Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups

Journal of Biological Chemistry

Volumn 279, Issue 41, 2004, Pages 42355-42358

  Holmborn, Katarina ^a   Ledin, Johan ^a   Smeds, Emanuel ^a   Eriksson, Inger ^a   Kusche Gullberg, Marion ^a   Kjellén, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELLS; ENZYMES; ORGANIC ACIDS; POLYSACCHARIDES;

GLUCURONIC ACID; N-DEACETYLASE/N-SULFOTRANSFERASE (NDST);

SULFUR COMPOUNDS;

EPIMERASE; GLUCOSAMINE; GLUCURONIC ACID; HEPARAN SULFATE; IDURONIC ACID; N DEACETYLASE N SULFOTRANSFERASE; N DEACETYLASE N SULFOTRANSFERASE 1; N DEACETYLASE N SULFOTRANSFERASE 2; POLYSACCHARIDE; SULFATE; SULFOTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL MATURATION; CELL TYPE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; EMBRYO CELL; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; STRUCTURE ANALYSIS; SULFATION;

AMIDOHYDROLASES; ANIMALS; BLASTOCYST; CARBOHYDRATE EPIMERASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; DNA, COMPLEMENTARY; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; GLUCOSAMINE; GLUCURONIC ACID; GLYCOSAMINOGLYCANS; HEPARITIN SULFATE; IDURONIC ACID; MICE; MICE, TRANSGENIC; NITROUS ACID; POLYSACCHARIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; SULFATES; SULFOTRANSFERASES; SULFUR;

ANIMALIA;

EID: 5644302242     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C400373200     Document Type: Article

References (25)

1. Esko, J. D., and Selleck, S. B. (2002) Annu. Rev. Biochem. 71, 435-471
2. Bullock, S. L., Fletcher, J. M., Beddington, R. S., and Wilson, V. A. (1998) Genes Dev. 12, 1894-1906
3. Ringvall, M., Ledin, J., Holmborn, K., van Kuppeveit, T., Ellin, F., Eriksson, I., Olofsson, A. M., Kjellen, L., and Forsberg, E. (2000) J. Biol. Chem. 275, 25926-25930
4. Li, J. P., Gong, F., Hagner-McWhirter, A., Forsberg, E., Abrink, M., Kisilevsky, R., Zhang, X., and Lindahl, U. (2003) J. Biol. Chem. 278, 28363-28366
5. Lin, X., Wei, G., Shi, Z., Dryer, L., Esko, J. D., Wells, D. E., and Matzuk, M. M. (2000) Dev. Biol. 224, 299-311
6. Forsberg, E., and Kjellen, L. (2001) J. Clin. Invest. 108, 175-180
7. Grobe, K., Ledin, J., Ringvall, M., Holmborn, K., Forsberg, E., Esko, J. D., and Kjellen, L. (2002) Biochim. Biophys. Acta 1573, 209-215
8. Merry, C. L., Bullock, S. L., Swan, D. C., Backen, A. C., Lyon, M., Beddington, R. S., Wilson, V. A., and Gallagher, J. T. (2001) J. Biol. Chem. 276, 35429-35434
9. Pikas, D. S., Eriksson, I., and Kjellen, L. (2000) Biochemistry 39, 4552-4558
10. van den Born, J., Gunnarsson, K., Bakker, M. A., Kjellen, L., Kusche-Gullberg, M., Maccarana, M., Berden, J. H., and Lindahl, U. (1995) J. Biol. Chem. 270, 31303-31309
11. Norgard-Sumnicht, K., and Varki, A. (1995) J. Biol. Chem. 270, 12012-12024
12. Westling, C., and Lindahl, U. (2002) J. Biol. Chem. 277, 49247-49255
13. Ledin, J., Staatz, W., Li, J. P., Gotte, M., Selleck, S., Kjellen, L., and Spillmann, D. (July 29, 2004) J. Biol. Chem. 10.1074/jbc.M405382200
14. Staatz, W. D., Toyoda, H., Kinoshita-Toyoda, A., Chhor, K., and Selleck, S. B. (2001) Methods Mol. Biol. 171, 41-52
15. Bengtsson, J., Eriksson, I., and Kjellen, L. (2003) Biochemistry 42, 2110-2115
16. Cheung, W. F., Eriksson, I., Kusche-Gullberg, M., Lindhal, U., and Kjellen, L. (1996) Biochemistry 35, 5250-5256
17. Shively, J. E., and Conrad, H. E. (1976) Biochemistry 15, 3943-3950
18. Riesenfeld, J., Hook, M., and Lindahl, U. (1982) J. Biol. Chem. 257, 421-425
19. Maccarana, M., Sakura, Y., Tawada, A., Yoshida, K., and Lindahl, U. (1996) J. Biol. Chem. 271, 17804-17810
20. Riesenfeld, J., and Roden, L. (1990) Anal. Biochem. 188, 383-389
21. Lindahl, U., Kusche-Gullberg, M., and Kjellen, L. (1998) J. Biol. Chem. 273, 24979-24982
22. Toyoda, H., Kinoshita-Toyoda, A., Fox, B., and Selleck, S. B. (2000) J. Biol. Chem. 275, 21856-21861
23. Smeds, E., Habuchi, H., Do, A. T., Hjertson, E., Grundberg, H., Kimata, K., Lindahl, U., and Kusche-Gullberg, M. (2003) Biochem. J. 372, 371-380
24. Habuchi, H., Tanaka, M., Habuchi, O., Yoshida, K., Suzuki, H., Ban, K., and Kimata, K. (2000) J. Biol. Chem. 275, 2859-2868
25. Aikawa, J., Grobe, K., Tsujimoto, M., and Esko, J. D. (2001) J. Biol. Chem. 276, 5876-5882