Asymptomatic cytomegalovirus infection is associated with increased risk of new-onset diabetes mellitus and impaired insulin release after renal transplantation

Diabetologia

Volumn 47, Issue 9, 2004, Pages 1550-1556

  Hjelmesaeth J ^a,b   Sagedal, S ^a   Hartmann, A ^a   Rollag, H ^a   Egeland, T ^a   Hagen, M ^a   Nordal, K P ^a   Jenssen, T ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b VESTFOLD HOSPITAL TRUST   (Norway)

Author keywords

Cyclosporine; Cytomegalovirus infections; Diabetes mellitus; Etiology; Glucocorticoids; Glucose tolerance test; Insulin; Kidney transplantation

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; CYTOMEGALOVIRUS ANTIBODY; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; INSULIN; MYCOPHENOLIC ACID; PREDNISOLONE; TACROLIMUS;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DIABETES MELLITUS; FEMALE; GLUCOSE TOLERANCE; HUMAN; HYPERGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RELEASE; INSULIN SENSITIVITY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; PRIORITY JOURNAL;

ANTIGENS, VIRAL; BLOOD GLUCOSE; CYTOMEGALOVIRUS INFECTIONS; DIABETES MELLITUS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INSULIN; KIDNEY TRANSPLANTATION; MALE; ODDS RATIO; POSTOPERATIVE COMPLICATIONS;

EID: 5644261372     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1499-z     Document Type: Article

References (31)

1. Jaeckel E, Mann M, von Herrath M (2002) Viruses and diabetes. Ann NY Acad Sci 958:7-25
2. Mehta SH, Brancati FL, Sulkowski MS, Strathdee SA, Szklo M, Thomas DL (2000) Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 133:592-599
3. Bloom RD, Rao V, Weng F, Grossman RA, Cohen D, Mange KC (2002) Association of hepatitis C with posttransplant diabetes in renal transplant patients on tacrolimus. J Am Soc Nephrol 13:1374-1380
4. Dubé MP (2000) Disorders of glucose metabolism in patients infected with human immunodeficiency virus. Clin Infect Dis 31:1467-1475
5. Pak CY, Eun HM, McArthur RG, Yoon JW (1988) Association of cytomegalovirus infection with autoimmune type 1 diabetes. Lancet 2:1-4
6. Hiemstra HS, Schloot NC, van Veelen PA et al. (2001) Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc Natl Acad Sci USA 98:3988-3991
7. Jenson AB, Rosenberg HS, Notkins AL (1980) Pancreatic islet-cell damage in children with fatal viral infections. Lancet 2:354-358
8. Lohr JM, Oldstone MB (1990) Detection of cytomegalovirus nucleic acid sequences in pancreas in type 2 diabetes. Lancet 336:644-648
9. Hjelmesæth J, Hartmann A, Kofstad J et al. (1997) Glucose intolerance after renal transplantation depends upon prednisolone dose and recipient age. Transplantation 64:979-983
10. Sagedal S, Nordal KP, Hartmann A et al. (2000) A prospective study of the natural course of cytomegalovirus infection and disease in renal allograft recipients. Transplantation 70:1166-1174
11. Flodstrom M, Tsai D, Fine C, Maday A, Sarvetnick N (2003) Diabetogenic potential of human pathogens uncovered in experimentally permissive β-cells. Diabetes 52:2025-2034
12. Ekstrand AV, Eriksson JG, Grönhagen-Riska C, Ahonen PJ, Groop LC (1992) Insulin resistance and insulin deficiency in the pathogenesis of posttransplant diabetes in man. Transplantation 53:563-569
13. Midtvedt K, Hartmann A, Hjelmesæth J, Lund K, Bjerkely BL (1998) Insulin resistance is a common denominator of post-transplant diabetes mellitus and impaired glucose tolerance in renal transplant recipients. Nephrol Dial Transplant 13:427-431
14. Nam JH, Mun JI, Kim SI et al. (2001) β-cell dysfunction rather than insulin resistance is the main contributing factor for the development of postrenal transplantation diabetes mellitus. Transplantation 71:1417-1423
15. Hjelmesæth J, Midtvedt K, Jenssen T, Hartmann A (2001) Insulin resistance after renal transplantation: impact of immunosuppressive and antihypertensive therapy. Diabetes Care 24:2121-2126
16. Lambilotte C, Gilon P, Henquin JC (1997) Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets. J Clin Invest 99:414-423
17. Hjelmesæth J, Jenssen T, Hagen M, Egeland T, Hartmann A (2003) Determinants of insulin secretion after renal transplantation. Metabolism 52:573-578
18. Rollag H, Sagedal S, Holter E, Degre M, Ariansen S, Nordal KP (1998) Diagnosis of cytomegalovirus infection in kidney transplant recipients by a quantitative RNA-DNA hybrid capture assay for cytomegalovirus DNA in leukocytes. Eur J Clin Microbiol Infect Dis 17:124-127
19. Ljungman P, Griffiths P, Paya C (2002) Definition of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34:1094-1097
20. Birkeland KI, Kilhovd B, Thorsby P et al. (2003) Heterogeneity of non-insulin-dependent diabetes expressed as variability in insulin sensitivity, β-cell function and cardiovascular risk profile. Diabet Med 20:37-45
21. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2000) Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 23 [Suppl 1]:S4-S19
22. Stumvoll M, Mitrakou A, Pimenta W et al. (2000) Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23:295-301
23. Stumvoll M, Van Haeften T, Pritsche A, Gerich J (2001) Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care 24:796-797
24. Stumvoll M, Mitrakou A, Pimenta W et al. (2000) Assessment of insulin secretion from the oral glucose tolerance test in white patients with type 2 diabetes. Diabetes Care 23:1440-1441
25. Ivarsson SA, Lindberg B, Nilsson KO, Ahlfors K, Svanberg L (1993) The prevalence of type 1 diabetes mellitus at follow-up of Swedish infants congenitally infected with cytomegalovirus. Diabet Med 10:521-523
26. Nordøy I, Müller F, Nordal KP et al. (2000) The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients. J Infect Dis 181:51-57
27. Moller DE (2000) Potential role of TNF-α in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 11:212-217
28. Hjelmesæth J, Hartmann A, Kofstad J, Egeland T, Stenstrøm J, Fauchald P (2001) Tapering off prednisolone and cyclosporin the first year after transplantation: the effect on glucose tolerance. Nephrol Dial Transplant 16:829-835
29. Lowance D, Neumayer HH, Legendre CM et al. (1999) Valacyclovir for the prevention of cytomegalovirus disease after renal transplantation. N Engl J Med 340:1462-1470
30. Künzle N, Petignat C, Francioli P et al. (2000) Preemptive treatment approach to cytomegalovirus (CMV) infection in solid organ transplant patients: relationship between compliance with the guidelines and prevention of CMV morbidity. Transpl Infect Dis 2:118-126
31. Sagedal S, Nordal KP, Hartmann A et al. (2003) Preemptive therapy of CMVpp65 antigen positive renal transplant recipients with oral ganciclovir: a randomized, comparative study. Nephrol Dial Transplant 18:1899-1908