Evaluation of hepatoslanchnic circulation and intestinal oxygenation in dogs with a conditions that mimicked septic shock induced by continuous infusion of a low dose of lipopolysaccharide

American Journal of Veterinary Research

Volumn 65, Issue 10, 2004, Pages 1347-1354

  Sakaue, Yoko ^a   Nezu, Yoshinori ^a   Komori, Shinobu ^a   Hara, Yasushi ^a   Tagawa, Masahiro ^a   Ogawa, Ryo ^b  

^a NIPPON VETERINARY AND LIFE SCIENCE UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBON DIOXIDE TENSION; CONTINUOUS INFUSION; CONTROLLED STUDY; DOG DISEASE; FEMALE; HEART INDEX; HEMODYNAMICS; HEPATIC ARTERY; INTESTINE; LIVER CIRCULATION; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; MUCOSA; NONHUMAN; PORTAL VEIN BLOOD FLOW; SEPTIC SHOCK; SPLANCHNIC BLOOD FLOW; SYSTEMIC CIRCULATION; SYSTEMIC VASCULAR RESISTANCE; TISSUE BLOOD FLOW; TISSUE OXYGENATION; ANIMAL; ANIMAL DISEASE; BLOOD; BLOOD FLOW; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOG; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; LAPAROTOMY; METABOLISM; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR RESISTANCE; VASCULARIZATION;

ANIMALIA; CANIS FAMILIARIS; ESCHERICHIA COLI;

ANIMALS; BLOOD PRESSURE; CARBON DIOXIDE; DOG DISEASES; DOGS; INFUSIONS, INTRAVENOUS; INTESTINES; LAPAROTOMY; LIPOPOLYSACCHARIDES; OXYGEN; REGIONAL BLOOD FLOW; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION; STATISTICS, NONPARAMETRIC; VASCULAR RESISTANCE;

EID: 5644292229     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2004.65.1347     Document Type: Article

References (41)

1. Hardaway RM. A review of septic shock. Am Surg 2000;66:22-29.
2. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765-3777.
3. Oberholzer A, Oberholzer C, Moldawer LL. Cytokine signaling - regulation of the immune response in normal and critically ill states. Crit Care Med 2000;28(suppl 4):N3-N12.
4. Aosasa S, Ono S, Mochizuki H, et al. Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor α production of monocytes. Shock 2001;15:101-105.
5. Souter PJ, Thomas S, Hubbard AR, et al. Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole blood. Crit Care Med 2001;29:134-139.
6. Chan EL, Haudek SB, Giroir BP, et al. Human coronary endothelial cell activation by endotoxin is characterized by NF-κB activation and TNF-α synthesis. Shock 2001;16:349-354.
7. Bachschmid M, Thurau S, Zou MH, et al. Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation. FASEB J 2003;17:914-916.
8. Mitaka C, Hirata Y, Yokoyama K, et al. A selective inhibitor for inducible nitric oxide synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 2001;29:2156-2161.
9. Brandtzaeg P, Halstensen TS, Kett K, et al. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 1989;97:1562-1584.
10. Schmidt H, Martindale R. The gastrointestinal tract in critical illness: nutritional implications. Curr Opin Clin Nutr Metab Care 2003;6:587-591.
11. Mainous MR, Ertel W, Chaudry IH, et al. The gut: a cytokine-generating organ in systemic inflammation? Shock 1995;4:193-199.
12. Fong YM, Marano MA, Moldawer LL, et al. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 1990;85:1896-1904.
13. Dahn MS, Mitchell RA, Lange MP, et al. Hepatic metabolic response to injury and sepsis. Surgery 1995;117:520-530.
14. Lundgren O, Haglund U. The pathophysiology of the intestinal countercurrent exchanger. Life Sci 1978;23:1411-1422.
15. Revelly JP, Ayuse T, Brienza N, et al. Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 1996; 24:1345-1351.
16. Nezu Y, Tagawa M, Sakaue Y, et al. Kinetics of endotoxin concentration and tumor necrosis factor-α, interleukin-1β, and interleukin-6 activities in the systemic and portal circulation during small intestinal ischemia and reperfusion in dogs. Am J Vet Res 2002;63:1680-1686.
17. Deitch EA. Bacterial translocation or lymphatic drainage of toxic products from the gut: what is important in human beings? Surgery 2002;131:241-244.
18. Wang P, Ba ZF, Chaudry IH. Hepatic extraction of indocyanine green is depressed early in sepsis despite increased hepatic blood flow and cardiac output. Arch Surg 1991;126:219-224.
19. Deitch EA. Animal models of sepsis and shock: a review and lessons learned. Shock 1998;9:1-11.
20. Murphey ED, Traber DL. Cardiopulmonary and splanchnic blood flow during 48 hours of a continuous infusion of endotoxin in conscious pigs: a model of hyperdynamic shock. Shock 2000; 13:224-229.
21. 2 delivery in septic dogs. Am J Physiol 1995;268:H2017-H2023.
22. Reilly PM, MacGowan S, Miyachi M, et al. Mesenteric vasoconstriction in cardiogenic shock in pigs. Gastroenterology 1992;102:1968-1979.
23. 2 and its influence on the intramural pH in gastric mucosa. J Surg Res 1982;33:39-48.
24. De Backer D, Zhang H, Cherkhaoui S, et al. Effects of dobutamine on hepato-splanchnic hemodynamics in an experimental model of hyperdynamic endotoxic shock. Shock 2001;15:208-214.
25. 2) gradient in experimental endotoxin shock in swine - comparison of two methods. Intensive Care Med 2001;27:1923-1930.
26. De Backer D, Zhang H, Manikis P, et al. Regional effects of dobutamine in endotoxic shock. J Surg Res 1996;65:93-100.
27. Nezu Y, Sakaue Y, Hara Y, et al. Evaluation of intestinal intramucosal pH, arterial and portal venous blood gas values, and intestinal blood flow during small intestine ischemia and reperfusion in dogs. Am J Vet Res 2002;63:804-810.
28. Gannon BJ, Gore RW, Rogers PAW. Is there an anatomical basis for a vascular counter-current mechanism in rabbit and human intestinal villi? Biomed Res 1981;2:235-241.
29. Shepherd AP, Kiel JW. A model of countercurrent shunting of oxygen in the intestinal villus. Am J Physiol 1992; 262:H1136-H1142.
30. Bond JH, Levitt DG, Levitt MD. Quantitation of counter-current exchange during passive absorption from the dog small intestine: evidence for marked species differences in the efficiency of exchange. J Clin Invest 1977;59:308-318.
31. Yan W, Zhao K, Jiang Y, et al. Role of p38 MAPK in ICAM-1 expression of vascular endothelial cells induced by lipopolysaccharide. Shock 2002;17:433-438.
32. Chan EL, Haudek SB, Giroir BP, et al. Human coronary endothelial cell activation by endotoxin is characterized by NF-κB activation and TNF-α synthesis. Shock 2001;16:349-354.
33. Dore M, Sirois J. Regulation of P-selectin expression by inflammatory mediators in canine jugular endothelial cells. Vet Pathol 1996;33:662-671.
34. Okajima K. The role of leukocytes in disseminated intravascular coagulation associated with sepsis. Sepsis 1993;3:135-142.
35. Iba T, Kidokoro A, Yagi Y. The role of the endothelium in changes in procoagulant activity in sepsis. J Am Coll Surg 1998; 187:321-329.
36. Andonegui G, Bonder CS, Green F, et al. Endothelium-derived toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs. J Clin Invest 2003; 111:1011-1020.
37. Parker MM, Shelhamer JH, Bacharach SL, et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984;100:483-490.
38. Nemoto S, Vallejo J, Knuefermann P, et al. Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. Am J Physiol Heart Circ Physiol 2002; 282:H2316-H2323.
39. Mitaka C, Hirata Y, Yokoyama K, et al. Pathologic role of endothelin-1 in septic shock. J Cardiovasc Pharmacol 1998; 31(suppl 1):S233-S235.
40. Mitaka C, Hirata Y, Yokoyama K, et al. L-Canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothel in-1 concentrations in dogs with endotoxic shock. J Crit Care 2001; 16:17-23.
41. Yanase T, Enzan K, Mitsuhata H, et al. Dibutyryl cAMP improves systemic vasoconstriction caused by endotoxin in dogs. Shock 1996;5:284-288.