A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997

Journal of Antibiotics

Volumn 61, Issue 6, 2008, Pages 347-355

  Li, Yonghai ^a   He, Weiqing ^a   Wang, Yucheng ^a   Wang, Yiguang ^a   Shao, Rongguang ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Carbamoyltransferase gene; Geldanamycin; Geldanamycin analogues; Gene inactivation; Post polyketide synthase modification

Indexed keywords

4,5 DIHYDRO 19 O GLYCYLGELDANAMYCIN; 4,5 DIHYDRO 7 O DESCARBAMOYL 7 HYDROXY 19 O GLYCYLGELDANAMYCIN; 4,5 DIHYDRO 7 O DESCARBAMOYL 7 HYDROXYGELDANAMYCIN; GELDANAMYCIN; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; 4,5-DIHYDRO-19-O-GLYCYLGELDANAMYCIN; 4,5-DIHYDRO-7-O-DESCARBAMOYL-7-HYDROXY-19-O-GLYCYLGELDANAMYCIN; ANTINEOPLASTIC ANTIBIOTIC; APRAMYCIN; BENZOQUINONE DERIVATIVE; CYTOTOXIN; DRUG DERIVATIVE; MACROCYCLIC LACTAM; NEBRAMYCIN; TRANSFERASE;

AAC3 GENE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SOLUBILITY; ENZYME ACTIVITY; GDMN GENE; GENE INACTIVATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES HYGROSCOPICUS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC ENGINEERING; GENETICS; METABOLISM; MULTIGENE FAMILY; STREPTOMYCES; TUMOR CELL LINE;

STREPTOMYCES; STREPTOMYCES HYGROSCOPICUS;

ANTIBIOTICS, ANTINEOPLASTIC; BENZOQUINONES; CARBOXYL AND CARBAMOYL TRANSFERASES; CELL LINE, TUMOR; CYTOTOXINS; GENE SILENCING; GENETIC ENGINEERING; HUMANS; LACTAMS, MACROCYCLIC; MULTIGENE FAMILY; MUTAGENESIS, INSERTIONAL; NEBRAMYCIN; POLYKETIDE SYNTHASES; STREPTOMYCES;

EID: 56149093392     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.49     Document Type: Article

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