 induction upon thrombin stimulation is not blocked by HDL, suggesting that HDLs need to bind to the scavenging receptor-BI receptor to induce their inhibitory signals on MCP-1 production.
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Tolle M, Pawlak A, Schuchardt M, et al. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Arterioscler Thromb Vasc Biol 2008; 28:1542-1548. This study shows that HDLs block thrombin-induced MCP-1 production. This inhibitory effect can be mimicked by S1P and SPC but not by Apo-AI. Moreover, in S1P3 receptor knockout mice, the inhibiting effect of HDL on MCP-1 production is abolished. Interestingly, in scavenging receptor-BI knockout mice, MCP-1 induction upon thrombin stimulation is not blocked by HDL, suggesting that HDLs need to bind to the scavenging receptor-BI receptor to induce their inhibitory signals on MCP-1 production.
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19
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32144454172
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The many roles of chemokines and chemokine receptors in inflammation
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Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354:610-621.
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(2006)
N Engl J Med
, vol.354
, pp. 610-621
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Charo, I.F.1
Ransohoff, R.M.2
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20
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48749121214
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Gude DR, Alvarez SE, Spiegel S, et al. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a 'come-and-get-me' signal. FASEB J 2008; 22:2629-2638. In this work, the sphingosine kinase inhibitor, N,N-dimethylsphingosine was used in Jurkat cells. This inhibitor promoted apoptosis but unexpectedly induced the expression of SK1 but not of SK2, The resulting S1P secretion attracted monocytes. The augmentation in SK1 levels appears to be a consequence of apoptotic stress because caspase inhibitors efficiently blocked SK1 expression induced by the anticancer drug, doxorubicin. Earlier studies had already indicated that S1P, in response to different apoptotic stimuli, can be secreted by apoptotic Jurkat cells but this was reported to be SK2-dependent. It is, therefore, possible that distinct death stimuli will rely on different sphingosine kinase isoforms to produce and release S1P
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Gude DR, Alvarez SE, Spiegel S, et al. Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a 'come-and-get-me' signal. FASEB J 2008; 22:2629-2638. In this work, the sphingosine kinase inhibitor, N,N-dimethylsphingosine was used in Jurkat cells. This inhibitor promoted apoptosis but unexpectedly induced the expression of SK1 (but not of SK2). The resulting S1P secretion attracted monocytes. The augmentation in SK1 levels appears to be a consequence of apoptotic stress because caspase inhibitors efficiently blocked SK1 expression induced by the anticancer drug, doxorubicin. Earlier studies had already indicated that S1P, in response to different apoptotic stimuli, can be secreted by apoptotic Jurkat cells but this was reported to be SK2-dependent. It is, therefore, possible that distinct death stimuli will rely on different sphingosine kinase isoforms to produce and release S1P.
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