메뉴 건너뛰기




Volumn 12, Issue 11, 2008, Pages 1377-1387

Novel targets for myeloma bone disease

Author keywords

Bone disease; Myeloma; Novel treatments; Osteoblast; Osteoclast

Indexed keywords

1 [5 CHLORO 2 [2 [4 (4 FLUOROBENZYL) 2 METHYL 1 PIPERAZINYL] 2 OXOETHOXY]PHENYL]UREA; 3 (4 AMINO 1,3 DIHYDRO 1,3 DIOXO 2H ISOINDOL 2 YL)GLUTARIMIDE; BLOCKING ANTIBODY; BORTEZOMIB; CHEMOKINE RECEPTOR ANTAGONIST; COLONY STIMULATING FACTOR RECEPTOR; DENOSUMAB; DEXAMETHASONE; DICKKOPF HOMOLOG 1; DICKKOPF HOMOLOG 1 ANTIBODY; DOXORUBICIN; FRIZZLED PROTEIN; I KAPPA B KINASE INHIBITOR; IMMUNOMODULATING AGENT; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 7; LENALIDOMIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MELPHALAN; MLN 3897; NEUTRALIZING ANTIBODY; NOTCH RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR ANTIBODY; PHOSPHATE; PROTEIN INHIBITOR; SECRETED FRIZZLED RELATED PROTEIN 2; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 56249122936     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.12.11.1377     Document Type: Review
Times cited : (28)

References (85)
  • 3
    • 18144451007 scopus 로고    scopus 로고
    • New insights in myeloma-induced osteolysis
    • Barille-Nion S, Bataille R. New insights in myeloma-induced osteolysis. Leuk Lymphoma 2003;44:1463-7
    • (2003) Leuk Lymphoma , vol.44 , pp. 1463-1467
    • Barille-Nion, S.1    Bataille, R.2
  • 4
    • 4143082697 scopus 로고    scopus 로고
    • New insight in the mechanism of osteoclast activation and formation in multiple myeloma: Focus on the receptor activator of NF-κB ligand (RANKL)
    • Giuliani N, Colla S, Rizzoli V. New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-κB ligand (RANKL). Exp Hematol 2004; 32:685-91
    • (2004) Exp Hematol , vol.32 , pp. 685-691
    • Giuliani, N.1    Colla, S.2    Rizzoli, V.3
  • 5
    • 1542330894 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis 2004;32:290-2
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 290-292
    • Roodman, G.D.1
  • 6
    • 0024786736 scopus 로고
    • Mechanisms of bone destruction in multiple myeloma: The importance of an unbalanced process in determining the severity of lytic bone disease
    • Bataille R, Chappard D, Marcelli C, et al. Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease. J Clin Oncol 1989;7:1909-14
    • (1989) J Clin Oncol , vol.7 , pp. 1909-1914
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 7
    • 0025678591 scopus 로고
    • Osteoblast stimulation in multiple myeloma lacking lytic bone lesions
    • Bataille R, Chappard D, Marcelli C, et al. Osteoblast stimulation in multiple myeloma lacking lytic bone lesions. Br J Haematol 1990;76:484-7
    • (1990) Br J Haematol , vol.76 , pp. 484-487
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 8
    • 0030939407 scopus 로고    scopus 로고
    • Abnormal bone turnover in monoclonal gammopathy of undetermined significance: Analyses of type I collagen telopeptide, osteocalcin, bone-specific alkaline phosphatase and propeptides of type I and type III procollagens
    • Vejlgaard T, Abildgaard N, Jans H, et al. Abnormal bone turnover in monoclonal gammopathy of undetermined significance: analyses of type I collagen telopeptide, osteocalcin, bone-specific alkaline phosphatase and propeptides of type I and type III procollagens. Eur J Haematol 1997;58:104-8
    • (1997) Eur J Haematol , vol.58 , pp. 104-108
    • Vejlgaard, T.1    Abildgaard, N.2    Jans, H.3
  • 9
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350:1655-64
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 10
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001;98:11581-6
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3
  • 11
    • 0036181668 scopus 로고    scopus 로고
    • Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    • Yaccoby S, Pearse RN, Johnson CL, et al. Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 2002;116:278-90
    • (2002) Br J Haematol , vol.116 , pp. 278-290
    • Yaccoby, S.1    Pearse, R.N.2    Johnson, C.L.3
  • 12
    • 56249137685 scopus 로고    scopus 로고
    • An open label phase II trial of Denosumab in the treatment of relapsed or plateau-phase myeloma
    • Vij R, Horvath N, Spencer A, et al. An open label phase II trial of Denosumab in the treatment of relapsed or plateau-phase myeloma. Blood 2007;118:1054A
    • (2007) Blood , vol.118
    • Vij, R.1    Horvath, N.2    Spencer, A.3
  • 13
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C, Hjertner O, Abildgaard N, et al. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 2001;98:2269-71
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner, O.2    Abildgaard, N.3
  • 14
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J, et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 2001;98:3534-40
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3
  • 15
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE, et al. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 2003;97:887-92
    • (2003) Cancer , vol.97 , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3
  • 16
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001;98:3527-33
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3
  • 17
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O, Heider U, Zavrski I, et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101:2094-8
    • (2003) Blood , vol.101 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3
  • 18
    • 0037097587 scopus 로고    scopus 로고
    • Immunocytochemistry reveals RANKL expression of myeloma cells
    • Sezer O, Heider U, Jakob C, et al. Immunocytochemistry reveals RANKL expression of myeloma cells. Blood 2002;99:4646-7
    • (2002) Blood , vol.99 , pp. 4646-4647
    • Sezer, O.1    Heider, U.2    Jakob, C.3
  • 19
    • 1542720384 scopus 로고    scopus 로고
    • Cancer and the microenvironment: Myeloma-osteoclast interactions as a model
    • Yaccoby S, Wezeman MJ, Henderson A, et al. Cancer and the microenvironment: myeloma-osteoclast interactions as a model. Cancer Res 2004;64:2016-23
    • (2004) Cancer Res , vol.64 , pp. 2016-2023
    • Yaccoby, S.1    Wezeman, M.J.2    Henderson, A.3
  • 20
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, et al. Soluble receptor activator of nuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 2003;102:1064-9
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 21
    • 0030056856 scopus 로고    scopus 로고
    • The role of MIP-1α in inflammation and hematopoiesis
    • Cook DN. The role of MIP-1α in inflammation and hematopoiesis. J Leukoc Biol 1996;59:61-6
    • (1996) J Leukoc Biol , vol.59 , pp. 61-66
    • Cook, D.N.1
  • 22
    • 0037105599 scopus 로고    scopus 로고
    • Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
    • Abe M, Hiura K, Wilde J, et al. Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma. Blood 2002;100:2195-202
    • (2002) Blood , vol.100 , pp. 2195-2202
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 23
    • 0028989486 scopus 로고
    • Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts
    • Fuller K, Owens JM, Chambers TJ. Macrophage inflammatory protein-1 alpha and IL-8 stimulate the motility but suppress the resorption of isolated rat osteoclasts. J Immunol 1995;154:6065-72
    • (1995) J Immunol , vol.154 , pp. 6065-6072
    • Fuller, K.1    Owens, J.M.2    Chambers, T.J.3
  • 24
    • 0030903039 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow: Its role in regulation of hematopoiesis and osteoclast recruitment
    • Kukita T, Nomiyama H, Ohmoto Y, et al. Macrophage inflammatory protein-1 alpha (LD78) expressed in human bone marrow: its role in regulation of hematopoiesis and osteoclast recruitment. Lab Invest 1997;76:399-406
    • (1997) Lab Invest , vol.76 , pp. 399-406
    • Kukita, T.1    Nomiyama, H.2    Ohmoto, Y.3
  • 25
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi SJ, Cruz JC, Craig F, et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 2000;96:671-5
    • (2000) Blood , vol.96 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3
  • 26
    • 1842505726 scopus 로고    scopus 로고
    • Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1α and MIP-1β correlates with lytic bone lesions in patients with multiple myeloma
    • Hashimoto T, Abe M, Oshima T, et al. Ability of myeloma cells to secrete macrophage inflammatory protein (MIP)-1α and MIP-1β correlates with lytic bone lesions in patients with multiple myeloma. Br J Haematol 2004;125:38-41
    • (2004) Br J Haematol , vol.125 , pp. 38-41
    • Hashimoto, T.1    Abe, M.2    Oshima, T.3
  • 27
    • 0037219741 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM
    • Uneda S, Hata H, Matsuno F, et al. Macrophage inflammatory protein-1 alpha is produced by human multiple myeloma (MM) cells and its expression correlates with bone lesions in patients with MM. Br J Haematol 2003;120:53-5
    • (2003) Br J Haematol , vol.120 , pp. 53-55
    • Uneda, S.1    Hata, H.2    Matsuno, F.3
  • 28
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease
    • Choi SJ, Oba Y, Gazitt Y, et al. Antisense inhibition of macrophage inflammatory protein 1-α blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001;108:1833-41
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3
  • 29
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    • Oyajobi BO, Franchin G, Williams PJ, et al. Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 2003;102:311-9
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3
  • 30
    • 13844317079 scopus 로고    scopus 로고
    • MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells
    • Oba Y, Lee JW, Ehrlich LA, et al. MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 2005;33:272-8
    • (2005) Exp Hematol , vol.33 , pp. 272-278
    • Oba, Y.1    Lee, J.W.2    Ehrlich, L.A.3
  • 31
    • 36348988548 scopus 로고    scopus 로고
    • MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts
    • Vallet S, Raje N, Ishitsuka K, et al. MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. Blood 2007;110:3744-52
    • (2007) Blood , vol.110 , pp. 3744-3752
    • Vallet, S.1    Raje, N.2    Ishitsuka, K.3
  • 32
    • 33751190044 scopus 로고    scopus 로고
    • Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: A study in the 5TMM model
    • Menu E, De Leenheer E, De Raeve H, et al. Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model. Clin Exp Metastasis 2006;23:291-300
    • (2006) Clin Exp Metastasis , vol.23 , pp. 291-300
    • Menu, E.1    De Leenheer, E.2    De Raeve, H.3
  • 33
    • 1542313900 scopus 로고    scopus 로고
    • IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells
    • Lee JW, Chung HY, Ehrlich LA, et al. IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood 2004;103:2308-15
    • (2004) Blood , vol.103 , pp. 2308-2315
    • Lee, J.W.1    Chung, H.Y.2    Ehrlich, L.A.3
  • 34
    • 85014285855 scopus 로고    scopus 로고
    • Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells
    • Cheung WC, Van Ness B. Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cells. Leukemia 2002;16:1182-8
    • (2002) Leukemia , vol.16 , pp. 1182-1188
    • Cheung, W.C.1    Van Ness, B.2
  • 35
    • 0029051328 scopus 로고
    • Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo
    • de la Mata J, Uy HL, Guise TA, et al. Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 1995;95:2846-52
    • (1995) J Clin Invest , vol.95 , pp. 2846-2852
    • de la Mata, J.1    Uy, H.L.2    Guise, T.A.3
  • 36
    • 0030889389 scopus 로고    scopus 로고
    • Interaction of tumor and hosT cells with adhesion and extracellular matrix molecules in the development of multiple myeloma
    • Teoh G, Anderson KG. Interaction of tumor and hosT cells with adhesion and extracellular matrix molecules in the development of multiple myeloma. Hematol Oncol Clin North Am 1997;11:27-42
    • (1997) Hematol Oncol Clin North Am , vol.11 , pp. 27-42
    • Teoh, G.1    Anderson, K.G.2
  • 37
    • 33644866173 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma
    • Yasui H, Hideshima T, Richardson PG, et al. Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma. Br J Haematol 2006;132:385-97
    • (2006) Br J Haematol , vol.132 , pp. 385-397
    • Yasui, H.1    Hideshima, T.2    Richardson, P.G.3
  • 38
    • 11144358653 scopus 로고    scopus 로고
    • Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells
    • Jundt F, Probsting KS, Anagnostopoulos I, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood 2004;103:3511-5
    • (2004) Blood , vol.103 , pp. 3511-3515
    • Jundt, F.1    Probsting, K.S.2    Anagnostopoulos, I.3
  • 39
    • 41349095228 scopus 로고    scopus 로고
    • Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy
    • Nefedova Y, Sullivan DM, Bolick SC, et al. Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy. Blood 2008;111:2220-9
    • (2008) Blood , vol.111 , pp. 2220-2229
    • Nefedova, Y.1    Sullivan, D.M.2    Bolick, S.C.3
  • 40
    • 57849158165 scopus 로고    scopus 로고
    • Notch inhibition blocks multiple myeloma cell-induced osteoclast activation
    • June 5, doi:10.1038/leu.2008.138
    • Schwatzer R, Kaiser M, Acikgoez O, et al. Notch inhibition blocks multiple myeloma cell-induced osteoclast activation. Leukemia 2008. Published online 2008 June 5, doi:10.1038/leu.2008.138
    • (2008) Leukemia 2008. Published online
    • Schwatzer, R.1    Kaiser, M.2    Acikgoez, O.3
  • 41
    • 33744768634 scopus 로고    scopus 로고
    • Regulation of osteoclast differentiation
    • Roodman GD. Regulation of osteoclast differentiation. Ann NY Acad Sci 2006;1068:100-9
    • (2006) Ann NY Acad Sci , vol.1068 , pp. 100-109
    • Roodman, G.D.1
  • 42
    • 33846009075 scopus 로고    scopus 로고
    • Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease
    • Kurihara N, Hiruma Y, Zhou H, et al. Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease. J Clin Invest 2007;117:133-42
    • (2007) J Clin Invest , vol.117 , pp. 133-142
    • Kurihara, N.1    Hiruma, Y.2    Zhou, H.3
  • 43
    • 56249116762 scopus 로고    scopus 로고
    • Hiruma Y, Honjo T, Jelinek D, et al. Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. Blood 2008
    • Hiruma Y, Honjo T, Jelinek D, et al. Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. Blood 2008
  • 45
    • 0032930729 scopus 로고    scopus 로고
    • Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice
    • Hjorth-Hansen H, Seifert MF, Borset M, et al. Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice. J Bone Miner Res 1999;14:256-63
    • (1999) J Bone Miner Res , vol.14 , pp. 256-263
    • Hjorth-Hansen, H.1    Seifert, M.F.2    Borset, M.3
  • 46
    • 4143119930 scopus 로고    scopus 로고
    • Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells
    • Silvestris F, Cafforio P, Calvani N, et al. Impaired osteoblastogenesis in myeloma bone disease: role of upregulated apoptosis by cytokines and malignant plasma cells. Br J Haematol 2004;126:475-86
    • (2004) Br J Haematol , vol.126 , pp. 475-486
    • Silvestris, F.1    Cafforio, P.2    Calvani, N.3
  • 47
    • 0024593494 scopus 로고
    • Does myeloma secrete an osteoblast inhibiting factor?
    • Evans CE, Galasko CS, Ward C. Does myeloma secrete an osteoblast inhibiting factor? J Bone Joint Surg Br 1989;71:288-90
    • (1989) J Bone Joint Surg Br , vol.71 , pp. 288-290
    • Evans, C.E.1    Galasko, C.S.2    Ward, C.3
  • 48
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling in osteoblasts and bone diseases. Gene 2004;341:19-39
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 49
    • 0037474465 scopus 로고    scopus 로고
    • Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction
    • Bain G, Muller T, Wang X, et al. Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction. Biochem Biophys Res Commun 2003;301:84-91
    • (2003) Biochem Biophys Res Commun , vol.301 , pp. 84-91
    • Bain, G.1    Muller, T.2    Wang, X.3
  • 50
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-94
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 51
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang YW, Chen Y, Stephens O, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008;112:196-207
    • (2008) Blood , vol.112 , pp. 196-207
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3
  • 52
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006;119:1728-31
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3
  • 53
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M, Mieth M, Liebisch P, et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Haematol 2008;80:490-4
    • (2008) Eur J Haematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3
  • 54
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • Giuliani N, Colla S, Morandi F, et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 2005;106:2472-83
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3
  • 55
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, Zhan F, et al. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007;109(5):2106-11
    • (2007) Blood , vol.109 , Issue.5 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3
  • 57
    • 0035437195 scopus 로고    scopus 로고
    • Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays
    • De Vos J, Couderc G, Tarte K, et al. Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays. Blood 2001;98:771-80
    • (2001) Blood , vol.98 , pp. 771-780
    • De Vos, J.1    Couderc, G.2    Tarte, K.3
  • 58
    • 34548008809 scopus 로고    scopus 로고
    • Production of Wnt inhibitors by myeloma cells: Potential effects on canonical Wnt pathway in the bone microenvironment
    • Giuliani N, Morandi F, Tagliaferri S, et al. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment. Cancer Res 2007;67:7665-74
    • (2007) Cancer Res , vol.67 , pp. 7665-7674
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 59
    • 10744226505 scopus 로고    scopus 로고
    • Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis
    • Davies FE, Dring AM, Li C, et al. Insights into the multistep transformation of MGUS to myeloma using microarray expression analysis. Blood 2003;102:4504-11
    • (2003) Blood , vol.102 , pp. 4504-4511
    • Davies, F.E.1    Dring, A.M.2    Li, C.3
  • 60
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I, et al. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood 2005;106:1407-14
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3
  • 61
    • 0036897349 scopus 로고    scopus 로고
    • Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    • Weitzmann MN, Roggia C, Toraldo G, et al. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 2002;110:1643-50
    • (2002) J Clin Invest , vol.110 , pp. 1643-1650
    • Weitzmann, M.N.1    Roggia, C.2    Toraldo, G.3
  • 62
    • 37149016951 scopus 로고    scopus 로고
    • Myeloma cells and bone marrow osteoblast interactions: Role in the development of osteolytic lesions in multiple myeloma
    • Giuliani N, Rizzoli V. Myeloma cells and bone marrow osteoblast interactions: role in the development of osteolytic lesions in multiple myeloma. Leuk Lymphoma 2007;48:2323-9
    • (2007) Leuk Lymphoma , vol.48 , pp. 2323-2329
    • Giuliani, N.1    Rizzoli, V.2
  • 63
    • 9044219839 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L, et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 1996;334:488-93
    • (1996) N Engl J Med , vol.334 , pp. 488-493
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 65
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE, et al. A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006;12:1221-8
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3
  • 66
    • 33746328060 scopus 로고    scopus 로고
    • Proteasome inhibition in multiple myeloma
    • Kropff M, Bisping G, Wenning D, et al. Proteasome inhibition in multiple myeloma. Eur J Cancer 2006;42:1623-39
    • (2006) Eur J Cancer , vol.42 , pp. 1623-1639
    • Kropff, M.1    Bisping, G.2    Wenning, D.3
  • 67
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
    • Garrett IR, Chen D, Gutierrez G, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest 2003;111:1771-82
    • (2003) J Clin Invest , vol.111 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3
  • 68
    • 27744557499 scopus 로고    scopus 로고
    • Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma
    • Zangari M, Esseltine D, Lee CK, et al. Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma. Br J Haematol 2005;131:71-3
    • (2005) Br J Haematol , vol.131 , pp. 71-73
    • Zangari, M.1    Esseltine, D.2    Lee, C.K.3
  • 69
    • 0023946023 scopus 로고
    • Management of refractory myeloma: A review
    • Buzaid AC, Durie BG. Management of refractory myeloma: a review. J Clin Oncol 1988;6:889-905
    • (1988) J Clin Oncol , vol.6 , pp. 889-905
    • Buzaid, A.C.1    Durie, B.G.2
  • 70
    • 37249075921 scopus 로고    scopus 로고
    • Glucocorticoids and the osteoclast
    • Kim HJ, Zhao H, Kitaura H, et al. Glucocorticoids and the osteoclast. Ann NY Acad Sci 2007;1116:335-9
    • (2007) Ann NY Acad Sci , vol.1116 , pp. 335-339
    • Kim, H.J.1    Zhao, H.2    Kitaura, H.3
  • 71
    • 33746786028 scopus 로고    scopus 로고
    • Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment
    • Heider U, Kaiser M, Muller C, et al. Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment. Eur J Haematol 2006;77:233-8
    • (2006) Eur J Haematol , vol.77 , pp. 233-238
    • Heider, U.1    Kaiser, M.2    Muller, C.3
  • 72
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E, Heath DJ, Rahemtulla A, et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-κB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 2006;135:688-92
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3
  • 73
    • 34548029349 scopus 로고    scopus 로고
    • Myeloma bone disease and proteasome inhibition therapies
    • Terpos E, Sezer O, Croucher P, et al. Myeloma bone disease and proteasome inhibition therapies. Blood 2007;110:1098-104
    • (2007) Blood , vol.110 , pp. 1098-1104
    • Terpos, E.1    Sezer, O.2    Croucher, P.3
  • 74
    • 34347400592 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients
    • Giuliani N, Morandi F, Tagliaferri S, et al. The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood 2007;110:334-8
    • (2007) Blood , vol.110 , pp. 334-338
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 75
    • 34848853850 scopus 로고    scopus 로고
    • Stimulation of new bone formation by the proteasome inhibitor, bortezomib: Implications for myeloma bone disease
    • Oyajobi BO, Garrett IR, Gupta A, et al. Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease. Br J Haematol 2007;139:434-8
    • (2007) Br J Haematol , vol.139 , pp. 434-438
    • Oyajobi, B.O.1    Garrett, I.R.2    Gupta, A.3
  • 76
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, Wezeman MJ, Zangari M, et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91:192-9
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3
  • 77
    • 47249093295 scopus 로고    scopus 로고
    • Role of decorin in the antimyeloma effects of osteoblasts
    • Li X, Pennisi A, Yaccoby S. Role of decorin in the antimyeloma effects of osteoblasts. Blood 2008;112:159-68
    • (2008) Blood , vol.112 , pp. 159-168
    • Li, X.1    Pennisi, A.2    Yaccoby, S.3
  • 78
    • 47649120741 scopus 로고    scopus 로고
    • Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
    • Qiang YW, Shaughnessy JD Jr, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood 2008;112:374-82
    • (2008) Blood , vol.112 , pp. 374-382
    • Qiang, Y.W.1    Shaughnessy Jr, J.D.2    Yaccoby, S.3
  • 79
    • 41949093576 scopus 로고    scopus 로고
    • Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo
    • Edwards CM, Edwards JR, Lwin ST, et al. Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo. Blood 2008;111:2833-42
    • (2008) Blood , vol.111 , pp. 2833-2842
    • Edwards, C.M.1    Edwards, J.R.2    Lwin, S.T.3
  • 80
    • 34548133601 scopus 로고    scopus 로고
    • Bortezomib inhibits human osteoclastogenesis
    • von Metzler I, Krebbel H, Hecht M, et al. Bortezomib inhibits human osteoclastogenesis. Leukemia 2007;21:2025-34
    • (2007) Leukemia , vol.21 , pp. 2025-2034
    • von Metzler, I.1    Krebbel, H.2    Hecht, M.3
  • 81
    • 33746336252 scopus 로고    scopus 로고
    • Thalidomide and lenalidomide in the treatment of multiple myeloma
    • Kumar S, Rajkumar SV. Thalidomide and lenalidomide in the treatment of multiple myeloma. Eur J Cancer 2006;42:1612-22
    • (2006) Eur J Cancer , vol.42 , pp. 1612-1622
    • Kumar, S.1    Rajkumar, S.V.2
  • 82
    • 33645736007 scopus 로고    scopus 로고
    • Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1
    • Anderson G, Gries M, Kurihara N, et al. Thalidomide derivative CC-4047 inhibits osteoclast formation by down-regulation of PU.1. Blood 2006;107:3098-105
    • (2006) Blood , vol.107 , pp. 3098-3105
    • Anderson, G.1    Gries, M.2    Kurihara, N.3
  • 83
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008
    • (2008) Leukemia
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 84
    • 0030886244 scopus 로고    scopus 로고
    • Parathyroid hormone (1-34)-mediated interleukin-6 induction
    • Onyia JE, Libermann TA, Bidwell J, et al. Parathyroid hormone (1-34)-mediated interleukin-6 induction. J Cell Biochem 1997;67:265-74
    • (1997) J Cell Biochem , vol.67 , pp. 265-274
    • Onyia, J.E.1    Libermann, T.A.2    Bidwell, J.3
  • 85
    • 38849130851 scopus 로고    scopus 로고
    • Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    • Mukherjee S, Raje N, Schoonmaker JA, et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest 2008;118:491-504
    • (2008) J Clin Invest , vol.118 , pp. 491-504
    • Mukherjee, S.1    Raje, N.2    Schoonmaker, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.