The relation of HOMA index with endothelial functions determined by flow mediated dilatation method among hyperglycemic patients

Indian Heart Journal

Volumn 59, Issue 6, 2007, Pages 463-467

  Karabaǧ, Turgut ^a,b   Kaya, Ahmet ^a   Yavuz, Safa ^a   Kaya, Coskun ^a   Koc, Fatih ^a   Yeter, Ekrem ^a  

^a SELCUK UNIVERSITY   (Turkey)

^b Meram Yeni Yol Caddesi   (Turkey)

Author keywords

Flow mediated dilatation; HOMA IR index; T2DM

Indexed keywords

CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; SULFONYLUREA; TRIACYLGLYCEROL;

ADULT; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; ENDOTHELIAL FUNCTION; FEMALE; FLOW MEDIATED DILATATION METHOD; HOMEOSTASIS MODEL ASSESSMENT OF INSULIN RESISTANCE INDEX; HUMAN; HYPEREMIA; HYPERGLYCEMIA; HYPERTENSION; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MATHEMATICAL AND STATISTICAL PROCEDURES; NON INSULIN DEPENDENT DIABETES MELLITUS; ULTRASOUND;

ANALYSIS OF VARIANCE; BLOOD FLOW VELOCITY; BLOOD GLUCOSE; BRACHIAL ARTERY; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; MALE; MIDDLE AGED;

EID: 56449127449     PISSN: 00194832     EISSN: 00194832     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Quyyumi AA. Endothelial function in health and disease: new insights into the genesis of cardiovascular disease. Am J Med 1998;105:32-39.
2. Ross R. Atherosclerosis - An inflammatory disease. Am Heart J 1999;138:419-420.
3. Steinberg HO, Chaker H, Leaming R, et al. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996;97:2601-2610.
4. Tooke JE. Microvascular function in human diabetes: a physiologic perspective. Diabetes 1995;44:721-726.
5. King GL, Wakasaki H. Theoretical mechanisms by which hyperglycemia and insulin resistance could cause cardiovascular diseases in diabetes. Diabetes Care 1999;22(Suppl-3):31-37.
6. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: A clinical perspective. Endocrine Rev 2001;22:36-52.
7. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;237:214-223.
8. Pacini G, Bergman RN: MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 1986;23:113-122.
9. Shen SW, Reaven GM, Farquhar JW: Comparison of impedance to insulin mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest 1970;49:2151-2160.
10. Korytkowski MT, Berga SL, Horwitz MJ: Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose. Metabolism 1995;44:1121-1125.
11. Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
12. Zeng G, Nystrom FH, Ravichandran LV, et al. Roles for insulin receptor, PI3 kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 2000;101:1539-1545.
13. Cardillo C, Kilcoyne CM, Nambi SS, et al. Vasodilator response to systemic but not to local hyperinsulinemia in the human forearm. Hypertension 1998;32:740-745.
14. Kuboki K, Jiang ZY, Takahara N, et al. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 2000;101:676-681.
15. Arcaro G, Cretti A, Balzano S, et al. Insulin causes endothelial dysfunction in humans. Sites and mechanisms. Circulation 2002;105:576-582.
16. Pinkney JH, Stehouwer CD, Coppack SW, et al. Endothelial dysfunction: cause of the insulin resistance syndrome. Diabetes 1997;46(Suppl.2):9-13.
17. Scherrer U, Randin D, Vollenweider P, et al. Nitric oxide release accounts for insulin's vascular effect in humans. J Clin Invest 1994;94:2511-2515.
18. Kotchen TA, Reddy S, Zhang HY. Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat. Am J Hypertens 1997;10:1020-1026.
19. Sakamoto S, Minami K, Niwa Y, et al. Effect of exercise training and food restriction on endothelium dependent relaxation of the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM. Diabetes 1998;47:82-86.
20. Shinozaki K, Kashiwagi A, Nishio Y, et al. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta. Diabetes 1999;48:2437-2445.
21. Shinozaki K, Nishio Y, Okamura T, et al. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in aortas of insulin-resistant rats. Circ Res 2000;87:566-573.
22. Setola E, Monti LD, Galluccio E, et al. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. European Journal of Endocrinology 2004;151:483-489.