Distinct inflammatory properties of late-activated macrophages in inflammatory myopathies

Acta Myologica

Volumn 27, Issue OCT., 2008, Pages 49-53

  Rostasy, Kevin M ^a   Schmidt, J ^b   Bahn, E ^b   Pfander, T ^b   Piepkorn, M ^b   Wilichowski, E ^b   Schulz Schaeffer, J ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

25F9 positive macrophages; Dermatomyositis; Polymyositis

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; CELL LABELING; CELL MEDIATED CYTOTOXICITY; CELL SUBPOPULATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYOSITIS; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; MUSCLE BIOPSY; PATHOPHYSIOLOGY; POLYMYOSITIS; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ADULT; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CHILD; DERMATOMYOSITIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; MACROPHAGES; NITRIC OXIDE SYNTHASE TYPE II; POLYMYOSITIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 56249113809     PISSN: 11282460     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Dalakas MC, Sivakumar K. The immunopathologic and inflammatory differences between dermatomyositis, polymyositis and sporadic inclusion body myositis. Curr Opin Neurol 1996;9:235-9.
2. Hohlfeld R, Engel AG, Goebels N, Behrens L. Cellular immune mechanisms in inflammatory myopathies. Curr Opin Rheumatol 1997;9:520-6.
3. Schmidt J, Barthel K, Wrede A, et al. Interrelation of inflammation and APP in sIBM: IL-1b induces accumulation of b-amyloid in skeletal muscle. Brain 2008;in press.
4. Bradshaw EM, Orihuela A, McArdel SL, et al. A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol 2007;178:547-56.
5. Greenberg SA. Proposed immunologic models of the inflammatory myopathies and potential therapeutic implications. Neurology 2007;69:2008-19.
6. De Bleecker JL, Meire VI, Declerq W, et al. Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies. Neuromuscul Disord 1999;9:239-46.
7. De Paepe B, Schroeder JM, Martin JJ, et al. Localization of the alpha-chemokine SDF-1 and its receptor CXCR4 in idiopathic inflammatory myopathies. Neuromusc Dis 2004;14:265-73.
8. Frosch M, Vogl T, Seeliger S, et al. Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritis. Arthritis & Rheumatism 2003;48:2622-6.
9. Loetscher, M, Geiser T, O'Reilly T, et al. Cloning of a human even-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. J Biol Chem 1994;269:232-7.
10. Confalonieri P, Bernasconi P, Megna P, et al. Increased expression of beta-chemokines in muscle of patients with inflammatory myopathies. J Neuropathol Exp Neurol 2000;59:164-9.
11. Schulz-Schaeffer WJ, Brueck A, Pueschel K. Macrophage subtyping in the determination of age of injection sites. Int J Legal Med 1996;109:29-33.
12. Zwadlo G, Brueggen J, Gerhards G, et al. Two calcium-binding proteins associated with specific stages of myeloid cell differentiation are expressed by subsets of macrophages in inflammatory tissues. Clin Exp Immunol 1988;72:510-5.
13. Rostasy KM, Piepkorn M, Goebel HH, et al. Monocyte/macrophage differentiation in dermatomyositis and polymyositis. Muscle&Nerve 2004;30:225-30.
14. Mantovani A, Sicca A, Sozzani S, et al. The chemokine system in diverse forms of macrophage activation and polarisation. Trends Immunol 2004;25:677-86.
15. Schmidt J, Rakocevic G, Raju R, et al. Upregulated inducible co-stimulator (ICOS) and ICOS-ligand in inclusion body myositis muscle: significance for CD8+ T cell cytotoxity. Brain 2004;127:1182-90.
16. Arnold L, Henry A, Poron F, et al. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 2007;204:1057-69.
17. Greenberg SA, Pinkus GS, Amato AA, et al. Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve 2007;35:17-23.
18. Greenberg SA, Pinkus JL, Pinkus GS, et al. Interferon-alpha/ beta-mediated innate immune mechanisms in dermatomyositis. Ann Neurol 2005;57:664-78.