Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1α

European Respiratory Journal

Volumn 32, Issue 2, 2008, Pages 443-451

  Riganti, C ^a   Doublier, S ^a   Aldieri, E ^a   Orecchia, S ^b   Betta, P G ^b   Gazzano, E ^a   Ghigo, D ^a,c   Bosia, A ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b C Arrigo Children's Hospital   (Italy)

^c Dipartimento di Genetica Biologia e Biochimica (Sezione di Biochimica)   (Italy)

Author keywords

Asbestos; Doxorubicin resistance; Hypoxia inducible factor 1 ; Iron; Mesothelioma; P glycoprotein

Indexed keywords

ASBESTOS; CROCIDOLITE; DOXORUBICIN; GLYCOPROTEIN P; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON REGULATORY PROTEIN 1; NITRILOTRIACETATE IRON; RAZOXANE; ANTINEOPLASTIC AGENT; IRON;

ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; ANOXIA; DRUG RESISTANCE; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANOXIA; ANTINEOPLASTIC AGENTS; ASBESTOS; ASBESTOS, CROCIDOLITE; CELL LINE, TUMOR; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IRON; LUNG; LUNG NEOPLASMS; MESOTHELIOMA; P-GLYCOPROTEIN; RAZOXANE;

EID: 56149123227     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00090407     Document Type: Article

References (38)

1. Manning CB, Vallyathan V, Mossman BT. Diseases caused by asbestos: mechanisms of injury and disease development. Int Immunopharmacol 2002; 2: 191-200.
2. Tomek S, Emri S, Krejcy K, Manegold C. Chemotherapy for malignant pleural mesothelioma: past results and recent developments. Br J Cancer 2003; 88: 167-174.
3. Lu C, Perez-Soler R, Piperdi B, et al. Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma. J Clin Oncol 2005; 23: 3495-3501.
4. Ogretmen B, Bahadori HR, McMauley MD, Boylan A, Green MR, Safa AR. Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines. Int J Cancer 1998; 75: 757-761.
5. Soini Y, Järvinen K, Kaarteenaho-Wiik R, Kinnula V. The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. Ann Oncol 2001; 12: 1239-1245.
6. Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002; 62: 3387-3394.
7. Brahimi-Horn C, Mazure N, Pouysségur J. Signalling via the hypoxia-inducible factor-1α requires multiple post-translational modifications. Cell Signal 2005; 17: 1-9.
8. Kang GS, Li Q, Chen H, Costa M. Effect of metal ions on HIF-1α and Fe homeostasis in human A549 cells. Mutat Res 2006; 610: 48-55.
9. Haddad JJ, Harb HL. Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α. Int Immunopharmacol 2005; 5: 461-483.
10. O'Donnell JL, Joyce MR, Shannon AM, Harmey J, Geraghty J, Bouchier-Hayes D. Oncological implications of hypoxia inducible factor-1α (HIF-1α) expression. Cancer Treat Rev 2006; 32: 407-416.
11. Quintero M, Mackenzie N, Brennan PA. Hypoxia-inducible factor 1 (HIF-1) in cancer. Eur J Surg Oncol 2004; 30: 465-468.
12. Powis G, Kirkpatrick L. Hypoxia inducible factor-1α as a cancer drug target. Mol Cancer Ther 2004; 3: 647-654.
13. Yu AY, Frid MG, Shimoda LA, Wiener CM, Stenmark K, Semenza GL. Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung. Am J Physiol 1998; 275: L818-L826.
14. Klabatsa A, Sheaff MT, Steele JP, Evans MT, Rudd RM, Fennell DA. Expression and prognostic significance of hypoxia-inducible factor 1α (HIF-1α) in malignant pleural mesothelioma (MPM). Lung Cancer 2006; 51: 53-59.
15. Leard LE, Broaddus VC. Mesothelial cell proliferation and apoptosis. Respirology 2004; 9: 292-299.
16. Fubini B, Barceló F, Otero Areán C. Ferritin adsorption on amosite fibers: possible implications in the formation and toxicity of asbestos bodies. J Toxicol Environ Health 1997; 52: 343-352.
17. Hardy JA, Aust AE. Iron in asbestos chemistry and carcinogenicity. Chem Rev 1995; 95: 97-118.
18. Byrd TF, Horwitz MA. Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens. J Clin Invest 1991; 88: 351-357.
19. Orecchia S, Schillaci F, Salvio M, Libener R, Betta PG. Aberrant E-cadherin and c-catenin expression in malignant mesothelioma and its diagnostic and biological relevance. Lung Cancer 2004; 45: Suppl. 1, S37-S43.
20. Riganti C, Orecchia S, Pescarmona G, Betta PG, Ghigo D, Bosia A. Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma. Int J Cancer 2006; 119: 17-27.
21. Fang Y, Sullivan R, Graham CH. Confluence-dependent resistance to doxorubicin in human MDA-MB-231 breast carcinoma cells requires hypoxia-inducible factor-1 activity. Exp Cell Res 2007; 313: 867-877.
22. Aldieri E, Atragene D, Bergandi L, et al. Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-κB activation. FEBS Lett 2003; 552: 141-144.
23. Riganti C, Miraglia E, Viarisio D, et al. Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux. Cancer Res 2005; 65: 516-525.
24. Buss JL, Hasinoff BB. The one-ring open hydrolysis product intermediates of the cardioprotective agent ICRF-187 (dexrazoxane) displace iron from iron-anthracycline complexes. Agents Actions 1993; 40: 86-95.
25. Constable A, Quick S, Gray NK, Hentze MW. Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function? Proc Natl Acad Sci USA 1992; 89: 4554-4558.
26. Yeo EJ, Chun YS, Cho YS, et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003; 95: 516-525.
27. Biscardi M, Teodori E, Caporale R, et al. Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity. Leuk Res 2006; 30: 1-8.
28. Csiki I, Yanagisawa K, Haruki N, et al. Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1α in non-small cell lung cancer. Cancer Res 2006; 66: 143-150.
29. Zhou J, Damdimopoulos AE, Spyrou G, Brüne B. Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1α. J Biol Chem 2007; 282: 7482-7490.
30. Haddad JJ, Harb HL. L-γ-Glutamyl-L-cysteinyl- glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol 2005; 42: 987-1014.
31. Catalano A, Rodilossi S, Rippo MR, Caprari P, Procopio A. Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. J Biol Chem 2004; 279: 46706-46714.
32. Kamp DW, Weitzman SA. The molecular basis of asbestos induced lung injury. Thorax 1999; 54: 638-652.
33. Aldieri E, Ghigo D, Tomatis M, et al. Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages. Free Radic Biol Med 2001; 31: 412-417.
34. Nymark P, Lindholm PM, Korpela MV, et al. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines. BMC Genomics 2007; 8: 62-75.
35. Riganti C, Aldieri E, Bergandi L, et al. Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells. Free Radic Biol Med 2002; 32: 938-949.
36. Afaq F, Abidi P, Matin R, Rahman Q. Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/particles. Toxicol Lett 1998; 99: 175-182.
37. Tátrai E, Brozik M, Drahos A, et al. The effect of stone-wool on rat lungs and on the primary culture of rat alveolar macrophages and type II pneumocytes. J Appl Toxicol 2006; 26: 16-24.
38. Golladay SA, Park SH, Aust AE. Efflux of reduced glutathione after exposure of human lung epithelial cells to crocidolite asbestos. Environ Health Perspect 1997; 105: Suppl. 5, 1273-1277.