Liquid Chromatographic Determination of Cocaine, Benzoylecgonine, and Cocaethylene in Whole Blood and Serum Samples with Diode-Array Detection

Journal of Chromatographic Science

Volumn 35, Issue 7, 1997, Pages 321-328

  Clauwaert, Karine M ^a   Van Bocxlaer, Jan F ^a   Lambert, Willy E ^a   De Leenheer, André P ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOYLECGONINE; COCAINE; DRUG DERIVATIVE; HOMOCOCAINE;

ARTICLE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LIQUID CHROMATOGRAPHY; METHODOLOGY;

CHROMATOGRAPHY, LIQUID; COCAINE; HUMANS; MOLECULAR STRUCTURE;

EID: 0031178303     PISSN: 00219665     EISSN: None     Source Type: Journal    
DOI: 10.1093/chromsci/35.7.321     Document Type: Article

References (21)

1. P.I. Jatlow. Drug of abuse profile: Cocaine. Clin. Chem. 33: 66B-71B (1987).
2. P.I. Jatlow. Cocaethylene: Pharmacologic activity and clinical significance. Ther. Drug. Monit. 15: 533-36 (1993).
3. P.R. Puopolo, P. Chamberlin, and J.G. Flood. Detection of cocaine and cocaethylene in serum emergency toxicology specimens. Clin. Chem. 38: 1838-42 (1992).
4. M. Nishikawa, K. Nakajima, M. Tatsuno, F. Kasuya, K. Igarashi, M. Fukui, and H. Tsuchihasi. The analysis of cocaine and its metabolites by liquid chromatography/atmospheric pressure chemical ionization-mass spectrometry (LC/APCI-MS). Forensic Sci. Int. 66: 149-58 (1994).
5. M. Balíková and J. Večerková. High-performance liquid chromatographic confirmation of cocaine and benzoylecgonine in biological samples using photodiode-array detection after toxicological screening. J. Chromatogr. 656: 267-73 (1994).
6. P. Bouis, G. Taccard, and U.A. Boelsterli. Determination of cocaine and norcocaine in plasma and cell cultures using high-performance liquid chromatography. J. Chromatogr. 526: 447-59 (1990).
7. J.A. Sandberg and G.D. Olsen. Microassay for the simultaneous determination of cocaine, norcocaine, benzoylecgonine and norbenzoylecgonine by high-performance liquid chromatography. J. Chromatogr. 525: 113-21 (1990).
8. R.L. Miller and C.L. DeVane. Determination of cocaine, benzoylecgonine and ecgonine methyl ester in plasma by reversed-phase high-performance liquid chromatography. J. Chromatogr. 570: 412-18 (1991).
9. P. Fernández, N. Lafuente, A.M. Bermejo, M. López-Rivadulla, and A. Cruz. HPLC determination of cocaine and benzoylecgonine in plasma and urine from drug abusers. J. Anal. Toxicol. 20: 224-28 (1996).
10. D.L. Phillips, I.R. Tebbett, and R.L. Bertholf. Comparison of HPLC and GC-MS for measurement of cocaine and metabolites in human urine. J. Anal. Toxicol. 20: 305-308 (1996).
11. D.S. Isenschmid, B.S. Levine, and Y.H. Caplan. A comprehensive study of the stability of cocaine and its metabolites. J. Anal. Toxicol. 13: 250-56 (1989).
12. R.C. Baselt. Stability of cocaine in biological fluids. J. Chromatogr. 268: 502-505 (1983).
13. Y. Liu, R.D. Budd, and E.C. Griesemer. Study on the stability of cocaine and benzoylecgonine, its major metabolite, in blood samples. J. Chromatogr. 248: 318-20 (1982).
14. W.C. Brogan, P.M. Kemp, R.O. Bost, D.B. Glamann, R.A. Lange, and L.D. Hillis. Collection and handling of clinical blood samples to assure the accurate measurement of cocaine concentration. J. Anal. Toxicol. 16: 152-54 (1992).
15. R.C. Baselt, D. Yoshikawa, J. Chang, and J. Li. Improved long-term stability of blood cocaine in evacuated collection tubes. J. Forensic Sci. 38: 935-37 (1993).
16. K. Clauwaert, W. Lambert, and A.P. De Leenheer. High performance liquid chromatography determination of cocaine and its main metabolites in biological samples: A review. J. Liq. Chromatogr. 18: 2097-114 (1995).
17. K.M. Clauwaert, J.F. Van Bocxlaer, W.E. Lambert, and A.P. De Leenheer. Analysis of cocaine, benzoylecgonine, and cocaethylene in urine by HPLC with diode array detection. Anal Chem. 68: 3021-28 (1995).
18. X.-H. Chen, J.-P. Franke, J. Wijsbeek, and R.A. de Zeeuw. Isolation of acidic, neutral, and basic drugs from whole blood using a single mixed-mode solid-phase extraction column. J. Anal. Toxicol. 16: 351-55 (1992).
19. P.G.M. Zweipfenning, A.H.C.M. Wilderink, P. Horsthuis, J.-P. Franke, and R.A. de Zeeuw. Toxicological analysis of whole blood samples by means of Bond-Elut Certify columns and gas chromatography with nitrogen-phosphorus detection. J. Chromatogr. 674: 87-95 (1994).
20. D.N. Bailey. Studies of cocaethylene (ethylcocaine) formation by human tissues in vitro. J. Anal. Toxicol. 18: 13-15 (1994).
21. D.N. Bailey. Cocapropylene (propylcocaine) formation by human liver in vitro. J. Anal. Toxicol. 19: 1-4 (1995).