An efficient synthesis of substituted pyrroles with the aid of a low-valent titanium reagent

Synlett

Volumn , Issue 12, 2004, Pages 2239-2241

  Shi, Daqing ^a,b,c   Shi, Chuling ^a   Wang, Xiangshan ^a,b   Zhuang, Qiya ^a,b   Tu, Shujiang ^a,b   Hu, Hongwen ^c  

^a JIANGSU NORMAL UNIVERSITY   (China)

^b JIANGSU NORMAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Low valent titanium reagent; Pyrrole; Synthesis

Indexed keywords

1,3 DIKETONE; KETONE DERIVATIVE; PYRROLE DERIVATIVE; REAGENT; TITANIUM; TITANIUM DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; POLYMERIZATION; REACTION ANALYSIS; SUBSTITUTION REACTION; SYNTHESIS;

EID: 5644223408     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-831295     Document Type: Article

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36. 4), and the solvent was removed to give the crude product, which was purified by column chromatography [silica gel, acetone-petroleum ether (bp 60-90°C), 1:6] to give pure 3.
37. 2: C, 81.10; H, 5.96; N, 3.94%. Found: C, 81.28; H, 5.82; N, 3.85%.
38. -1. Intensity data were collected on a Siemens P4 diffractometer with graphite monochromated MoKα radiation (λ = 0.71073 Å), using scan mode with 1.76°<0<25.50°. 4205 unique reflections were measured and 2267 reflections with I>2σ(I) were used in the refinement. The structure was solved by direct methods and expanded using Fourier techniques. The final refinement was converged to R = 0.0387 and wR = 0.0793.