Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6451-6453

  Kojima, Naoto ^a   Hayashi, Hiromi ^a   Suzuki, Satoshi ^a   Tominaga, Hiroaki ^a   Maezaki, Naoyoshi ^b   Tanaka, Tetsuaki ^a   Yamori, Takao ^c  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA OHTANI UNIVERSITY   (Japan)

^c CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

Annonaceous acetogenins; Antitumor agents; Fluorinated analogues; Structure activity relationships

Indexed keywords

ACETOGENIN; ANTINEOPLASTIC AGENT; FLUORINE DERIVATIVE; SOLAMIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ACETOGENINS; ANTINEOPLASTIC AGENTS; BENZETHONIUM; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56249092057     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.069     Document Type: Article

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