Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

Journal of Medicinal Chemistry

Volumn 46, Issue 15, 2003, Pages 3185-3188

  Nakanishi, Yuka ^a   Chang, Fang Rong ^b   Liaw, Chih Chuang ^a,b   Wu, Yang Chang ^b   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOGENIN; ANTINEOPLASTIC AGENT; MOLVIZARIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIVISION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY CARCINOMA;

2-PROPANOL; ANNONACEAE; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACIDS; FEMALE; FURANS; HUMANS; OVARIAN NEOPLASMS; PLANT PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037480025     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020548b     Document Type: Article

References (30)

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14. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
15. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
16. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
17. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
18. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
19. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
20. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
21. Annonaceous acetogenins were isolated from Formosan Annonaceous plants in Dr. Yang-Chang Wu's laboratory in Taiwan, including Annona muricata, A. montana, A. atemoya, A. reticulata, and Rollinia mucosa. Compounds 1-18, 22, 23, and 24 were isolated from A. muricata. Compounds 14, 15, 18, 20, and 25 were isolated from A. montana. Compounds 19, 22, 26, 27, and 28 were isolated from A. reticulata. Compounds 19 and 21 were isolated from A. atemoya. Compounds 19 and 27 were isolated from R. mucosa. Among them, 1-7, 9, 10, 20, 23, and 24 were published as new compounds. All of the Annonaceous acetogenins were repurified by reversed-phase HPLC before bioevaluation. (A. muricata I: J. Nat. Prod. 2001, 64, 925-931. A. muricata II: J. Nat. Prod. 2002, 65, 470-475. A. muricata III: Planta Med. 2003, 69, 241-246; A. montana: Heterocycles 1994, 38, 1475-1478; A. reticulata I: Heterocycles 1992, 34, 667-674. A. reticulata II: J. Nat. Prod. 1993, 56, 1688-1694; A. atemoya: Phytochemistry 1999, 51, 883-889; R. mucosa: J. Nat. Prod. 1999, 62, 1613-1617.)
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